4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs

Abstract

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

1 - 95 . (canceled) 
     
     
         96 . A pharmaceutical composition comprising a compound which is 
       
         
           
           
               
               
           
         
         (R)-{4-[2-Ethoxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid 
         or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. 
       
     
     
         97 . The pharmaceutical composition of  claim 96  wherein the pharmaceutical composition is a tablet or a capsule. 
     
     
         98 . A method of treating a condition selected from the group consisting of diabetes, cardiovascular diseases, Metabolic X Syndrome, hypercholesterolemia, hypo-HDL-cholesterolemia, hyper-LDL-cholesterolemia, dyslipidemia, atherosclerosis, and obesity, comprising administering to a patient in need of treatment a pharmaceutical composition of  claim 96 . 
     
     
         99 . A pharmaceutical composition comprising a compound which is 
       
         
           
           
               
               
           
         
         (S)-{4-[2-Ethoxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid 
         or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. 
       
     
     
         100 . The pharmaceutical composition of  claim 99  wherein the pharmaceutical composition is a tablet or a capsule. 
     
     
         101 . A method of treating a condition selected from the group consisting of diabetes, cardiovascular diseases, Metabolic X Syndrome, hypercholesterolemia, hypo-HDL-cholesterolemia, hyper-LDL-cholesterolemia, dyslipidemia, atherosclerosis, and obesity, comprising administering to a patient in need of treatment a pharmaceutical composition of  claim 99 . 
     
     
         102 . A pharmaceutical composition comprising a compound which is 
       
         
           
           
               
               
           
         
         {4-[2-Ethoxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid 
         or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. 
       
     
     
         103 . The pharmaceutical composition of  claim 102  wherein the pharmaceutical composition is a tablet or a capsule. 
     
     
         104 . A method of treating a condition selected from the group consisting of diabetes, cardiovascular diseases, Metabolic X Syndrome, hypercholesterolemia, hypo-HDL-cholesterolemia, hyper-LDL-cholesterolemia, dyslipidemia, atherosclerosis, and obesity, comprising administering to a patient in need of treatment a pharmaceutical composition of  claim 102 .