1h-imidazo[4,5-c]quinolinone derivatives

Abstract

The invention relates to the use of 1H-imidazo[4,5-c]quinolinone derivatives and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c]quinolinone derivatives for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1H-imidazo[4,5-c]quinolinone derivatives to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1H-imidazo[4,5-c]quinolinone derivative, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1H-imidazo[4,5-c]quinolinone derivatives; and a process for the preparation of the novel 1H-imidazo[4,5-c]quinolinone derivatives.

What is claimed is: 
     
         1 . A compound of formula (I): 
       
         
           
           
               
               
           
         
         in which: 
         R 1  is a group selected from: 
       
       
         
           
           
               
               
           
         
         
           wherein, the curved line indicates the bonding position to the rest of the molecule of formula (I) and the alpha position is shown by the atoms labeled with a * symbol, and 
           R 10  is C 1 -C 4 alkyl; 
           R 11  is hydrogen or C 1 -C 4 alkyl or fluoroC 1 -C 4 alkyl; 
           R 12  is hydrogen or C 1 -C 4 alkyl; 
           R 13  is hydrogen or C 1 -C 4 alkyl; 
           R 14  is C 1 -C 4 alkyl, 2-hydroxyethyl, methoxyethyl, hydroxycarbonylmethyl (HOC(O)CH 2 —), dimethylaminocarbonylmethyl (Me 2 NC(O)CH 2 —), ethylmethylaminocarbonylmethyl (EtMeNC(O)CH 2 —), (methoxyethyl)(methyl)aminocarbonylmethylmethyl ((MeOEt)(Me)NC(O)CH 2 —), 2-azetidin-1-yl-2-oxo-ethyl, 4-morpholinecarbonylmethyl and (4-methylpiperazin-1yl)carbonylmethyl; and 
           R 15  is methyl or chloro, 
         
         or R 1  is a group of formula (AB): 
       
       
         
           
           
               
               
           
         
         wherein, the curved line indicates the bonding position to the rest of the molecule of formula (I) and the alpha position is shown by the atoms labeled with a * symbol, and 
         R 16  and R 17  are independently selected from same or different, unsubstituted C 1 -C 4 alkyl; 
         R 2  is hydrogen, C 1 -C 4 alkyl or C 1 -C 4 alkenyl; 
         R 3  is unsubstituted phenyl, or phenyl substituted with one or two groups independently selected from the group consisting of halo; halo-lower alkyl; hydroxyl; amino; mono or disubstituted amino; cyclic amino; amino-lower alkyl; lower alkoxy; hydroxy-lower alkyl; hydroxy lower alkoxy; lower alkyl; cyano; cyano-lower alkyl; amidino; N-hydroxyamidino; amidino-lower alkyl; or N-hydroxyamidino-lower alkyl; sulfonyl; alkyl-substituted sulfonyl; sulfonamide; pyrrolidinesulfonyl; lower alkyl sulfonyl amino; lower alkyl sulfonylalkandiylamino; lower alkylsulfonyl-N-lower alkylamino; [1,3]dioxolo; halo-substituted [1,3]dioxolo; alkoxy carbonyl; carbamoyl; substituted carbamoyl; heterocycle; heterocyclyl lower alkyl; heteroaryl or heteroaryl lower alkyl; or 
         R 3  is indolyl, 1-methyl-2,3-dihydro-1H-indolyl, 2-oxo-2,3-dihydro-1H-indolyl, pyridyl, pyrimidinyl, 1H-pyrrolo[2,3-b]pyridinyl, 1-methyl-1H-pyrrolo[2,3-b]pyridinyl, pyrazolyl, pyrazinyl, quinolyl, 1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridinyl, 1-ethyl-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridinyl, 1-(2-methoxy-ethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridinyl, 2-Dimethylamino-3-methyl-3H-imidazo[4,5-b]pyridinyl, 2-methoxy-3-methyl-3H-imidazo[4,5-b]pyridinyl, 3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridinyl, 2,3-Dimethyl-3H-imidazo[4,5-b]pyridinyl, 3-methyl-3H-imidazo[4,5-b]pyridinyl, 1H-pyrrolo[3,2-b]pyridinyl, 1-methyl-1H-pyrrolo[3,2-b]pyridinyl, 1-methyl-2-oxo-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazinyl, 4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, 1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridinyl and 1-ethyl-2-oxo-1,4-dihydro-2H-pyrido[3,2-d][1,3]oxazinyl each of these heterocycle radicals being unsubstituted or substituted by one to two radicals selected from the group consisting of halo; halo-lower alkyl; hydroxyl; amino; mono or disubstituted amino; cyclic amino; substituted cyclic amino; amino-lower alkyl; alkylamino-lower alkyl; dialkylamino-loweralkyl; cycloalkylaminoalkyl; dicycloalkylaminoalkyl; alkylcycloalkylaminoalkyl; lower alkoxy; cycloalkoxy; lower-alkoxyalkyl; hydroxy-lower alkyl; hydroxy lower cycloalkyl; hydroxy lower alkoxy; alkoxy lower alkoxy; lower alkyl; cyano; cyano-lower alkyl; cyano lower cycloalkyl; amidino; N-hydroxyamidino; amidino-lower alkyl; N-hydroxyamidino-lower alkyl; nitro; carboxylic acid; substituted sulfonyl; sulfonamide; alkylsulfonylamino; alkylsulfonylalkylamino; acylamino; acyl alkyl amino; alkylcarbonylaminoalkyl; alkylaminocarbonylalkyl; alkylcarbonyl-N-alkylamino; [1,3]dioxolo; substituted [1,3]dioxolo; alkoxy carbonyl; carbamoyl; substituted carbamoyl; 1H-tetrazolyl; pyrazol; imidazole; triazole; azetidinyl; pyrrolidinyl; piperazinyl; methylpiperazinyl; ethylpiperazinyl; triazolonyl; methylimidazolyl or morpholino; 
         R 4 , R 5  and R 6  are hydrogen; 
         X is O or S; and 
         Y is CH or N; or a pharmaceutically acceptable salt thereof. 
       
