Sunscreen Compositions Comprising Uniform, Rigid, Spherical, Nanoporous Calcium Phosphate Particles and Methods of Making and Using the Same

Abstract

Aspects of the invention include sunscreen formulations that include uniform, rigid, spherical nanoporous calcium phosphate particles. Also provided are methods of making the sunscreen formulations. The sunscreen formulations find use in sunblocking applications.

What is claimed is: 
     
         1 . A sunscreen composition comprising:
 uniform, rigid, spherical, nanoporous calcium phosphate particles; and   a sunscreen delivery vehicle.   
     
     
         2 . The sunscreen composition according to  claim 1 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle is ceramic. 
     
     
         3 . The sunscreen composition according to  claim 1 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle has a diameter ranging from 0.05 to 50 μm. 
     
     
         4 . The sunscreen composition according to  claim 1 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle have a surface area ranging from 10 m 2 /g to 150 m 2 /g. 
     
     
         5 . The sunscreen composition according to  claim 1 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle comprises pores are sintered. 
     
     
         6 . The sunscreen composition according to  claim 1 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle comprises pores are loaded with anti-oxidants. 
     
     
         7 . The sunscreen composition according to  claim 1 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle comprises pores are loaded with additional sunscreens. 
     
     
         8 . The sunscreen composition according to  claim 1 , wherein the sunscreen delivery vehicle is an oil-in-water or water-in-oil emulsion. 
     
     
         9 . The sunscreen composition according to  claim 1 , wherein the sunscreen delivery vehicle comprises inorganic UV shielding particles; organic UV absorbers; a polymeric water-proof component and a lipophilic component. 
     
     
         10 . A sunscreen composition comprising by weight:
 (a) from 0.001% to 10% of uniform rigid spherical nanoporous calcium phosphate particles;   (b) from about 0.1% to about 50% of inorganic UV shielding particles;   (c) from about 0.1% to about 15% of organic UV absorbers;   (d) from about 0.1% to about 10% of a polymeric water-proof component;   (e) 30% or more lipophilic component; and   (f) water.   
     
     
         11 . The sunscreen composition according to  claim 10 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle is ceramic. 
     
     
         12 . The sunscreen composition according to  claim 10 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle has a diameter ranging from 0.05 to 50 μm. 
     
     
         13 . The sunscreen composition according to  claim 10 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle have a surface area ranging from 10 m 2 /g to 150 m 2 /g. 
     
     
         14 . The sunscreen composition according to  claim 10 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle comprises pores are sintered. 
     
     
         15 . The sunscreen composition according to  claim 10 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle comprises pores are loaded with anti-oxidants. 
     
     
         16 . The sunscreen composition according to  claim 10 , wherein the uniform, rigid, spherical, nanoporous calcium phosphate particle comprises pores are loaded with organic or inorganic UV absorbers and/or blockers. 
     
     
         17 . A method comprising:
 applying a sunscreen composition comprising:
 (a) uniform, rigid, spherical, nanoporous calcium phosphate particles; and 
 (b) a sunscreen delivery vehicle; 
   to a topical region of a subject.   
     
     
         18 . The method according to  claim 17 , wherein the topical region is a keratinized skin surface.