Immunogenic Influenza Composition

Abstract

Methods for providing novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host. The novel immunogens can be used as vaccines or to develop antibodies.

The disclosure is claimed as follows: 
     
         1 . An isolated composition comprising an immunogenic epitope of influenza that is not immunodominant as in a wild type virus. 
     
     
         2 . The composition of  claim 1  comprising a hemagglutinin. 
     
     
         3 . The composition of  claim 1  comprising a neuraminidase. 
     
     
         4 . The composition of  claim 1  comprising an influenza virus particle. 
     
     
         5 . The composition of  claim 4 , wherein said particle is inactivated, attenuate or non-infectious. 
     
     
         6 . The composition of  claim 1  wherein said composition comprises addition or removal of a glycosylation site. 
     
     
         7 . The composition of  claim 1 , wherein said composition comprises an amino acid addition, substitution or deletion. 
     
     
         8 . The composition of  claim 1  comprising a virus-like particle. 
     
     
         9 . The composition of  claim 1  expressed on the surface of influenza virus. 
     
     
         10 . The composition of  claim 1 , further comprising a pharmaceutically acceptable carrier, diluent or excipient. 
     
     
         11 . The composition of  claim 1 , wherein said influenza is human influenza, avian influenza, swine influenza, canine influenza or horse influenza.