     
     
         2 . The compound of  claim 1  wherein R 1  is selected from: 1,5-dimethyl-1H-pyrazol-4-yl, 2-ethyl-2H-pyrazol-3-yl, 2-methyl-2H-pyrazol-3-yl, 2,5-dimethyl-2H-pyrazol-3-yl, 1-isopropyl-3-methyl-1H-pyrazol-4-yl, 1-ethyl-3-methyl-1H-pyrazol-4-yl, 2,4-dimethyl-2H-pyrazol-3-yl, 1,3-dimethyl-1H-pyrazol-4-yl, 1,3,5-trimethyl-1H-pyrazol-4-yl, 2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl, 1-hydroxycarbonyl methyl-3-methyl-pyrazol-4-yl, 1-dimethylaminocarbonylmethyl-3-methyl-pyrazol-4-yl, 1-dimethylaminocarbonylmethyl-3,5-dimethyl-pyrazol-4-yl, 1-diethylaminocarbonylmethyl-3-methyl-pyrazol-4-yl, 1-(2-hydroxyethyl)-3-methyl-pyrazol-4-yl, 1-(2-azetidin-1-yl-2-oxo-ethyl)-3-methyl-1H-pyrazol-4-yl, 1-(4-morpholin)-carbonylmethyl-3-methyl-pyrazol-4-yl, 3-methyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-pyrazol-4-yl, 1-methyl-3-chloro-pyrazol-4-yl, 1-(2-methoxyethyl)-3,5-dimethyl-pyrazol-4-yl and 1-N-ethyl-N-methylaminocarbonylmethyl-3-methyl-pyrazol-4-yl and 3,5-dimethyl-isoxazol-4-yl, or a pharmaceutically acceptable salt thereof. 
     
