Guanidino acetic acid used as an animal food additive

Abstract

The present invention relates to the use of guanidinoacetic acid and/or salts thereof as feed additive, in predominantly vegetarian diets, in particular use being made of salts with hydrochloric acid, hydrobromic acid and phosphoric acid. The use proceeds especially in individual doses from 0.01 to 100 g/kg of feed in the form of powders, granules, pastilles or capsules, the feed additive also being able to be used in combination with other physiologically active materials of value. The claimed use which is suitable especially for breeding and growing livestock, has recourse to a compound which is in particular stable in aqueous solution, can be converted to creatine under physiological conditions, and, in contrast to other guanidine derivatives, is completely available to physiological sectors of use.

1 - 9 . (canceled) 
     
     
         10 . A method comprising improving feed uptake, increasing growth performance, increasing muscle meat gain, increasing meat quality or increasing reproduction performance in an animal by administering a sufficient amount of feed additive as a part of a diet for the animal, wherein the feed additive comprises guanidinoacetic, acid or a salt thereof, wherein the feed additive is administered to animals in an aquaculture. 
     
     
         11 . A method comprising administering a therapeutic composition comprising guanidinoacetic acid or a salt thereof for breeding and growing an animal to strengthen the immune system and to improve the reproduction performance of the animal, wherein the therapeutic composition is administered to animals in an aquaculture. 
     
     
         12 . A method comprising administering a sufficient amount of a composition comprising guanidinoacetic acid or a salt thereof to breeding and growing animals to prevent or mitigate a consequence of heat stress, wherein the composition is administered to animals in an aquaculture. 
     
     
         13 . The method of  claim 10 , wherein the animal is a salmon or a shrimp. 
     
     
         14 . The method of  claim 11 , wherein the animal is a salmon or a shrimp. 
     
     
         15 . The method of  claim 12 , wherein the animal is a salmon or a shrimp. 
     
     
         16 . The method of  claim 10 , wherein the feed additive comprising guanidinoacetic acid or a salt thereof is administered as a part of a predominantly vegetarian diet. 
     
     
         17 . The method of  claim 10 , wherein the feed additive comprising guanidinoacetic acid or a salt thereof is administered as partial or total replacement of fish meal or of a antimicrobial performance enhancer. 
     
     
         18 . The method of  claim 11 , wherein the therapeutic composition comprising guanidinoacetic acid or a salt thereof is administered as a part of a predominantly vegetarian diet. 
     
     
         19 . The method of  claim 11 , wherein the therapeutic composition comprising guanidinoacetic acid or a salt thereof is administered as partial or total replacement for fish meal, meat meal, an anabolic agent, an antimicrobial performance enhancer or a growth hormone. 
     
     
         20 . The method of  claim 12 , wherein mortality as a consequence of elevated ambient temperatures is reduced. 
     
     
         21 . The method of  claim 10 , wherein the salt is a hydrochloric acid, hydrobromic acid or phosphoric acid salt. 
     
     
         22 . The method of  claim 21 , wherein the salt is a hydrochloric acid. 
     
     
         23 . The method of  claim 11 , wherein the salt is a hydrochloric acid, hydrobromic acid or phosphoric acid salt. 
     
     
         24 . The method of  claim 10 , wherein the guanidinoacetic acid or salt thereof is provided as an individual dose of from 0.01 to 100 g/kg of the composition. 
     
     
         25 . The method of  claim 24 , wherein the dose is 1.0 to 5.0 g/kg of the composition. 
     
     
         26 . The method of  claim 11 , wherein the guanidinoacetic acid or salt thereof is provided as an individual dose of from 0.01 to 100 g/kg of the composition. 
     
     
         27 . The method of  claim 26 , wherein the dose is 1.0 to 5.0 g/kg of the composition. 
     
     
         28 . The method of  claim 12 , wherein the guanidinoacetic acid or salt thereof is provided as an individual dose of from 0.01 to 100 g/kg of the composition. 
     
     
         29 . The method of  claim 28 , wherein the dose is 1.0 to 5.0 g/kg of the composition. 
     
     
         30 . The method of  claim 10 , wherein the composition is in the form of a powder, a granule, a pastille, a capsule, a pellet, a conglomerate or a gel product. 
     
     
         31 . The method of  claim 11 , wherein the composition is in the form of a powder, a granule, a pastille, a capsule, a pellet, a conglomerate or a gel product. 
     
     
         32 . The method of  claim 12 , wherein the composition is in the form of a powder, a granule, a pastille, a capsule, a pellet, a conglomerate or a gel product. 
     
     
         33 . The method of  claim 10 , wherein the composition further comprises a carbohydrate, a fat, an amino acid, a protein, a vitamin, a mineral or a trace element, or a physiologically active methyl group donor. 
     
     
         34 . The method of  claim 11 , wherein the composition further comprises a carbohydrate, a fat, an amino acid, a protein, a vitamin, a mineral or a trace element, or a physiologically active methyl group donor, 
     
     
         35 . The method of  claim 12 , wherein the composition further comprises a carbohydrate, a fat, an amino acid, a protein, a vitamin, a mineral or a trace element, or a physiologically active methyl group donor. 
     
     
         36 . A method comprising preparing a wet or dry feed for a dog or a cat by adding to the wet or dry feed a guanidinoacetic acid or a salt thereof with at least one wet or dry feed component for cat or dog feed, 
     
     
         37 . A method comprising positively effecting the immune system or the general status of dogs or cats, by administering a sufficient amount of a feed additive as part of cat or dog feeds to dogs or cats, wherein the feed additive comprises guanidinoacetic acid or a salt thereof. 
     
     
         38 . A feed additive comprising guanidinoacetic acid or a salt thereof. 
     
     
         39 . The feed additive of  claim 38  for salmon or shrimp. 
     
     
         40 . The feed additive of  claim 38  for dogs or cats.