Methods for Inhibiting Sensory Nerves by Topically Administering Strontium-Containing Compositions to Keratinized Skin

Abstract

Topical formulations containing aqueous-soluble divalent strontium cation in a suitable topical keratinized skin formulation vehicle, and methods of using these formulations to inhibit skin irritation in keratinized skin, are disclosed.

1 .- 12 . (canceled) 
     
     
         13 . A method for relieving pain comprising topically applying a compound to keratinized skin comprising a strontium cation, a counterion, and a delivery vehicle. 
     
     
         14 . The method of  claim 13 , wherein the delivery vehicle is selected from the group consisting of: water, organic solvents, lipid-based materials, protein-based materials, silicone-based materials, hydrocarbon-based materials, surfactants, soaps, sustained-release vehicles, stabilizing and suspending agents, emulsifying agents and mixtures of the foregoing. 
     
     
         15 . The method of  claim 13 , wherein the couterion is selected from the group consisting of: fluoride, chloride, bromide, idodine, carbonate, bicarbonate, hydroxide, oxide, peroxide, nitrite, sulfide, bisulfate, persulfate, glycerophosphate, hypophosphate, borate, titanate, carboxylic acid, alkoxylate, citrate, oxalate, acetate, fluconate, lactate, tartrate, maleate, benzoate, propionate, salicylate, ascorbate, formate, succinate, folinate, aspartate, phthalate, oleate, palmitate, stearate, lauryl sulfate, lanolate, myrisatte, behenate, casinate, cyclamate, pantothenate, EDTA, saccharin, thioglycolate, alurate, methylparaben, proylparaben, ricinoleate, and sorbate. 
     
     
         16 . The method of  claim 13 , wherein the compound further comprises a solvent. 
     
     
         17 . The method of  claim 13 , wherein the compound further comprises a skin penetration enhancer.