     
         3 . The compound of  claim 1  wherein R 3  is selected from: phenyl; hydroxyphenyl; methoxyphenyl; 3,4-dimethoxyphenyl; ethoxyphenyl; 3,4-diethoxyphenyl; iso-propoxyphenyl; methoxy ethoxy-phenyl; 3-methoxy-4-(2-methoxy ethoxy)-phenyl; fluoro-(iso-propoxy)-phenyl; 3-methoxy-4-hydroxy phenyl; fluoro-hydroxy-phenyl; hydroxy-fluoroalkyl-phenyl; 2,2-difluoro-benzo[1,3]dioxolo; benzene sulfonamide; N,N-dimethylbenzenesulfonamide; 3-(pyrrolidine-1-sulfonyl)-phenyl; N-(phen-3-yl)-methanesulfonamide; N-methyl-N-phen-3-yl-methanesulfonamide; 3-methanesulfonylphenyl; 3- or 4-benzamide; 3- or 4-N-methyl-benzamide; 3- or 4-N,N-dimethyl-benzamide; pyrazol-phenyl; imidazol-phenyl; pyridyl; alkylpyridyl; alkoxypyridyl; cycloalkoxypyridyl; (haloalkoxy)pyridyl; cycloalkylalkoxypyridyl; alkoxyalkylpyridyl; alkoxyalkoxypyridyl; (alkyl)(alkoxyalkoxy)pyridyl; benzyloxyalkoxypyridyl; hydroxyalkylpyridyl; hydroxycycloalkylpyridyl; hydroxyfluoroalkylpyridyl; aminoalkylpyridyl; alkyl-sulfonyl pyridyl; hydroxyalkoxypyridyl; alkoxycarbonylpyridyl; aminopyridyl; alkylaminopyridyl; dialkylaminopyridyl; cycloalkylaminopyridyl; (N-alkyl-N-cycloalkylamino)pyridyl; (alkyl)(amino)pyridyl; (halo)(amino)pyridyl; (halo)(alkylamino)pyridyl; (halo)(dialkylamino)pyridyl; (halo)(hydroxyalkyl)pyridyl; (alkoxy)(alkyl)pyridyl; (alkoxy)(alkoxy)pyridyl; (alkoxy)(alkoxyalkyl)pyridyl; (alkoxy)(deuteroalkoxy-alkyl)pyridyl; (alkoxy)(hydroxyalkyl)pyridyl; (haloalkoxy)(alkyl)pyridyl; (haloalkoxy)(hydroxyalkyl)pyridyl; (alkoxyalkoxy)(hydroxyalkyl)pyridyl; (alkyl)(alkylamino)pyridyl; (alkyl)(di-alkylamino)pyridyl; cycloaminopyridyl; cyclic ether-substituted amino-pyridyl; hydroxy-cycloaminopyridyl; loweralkoxy-cycloaminopyridyl; hydroxyalkylaminopyridyl; (alkyl)(hydroxy)pyridyl; (hydroxyalkyl)(alkylamino)pyridyl; (hydroxyalkyl)(amino)pyridyl; (alkoxyalkyl)(alkylamino)pyridyl; (alkoxyalkyl)(amino)pyridyl; amino-haloloweralkyl-pyridyl; alkylamino-haloalkyl-pyridyl; haloalkyl-deuteroloweralkylamino-pyridyl; haloalkylpyridinyl; cyanoalkylpyridinyl; cyanocycloalkylpyridinyl; halopyridyl; halo-alkoxy-pyridyl; carbamoylpyridyl; alkyl-substituted