Non-sedating antihistamine injection formulations and methods of use thereof

Abstract

Described herein are injectable compositions containing non-sedating or second and third generation antihistamines such as cetirizine/levocetirizine and methods of use thereof. Specifically, methods of treating acute urticaria or angioedema associated with an acute allergic reaction are disclosed. In certain embodiments, the injectable compositions are bioequivalent to currently marketed oral dosage forms with the same number of mg of cetirizine.

1 . A method of treating a patient in need of injection with cetirizine, comprising, comprising
 administering to the patient an intramuscular injection of an injectable cetirizine composition containing 2 mg to 20 mg of cetirizine,   wherein at least about 5 ng/mL of cetirizine appears in the patient's bloodstream within about 4 minutes of administration.   
     
     
         2 . The method of  claim 1 , wherein the patient is in need of treatment for acute urticaria or angioedema associated with an acute allergic reaction, wherein the acute allergic reaction optionally includes anaphylaxis. 
     
     
         3 . The method of  claim 1 , wherein it is not feasible to administer oral cetirizine to the patient.