Analgesic medication

Abstract

An analgesic medication includes an oligonucleotide being a double strand RNA comprising 18 to 70 base pairs, and a pharmaceutical acceptable vehicle for delivering the said oligonucleotide into cells, wherein a dosage of the oligonucleotide in the analgesic is 50 μg to 200 μg/kg per time, and the pharmaceutical acceptable vehicle is selected from a group of polyethyleneimine, lipofectamine and iFect.

1 . An analgesic medication comprising:
 an oligonucleotide being a double strand RNA comprising 18 to 70 base pairs with the oligonucleotide being not homologous to any organism genes; and   a pharmaceutical acceptable vehicle, for delivering the said oligonucleotide into cells;   wherein a dosage of the oligonucleotide in the analgesic medication is 50 μg to 200 μg/ per kg/per time.   
     
     
         2 . (canceled) 
     
     
         3 . The analgesic medication as defined in  claim 1 , wherein the oligonucleotide comprises sequences set forth in SEQ ID NO: 1 and 2. 
     
     
         4 . (canceled) 
     
     
         5 . The analgesic medication as defined in  claim 1 , wherein the oligonucleotide and the pharmaceutical acceptable vehicle are mixed in a ratio of 1 μg: 0.18 μl. 
     
     
         6 . The analgesic medication as defined in  claim 1 , wherein the oligonucleotide is chemically synthesized oligonucleotide. 
     
     
         7 . The analgesic medication as defined in  claim 1 , wherein the oligonucleotide is vector-expressed oligonucleotide. 
     
     
         8 . A method of analgesia comprising, wherein administrating the analgesic medication as claimed in  claim 1  to an individual via intrathecal injection. 
     
     
         9 . The method of analgesia as defined in  claim 8 , wherein the individual is human body or rat. 
     
     
         10 . The analgesic medication as defined in  claim 1 , with the oligonucleotide being small interfering RNA, short hairpin RNA, or microRNA, 
     
     
         11 . The method of analgesia as defined in  claim 8 , wherein the analgesic medication is used for systemic analgesia or pain relief. 
     
     
         12 . The method of analgesia defined in  claim 11 , wherein the analgesic medication is used for local analgesia on lumbar vertebra, extremity or lower body. 
     
     
         13 . The analgesic medication as defined in  claim 1 , wherein the pharmaceutical acceptable vehicle is selected from a group of polyethyleneimine, lipofectamine and iFect.