carbamoylpyridyl; piperazinylpyridyl; N-alkylpiperazinylpyridyl; alkylsulfonamidopyridyl; dialkylsulfonamidopyridyl; (alkylsulfonamido)(alkyl)pyridyl; (alkylsulfonamido)(halo)pyridyl; (alkylsulfonamidoalkyl)pyridyl; dialkylsulfonamido(alkyl)pyridyl; 3H-tetrazol-5-yl pyridyl; alkylcarbonylaminoalkylpyridyl; (halo)(alkylcarbonylamino)pyridyl; (alkoxy)(alkylcarbonylamino)pyridyl; (alkoxy)(alkylcarbonyl-N-alkylamino)pyridyl; (alkoxy)(nitro)pyridyl; (alkoxy)(cyano)pyridyl; (alkoxy)(amino)pyridyl; (alkoxy)(alkylamino)pyridyl; (alkoxyalkyl)(alkylamino)pyridyl; (alkoxy)(alkylaminocarbonyl)pyridyl; (alkoxyalkyl)(alkylamino)pyridyl; (amino)(alkylaminocarbonyl)pyridyl; (amino)(alkoxyalkylaminocarbonyl)pyridyl; (alkylamino)(alkylaminocarbonyl)pyridyl; (alkoxy)(aminocarbonyl)pyridyl; (alkoxy)(hydroxycarbonyl)pyridyl; morpholinylpyridinyl; (1H-pyrazolyl)-pyridinyl; loweralkylsubstituted(1H-imidazol-1-yl)-pyridinyl; pyrimidinyl; di-loweralkylaminopyrimidinyl; alkoxypyrimidinyl; di-alkoxypyrimidinyl; (alkylamino)(alkoxy)pyrimidinyl; cycloaminopyrimidinyl; aminopyrimidinyl; alkylaminopyrimidinyl; dialkylaminopyrimidinyl; 1H-pyrrolo[2,3-b]pyridinyl; 1-methyl-1H-pyrrolo[2,3-b]pyridinyl; pyrazinyl; pyrazolyl; hydroxyalkylpyrazolyl; 1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazolyl; quinolinyl; 2-oxo-2,3-dihydro-1H-indol-5-yl; 1-methyl-2,3-dihydro-1H-indol-5-yl; 1H-imidazo[4,5-b]pyridin-2(3H)-one-6-yl; 3H-imidazo[4,5-b]pyridin-6-yl; (3-methyl)-3H-imidazo[4,5-b]pyridin-6-yl; (2-methyl)-(3-methyl)-3H-imidazo[4,5-b]pyridin-6-yl; (2-methoxy)-(3-methyl)-3H-imidazo[4,5-b]pyridin-6-yl; (2-dimethylamino)-(3-methyl)-3H-imidazo[4,5-b]pyridin-6-yl; 3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl; (3-methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl; H-pyrrolo[3,2-b]pyridin-6-yl; 1-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl; 2-oxo-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-6-yl; 1-methyl-2-oxo-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-6-yl; 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl; 4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl; 1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl; 2-oxo-1,4-dihydro-2H-pyrido[3,2-d][1,3]oxazin-7-yl; and 1-ethyl-2-oxo-1,4-dihydro-2H-pyrido[3,2-d][1,3]oxazin-7-yl; or a pharmaceutically acceptable salt thereof. 
     
