US2013345396A1PendingUtilityA1

Angiotensin converting enzyme inhibitory peptide

Assignee: NAKAHARA TAKEHARUPriority: Jan 19, 2009Filed: Aug 30, 2013Published: Dec 26, 2013

Est. expiryJan 19, 2029(~2.5 yrs left)· nominal 20-yr term from priority

Inventors:Takeharu Nakahara Riichiro Uchida Hitomi Aota Katsutoshi Sugimoto Takuya Sato

A61P 43/00A61P 9/12C07K 5/06078C07K 5/0806C07K 5/0819C07K 5/0808A61K 38/06C07K 5/06173A61K 38/00C07K 5/06113C07K 5/04C07K 2/00C07K 5/06165C07K 5/06C07K 5/00

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Claims

Abstract

To provide ACE inhibitory peptides which can effectively inhibit ACE by a small amount of ingestion and have no fear of causing side effects and which can be orally ingested easily during daily life by persons having high blood pressure, and compositions comprising the peptides. The peptides represented by the following structural formulae (1) to (9), and salts thereof are provided. (1) Asp-Arg-Pro, (2) Asn-Trp, (3) Val-Gly-Leu, (4) Ile-Gly-Val, (5) Gly-Val-Pro, (6) Ile-Pro-Tyr, (7) pyroGlu-Pro, (8) Tyr-Thr, (9) Pro-Trp

Claims

exact text as granted — not AI-modified

1 . An angiotensin converting enzyme inhibitory peptide represented by the following structural formula: pyroGlu-Pro and salts thereof. 
     
     
         2 . An angiotensin converting enzyme inhibitor, which comprises the peptide described in  claim 1 . 
     
     
         3 . A composition which comprises the peptide described in  claim 1  and alleviates symptoms of high blood pressure. 
     
     
         4 . A method for producing the peptide described in  claim 1 , wherein soybean is mixed and stirred at 25° C. or more with a koji fungus culture.

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