Learning motivation improvers

Abstract

The present invention aims to provide antidepressants which are free from the problem of side effects and are excellent in safety. The present invention also aims to provide learning motivation improvers which are useful for improvement of learning motivation and can be ingested continuously. The present invention provides antidepressants and learning motivation improvers, each comprising a cyclic dipeptide with the 2,5-diketopiperazine structure as an active ingredient.

What is claimed is: 
     
         1 . A method of treating depression comprising administering an effective amount of 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S) to a subject in recognized need thereof. 
     
     
         2 . The method according to  claim 1 , wherein the administration is oral administration. 
     
     
         3 . The method according to  claim 1 , wherein the 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S) is present in a food, beverage, tablet, capsule, powder, granule, solution, or elixir. 
     
     
         4 . The method according to  claim 1 , wherein the 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S) is administered as a prophylactic and/or therapeutic agent for treatment of depression, senile depression symptoms, depressed mood, hypobulia, anxiety, or insomnia or anorexia associated with these symptoms. 
     
     
         5 . A method of treating depression comprising administering an antidepressant comprising an effective amount of one or more members selected from the group consisting of 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S); pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(1H-imidazol-4-ylmethyl)-,(3 S,8aS); pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(1H-indo1-3-ylmethyl)-,(3S,8aS); 2,5-piperazinedione,3,6-bis(1 H-indo1-3-ylmethyl)-,(3S,6S); pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(2-methylpropyl)-,(3S,8aS); and pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(1-methylethyl)-,(3S,8aS), to a subject in recognized need thereof. 
     
     
         6 . The method according to  claim 5 , wherein the administration is oral administration. 
     
     
         7 . The method according to  claim 5 , wherein the antidepressent is present in a food, beverage, tablet, capsule, powder, granule, solution, or elixir. 
     
     
         8 . The method according to  claim 5 , wherein the antidepressant is administered as a prophylactic and/or therapeutic agent for treatment of depression, senile depression symptoms, depressed mood, hypobulia, anxiety, or insomnia or anorexia associated with these symptoms. 
     
     
         9 . A method for improving learning motivation comprising administering an effective amount of 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S) to a subject in recognized need thereof. 
     
     
         10 . The method according to  claim 9 , wherein the administration is oral administration. 
     
     
         11 . The method according to  claim 9 , wherein the 2,5-piperazinedione,3,6-bis(phenylmethyl)-,(3S,6S) is present in a food, beverage, tablet, capsule, powder, granule, solution, or elixir.