     
         4 . A compound selected from:
 8-(3,4-Dimethoxy-phenyl)-1-(1,5-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(2-ethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-3-methyl-1-(2-methyl-2H-pyrazol-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(2,4-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(3,4-dimethoxy-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,4-Dimethyl-2H-pyrazol-3-yl)-8-(6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Methoxy-pyridin-3-yl)-3-methyl-1-(2-methyl-2H-pyrazol-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,5-Dimethyl-2H-pyrazol-3-yl)-8-(6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Methoxy-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2-Ethyl-2H-pyrazol-3-yl)-8-(6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-8-(6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,5-Dimethyl-1H-pyrazol-4-yl)-8-(6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethoxy-pyridin-3-yl)-3-methyl-1-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethoxy-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethoxy-pyridin-3-yl)-1-(2-ethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethoxy-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,5-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethoxy-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-ethoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{4-[8-(6-Ethoxy-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3-methyl-pyrazol-1-yl}-N,N-dimethyl-acetamide;   8-(6-Ethoxy-pyridin-3-yl)-3-methyl-1-[3-methyl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-pyrazol-4-yl]-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethoxy-pyridin-3-yl)-1-[1-(2-methoxy-ethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{4-[8-(6-Ethoxy-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3,5-dimethyl-pyrazol-1-yl}-N,N-dimethyl-acetamide;   8-(6-Dimethylamino-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Dimethylamino-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Dimethylamino-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Dimethylamino-pyridin-3-yl)-1-(1,5-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Dimethylamino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Dimethylamino-pyridin-3-yl)-1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Dimethylamino-pyridin-3-yl)-3-methyl-1-(2-methyl-2H-pyrazol-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Dimethylamino-pyridin-3-yl)-1-(2-ethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-dimethylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Azetidin-1-yl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Azetidin-1-yl-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2-Dimethylamino-pyrimidin-5-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2-Dimethylamino-pyrimidin-5-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(2-dimethylamino-pyrimidin-5-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2-Dimethylamino-pyrimidin-5-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,5-Dimethyl-2H-pyrazol-3-yl)-3-methyl-8-(6-methyl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(6-methyl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-1-(2-methyl-2H-pyrazol-3-yl)-8-(6-trifluoromethyl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,5-Dimethyl-2H-pyrazol-3-yl)-3-methyl-8-(6-trifluoromethyl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,5-Dimethyl-2H-pyrazol-3-yl)-8-(2-fluoro-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-8-pyridin-3-yl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-pyridin-3-yl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2-Fluoro-pyridin-4-yl)-3-methyl-1-(2-methyl-2H-pyrazol-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-fluoro-6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridine-2-carboxylic acid amide;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridine-2-carboxylic acid methylamide;   5-[3-Methyl-2-oxo-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridine-2-carboxylic acid methylamide;   5-[1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridine-2-carboxylic acid methylamide;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Hydroxymethyl-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Hydroxymethyl-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(2-methoxy-pyrimidin-5-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(2-methoxy-pyrimidin-5-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(2-methoxy-pyrimidin-5-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-(2-methoxy-ethoxy)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-[6-(2-Benzyloxy-ethoxy)-pyridin-3-yl]-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-[6-(3-Benzyloxy-propoxy)-pyridin-3-yl]-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-[6-(2-Hydroxy-ethylamino)-pyridin-3-yl]-3-methyl-1-(2-methyl-2H-pyrazol-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-(2-hydroxy-ethylamino)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-methanesulfonyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(5-methyl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-trifluoromethyl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{4-[8-(6-Amino-5-trifluoromethyl-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3,5-dimethyl-pyrazol-1-yl}-N,N-dimethyl-acetamide;   8-(6-Amino-5-trifluoromethyl-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-trifluoromethyl-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-trifluoromethyl-pyridin-3-yl)-1-(3,5-dimethyl-isoxazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-trifluoromethyl-pyridin-3-yl)-1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-pyrimidin-5-yl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Diethoxy-phenyl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Diethoxy-phenyl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3-Ethoxy-4-methoxy-phenyl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3-Ethoxy-4-methoxy-phenyl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(3-ethoxy-4-methoxy-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(4-Ethoxy-3-methoxy-phenyl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(4-Ethoxy-3-methoxy-phenyl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(4-ethoxy-3-methoxy-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[3-methoxy-4-(2-methoxy-ethoxy)-phenyl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-[3-methoxy-4-(2-methoxy-ethoxy)-phenyl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(4-Hydroxy-3-methoxy-phenyl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(3-hydroxy-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3-Hydroxy-phenyl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(3-fluoro-5-hydroxy-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(3-hydroxy-5-trifluoromethyl-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2,2-Difluoro-benzo[1,3]dioxol-4-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-phenyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-8-phenyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N,N-Dimethyl-2-[3-methyl-4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-pyrazol-1-yl]-acetamide;   2-[3,5-Dimethyl-4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-quinolin-3-yl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N-methyl-benzenesulfonamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(3-methanesulfonyl-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   