Human toll homologues

Abstract

The invention relates to the identification and isolation of novel DNAs encoding the human Toll proteins PRO285, PRO286, and PRO358, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO285, or PRO286, or PRO358 Toll protein.

1 .- 40 . (canceled) 
     
     
         41 . An isolated antibody which binds to a PRO358 polypeptide consisting essentially of amino acids 1 to 811 encoded by SEQ ID NO:14. 
     
     
         42 . The antibody of  claim 41  wherein said antibody is a monoclonal antibody. 
     
     
         43 . The antibody of  claim 42  wherein said antibody is one of a chimeric, humanized, and human antibody. 
     
     
         44 . The antibody of  claim 42  wherein said antibody blocks binding of said polypeptide to one of a Gram-negative and Gram-positive organism. 
     
     
         45 . An isolated antibody which specifically binds to a-PRO358 polypeptide consisting essentially of amino acid residues 20 to 575 of  FIG. 3  (SEQ ID NO: 13). 
     
     
         46 . The antibody of  claim 45  wherein said antibody is a monoclonal antibody. 
     
     
         47 . The antibody of  claim 46  wherein said antibody is one of a chimeric, humanized, and human antibody. 
     
     
         48 . An isolated antibody which binds to a PRO358 polypeptide consisting essentially of:
 (a) amino acids 1 to 811 encoded by SEQ ID NO: 14, or   (b) amino acid residues 20 to 575 of SEQ ID NO: 13;   wherein said antibody is an agonist or an antagonist of NF-KB activation.   
     
     
         49 . The antibody of  claim 48 , wherein said antibody is an agonist of NF-KB activation. 
     
     
         50 . The antibody of  claim 48 , wherein said antibody is an antagonist of NF-KB activation. 
     
     
         51 . An isolated antibody which specifically binds to a-PRO358 polypeptide consisting essentially of amino acid residues 1 to 811 of  FIG. 3  (SEQ ID NO: 13).