Formulations and methods for treating amyloidosis

Abstract

Methods, formulations, and compositions for the treatment of amyloidosis are described.

1 . (canceled) 
     
     
         2 . A method of stabilizing or improving renal and/or gastrointestinal function in a subject in need thereof, said method comprising:
 administering to said subject a therapeutically effective amount of a compound selected from the group consisting of:   1,2-ethanedisulfonic acid,   sodium 1,2-ethanedisulfonate,   1.2-ethanediol bis(hydrogen sulfate),   1,2-ethanediol disulfate, disodium salt,   1,3-propanedisulfonic acid,   sodium 1,3-propanedisulfonate (1,3-propanedisulfonic acid, disodium salt),   1,3-propanediol bis(hydrogen sulfate),   1,3-propanediol disulfate, disodium salt,   2-sulfomethyl-1,4-butanedisulfonic acid, and   2-sulfomethylbutane-1,4-disulfonic acid, trisodium salt.   
     
     
         3 . The method of  claim 2  wherein said compound is 1,2-ethanedisulfonic acid. 
     
     
         4 . The method of  claim 2  wherein said compound is sodium 1,2-ethanedisulfonate. 
     
     
         5 . The method of  claim 2  wherein said compound is 1,2-ethanediol bis(hydrogen sulfate). 
     
     
         6 . The method of  claim 2  wherein said compound is 1,2-ethanediol disulfate, disodium salt. 
     
     
         7 . The method of  claim 2  wherein said compound is 1,3-propanedisulfonic acid. 
     
     
         8 . The method of  claim 2  wherein said compound is sodium 1,3-propanedisulfonate (1,3-propanedisulfonic acid, disodium salt). 
     
     
         9 . The method of  claim 2  wherein said compound is 1,3-propanediol bis(hydrogen sulfate). 
     
     
         10 . The method of  claim 2  wherein said compound is 1,3-propanediol disulfate, disodium salt. 
     
     
         11 . The method of  claim 2  wherein said compound is 2-sulfomethyl-1,4-butanedisulfonic acid. 
     
     
         12 . The method of  claim 2  wherein said compound is 2-sulfomethylbutane-1,4-disulfonic acid, trisodium salt. 
     
     
         13 . A method of treating a malignant neoplasm in a subject in need thereof, said method comprising:
 administering to said subject a therapeutically effective amount of a compound selected from the group consisting of:   1,2-ethanedisulfonic acid,   sodium 1,2-ethanedisulfonate,   1,2-ethanediol bis(hydrogen sulfate),   1,2-ethanediol disulfate, disodium salt,   1,3-propanedisulfonic acid,   sodium 1,3-propanedisulfonate (1,3-propanedisulfonic acid, disodium salt),   1,3-propanediol bis(hydrogen sulfate),   1,3-propanediol disulfate, disodium salt,   2-sulfomethyl-1,4-butanedisulfonic acid, and   2-sulfomethylbutane-1,4-disulfonic acid, trisodium salt,   
       in combination with a second agent such that the malignant neoplasm is treated in said subject. 
     
     
         14 . A method of treating a chronic infection in a subject in need thereof, said method comprising:
 administering to said subject a therapeutically effective amount of a compound selected from the group consisting of:   1,2-ethanedisulfonic acid,   sodium 1,2-ethanedisulfonate,   1,2-ethanediol bis(hydrogen sulfate),   1,2-ethanediol disulfate, disodium salt,   1,3-propanedisulfonic acid,   sodium 1,3-propanedisulfonate (1,3-propanedisulfonic acid, disodium salt),   1,3-propanediol bis(hydrogen sulfate),   1,3-propanediol disulfate, disodium salt,   2-sulfomethyl-1,4-butanedisulfonic acid, and   2-sulfomethylbutane-1,4-disulfonic acid, trisodium salt,   
       in combination with a second agent such that the chronic infection is treated in said subject.