4-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-benzamide;   8-(6-Cyclopropylmethoxy-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   4-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N-methyl-benzamide;   4-[1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N-methyl-benzamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-[3-(pyrrolidine-1-sulfonyl)-phenyl]-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-benzamide;   N-{3-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-phenyl}-methanesulfonamide;   4-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N,N-dimethyl-benzamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(2-oxo-2,3-dihydro-1H-indol-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(1-methyl-2,3-dihydro-1H-indol-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(4-pyrazol-1-yl-phenyl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N,N-Dimethyl-2-{3-methyl-4-[3-methyl-2-oxo-8-(4-pyrazol-1-yl-phenyl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-acetamide;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-(4-pyrazol-1-yl-phenyl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{3,5-Dimethyl-4-[3-methyl-2-oxo-8-(4-pyrazol-1-yl-phenyl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-N,N-dimethyl-acetamide;   2-{3,5-Dimethyl-4-[3-methyl-2-oxo-8-(4-pyrazol-1-yl-phenyl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-N,N-dimethyl-acetamide;   N-Ethyl-N-methyl-2-{3-methyl-4-[3-methyl-2-oxo-8-(4-pyrazol-1-yl-phenyl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-acetamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(2-ethoxy-pyrimidin-5-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N,N-dimethyl-benzenesulfonamide;   N,N-Dimethyl-3-[3-methyl-2-oxo-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-benzenesulfonamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(6-propoxy-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{4-[8-(5-Ethoxy-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3-methyl-pyrazol-1-yl}-N,N-dimethyl-acetamide;   8-(5-Ethoxy-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-ethoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,4-Dimethyl-2H-pyrazol-3-yl)-8-(5-ethoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(3-ethoxy-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-isopropoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-isopropoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,4-Dimethyl-2H-pyrazol-3-yl)-8-(5-isopropoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(5-isopropoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N-Ethyl-2-{4-[8-(5-isopropoxy-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3-methyl-pyrazol-1-yl}-N-methyl-acetamide   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(2-methoxy-ethoxy)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-[5-(2-methoxy-ethoxy)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Cyclobutoxy-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{4-[8-(5-Cyclobutoxy-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3,5-dimethyl-pyrazol-1-yl}-N,N-dimethyl-acetamide;   8-(5-Cyclopropylmethoxy-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-methoxy-pyridin-3-yl}-N-methyl-acetamide;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-ethoxy-pyridin-3-yl}-N-methyl-acetamide;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-methoxy-pyridin-3-yl}-acetamide;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-ethoxy-pyridin-3-yl}-acetamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-methoxy-5-nitro-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(1-ethyl-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[1-(2-methoxy-ethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2-Dimethylamino-3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(2-methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2,3-Dimethyl-3H-imidazo[4,5-b]pyridin-6-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-methyl-pyridin-3-yl}-N-methyl-methanesulfonamide;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-methyl-pyridin-3-yl}-methanesulfonamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[4-(1H-imidazol-2-yl)-phenyl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-[6-(2-methyl-imidazol-1-yl)-pyridin-3-yl]-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(6-pyrazol-1-yl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(2-methylamino-pyrimidin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-8-(2-methylamino-pyrimidin-5-yl)-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2-Amino-pyrimidin-5-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2-Amino-pyrimidin-5-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(3-isopropoxy-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(2-fluoro-3-isopropoxy-phenyl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-isopropoxy-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(5-isopropoxy-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethoxy-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethoxy-6-methyl-pyridin-3-yl)-1-[1-(2-methoxy-ethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{4-[8-(5-Ethoxy-6-methyl-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3,5-dimethyl-pyrazol-1-yl}-N,N-dimethyl-acetamide;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-[5-(2-methoxy-ethoxy)-6-methyl-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(2-methoxy-ethoxy)-6-methyl-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethylamino-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-ethylamino-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-methyl-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-methyl-pyridin-3-yl)-1-[1-(2-methoxy-ethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{4-[8-(5-Ethylamino-6-methyl-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3,5-dimethyl-pyrazol-1-yl}-N,N-dimethyl-acetamide;   8-(5-Amino-6-methyl-pyridin-3-yl)-1-(3-chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-methyl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-methoxy-pyridin-3-yl)-1-(3-chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-ethylamino-6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-methoxy-pyridin-3-yl)-1-[1-(2-methoxy-ethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(2-ethoxy-pyridin-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(2-isopropoxy-pyridin-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-isopropoxy-6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethoxy-6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Diethylamino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(6-pyrrolidin-1-yl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-(ethyl-methyl-amino)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-[6-(Ethyl-methyl-amino)-pyridin-3-yl]-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-[6-(Ethyl-methyl-amino)-pyridin-3-yl]-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(1H-pyrrolo[3,2-b]pyridin-6-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridine-2-carboxylic acid methyl ester;   {4-[8-(6-Methoxy-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3-methyl-pyrazol-1-yl}-acetic acid;   2-{4-[8-(6-Methoxy-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3-methyl-pyrazol-1-yl}-N,N-dimethyl-acetamide;   