US2013338343A1PendingUtilityA1

Compositions and methods for treating kidney disease

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Assignee: STOWERS INST FOR MEDICAL RESPriority: Jun 14, 2002Filed: Jul 25, 2013Published: Dec 19, 2013
Est. expiryJun 14, 2022(expired)· nominal 20-yr term from priority
Inventors:Robb KrumlaufDebra Ellies
C07K 14/575C07K 16/30C07K 2317/626A01K 2217/075A61K 48/00A61P 13/12A61K 38/00C07K 14/47A01K 2227/105C07K 2317/34C07K 2317/55C07K 2317/76A01K 2217/05C07K 2317/54C07K 14/4702A61K 2039/505C07K 14/705C07K 16/18C07K 2317/622
66
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Claims

Abstract

The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to subjects in order to prevent or treat renal degeneration or damage.

Claims

exact text as granted — not AI-modified
1 - 20 . (canceled) 
     
     
         21 . An isolated antibody that specifically binds to 5, 8, 10, or 15 contiguous amino acids of SEQ ID NO: 171. 
     
     
         22 . The isolated antibody of  claim 21 , wherein the antibody specifically binds to 5 contiguous amino acids of SEQ ID NO: 171. 
     
     
         23 . The isolated antibody of  claim 21 , wherein the antibody specifically binds to 8 contiguous amino acids of SEQ ID NO: 171. 
     
     
         24 . The isolated antibody of  claim 21 , wherein the antibody specifically binds to 10 contiguous amino acids of SEQ ID NO: 171. 
     
     
         25 . The isolated antibody of  claim 21 , wherein the antibody specifically binds to 15 contiguous amino acids of SEQ ID NO: 171. 
     
     
         26 . The isolated antibody of  claim 22 , wherein the antibody is selected from the group consisting of a monoclonal antibody, a polyclonal antibody, a Fv fragment of an antibody, a Fab fragment of an antibody, a F(ab′) 2  fragment of an antibody, a recombinant single chain Fv fragment (scFv), a diabody, a triabody, and a tetrabody. 
     
     
         27 . The isolated antibody of  claim 26 , wherein the antibody is a monoclonal antibody.

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