Method of Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides

Abstract

The use of flagellin and flagellin related polypeptides for reducing cancer treatment side effects in mammals is described.

1 .- 7 . (canceled) 
     
     
         8 . A method of reducing a side effect of cancer treatment in a mammal in need thereof, comprising administering a therapeutically effective amount of a composition comprising flagellin, wherein the cancer therapy comprises radiation therapy and cisplatinum. 
     
     
         9 . The method of  claim 8 , wherein the mammal is a human. 
     
     
         10 . The method of  claim 8 , wherein the cisplatinum is administered at 50-270 mg/m 2 /day. 
     
     
         11 . The method of  claim 8 , wherein the side effect is one or more of myelosuppression, renal toxicity, weight loss pain, nausea, vomiting, diarrhea, constipation, anemia, malnutrition, hair loss, numbness, changes in tastes, loss of appetite, thinned or brittle hair, mouth sores, memory loss, hemorrhage, cardiotoxicity, hepatotoxicity, ototoxicity, and post-chemotherapy cognitive impairment. 
     
     
         12 . The method of  claim 11 , wherein the behavioral change is limited mobility. 
     
     
         13 . The method of  claim 11 , wherein the side effect is selected from the group consisting of: myelosuppression, renal toxicity, and weight loss. 
     
     
         14 . The method  claim 11 , wherein the mammal is a human. 
     
     
         15 . The method of  claim 11 , wherein the cisplatinum is administered at 50-270 mg/m 2 /day.