1-[1-(2-Hydroxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-8-(6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethoxy-pyridin-3-yl)-1-[1-(2-hydroxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-8-(6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-(2-hydroxy-ethoxy)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-(3-hydroxy-propoxy)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-methoxy-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethoxy-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   5-[1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridine-2-carboxylic acid amide;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-pyridin-2-yl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-pyridin-2-yl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-pyrazin-2-yl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N-{3-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-phenyl}-N-methyl-methanesulfonamide;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-(6-methylamino-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(6-methylamino-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N,N-Dimethyl-2-{3-methyl-4-[3-methyl-8-(6-methylamino-pyridin-3-yl)-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-acetamide;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-(6-methylamino-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-8-(6-methylamino-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-8-(5-methyl-6-methylamino-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-methanesulfonamide;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-N-methyl-methanesulfonamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-[6-(2H-tetrazol-5-yl)-pyridin-3-yl]-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridine-2-carbonitrile;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-methoxy-nicotinic acid;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-methoxy-N-methyl-nicotinamide;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-methoxy-nicotinamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(6-piperazin-1-yl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-methoxy-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-pyridin-3-yl-1,3-dihydro-imidazo[4,5-c]quinoline-2-thione;   8-(3,4-Dimethoxy-phenyl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinoline-2-thione;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(1-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethoxy-pyridin-3-yl)-1-[1-(2-methoxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-2-methoxy-nicotinonitrile;   8-(6-Ethoxy-pyridin-3-yl)-1-{3-methyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-pyrazol-4-yl}-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-1-{3-methyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-pyrazol-4-yl}-8-phenyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N-Ethyl-N-methyl-2-[3-methyl-4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-pyrazol-1-yl]-acetamide;   2-{4-[8-(6-Ethoxy-pyridin-3-yl)-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-3-methyl-pyrazol-1-yl}-N-ethyl-N-methyl-acetamide;   N-(2-Methoxy-ethyl)-N-methyl-2-[3-methyl-4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-pyrazol-1-yl]-acetamide;   1-[1-(2-Azetidin-1-yl-2-oxo-ethyl)-3-methyl-1H-pyrazol-4-yl]-8-(6-ethoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N,N-Diethyl-2-{3-methyl-4-[3-methyl-8-(6-methyl-pyridin-3-yl)-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-acetamide;   N-Ethyl-N-methyl-2-{3-methyl-4-[3-methyl-2-oxo-8-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-acetamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Fluoro-6-methylamino-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-fluoro-6-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Fluoro-6-methylamino-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-fluoro-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-fluoro-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-fluoro-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-8-(6-trideuteromethylamino-5-trifluoromethyl-pyridin-3-yl)-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-8-(6-methylamino-5-trifluoromethyl-pyridin-3-yl)-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-(6-methylamino-5-trifluoromethyl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(6-methylamino-5-trifluoromethyl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethylamino-5-trifluoromethyl-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethylamino-5-trifluoromethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Chloro-6-methylamino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Chloro-6-methylamino-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Chloro-6-methylamino-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Chloro-6-methylamino-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Chloro-6-methylamino-pyridin-3-yl)-1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Chloro-6-methylamino-pyridin-3-yl)-1-(3,5-dimethyl-isoxazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Chloro-6-ethylamino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-chloro-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-chloro-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-chloro-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-chloro-pyridin-3-yl)-1-(3,5-dimethyl-isoxazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-fluoro-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-fluoro-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-fluoro-pyridin-3-yl)-1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(6-fluoro-5-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-fluoro-5-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Dimethylamino-6-fluoro-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-chloro-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-chloro-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-chloro-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Chloro-5-ethylamino-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Chloro-5-ethylamino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Chloro-5-ethylamino-pyridin-3-yl)-1-(3,5-dimethyl-isoxazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-fluoro-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3,5-Dimethyl-isoxazol-4-yl)-8-(5-ethylamino-6-fluoro-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethylamino-6-hydroxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-hydroxymethyl-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-hydroxymethyl-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-hydroxymethyl-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethylamino-6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-methoxymethyl-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-5-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Hydroxymethyl-5-methylamino-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-5-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Hydroxymethyl-5-methylamino-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-5-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-methoxymethyl-5-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-methoxymethyl-5-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethyl-5-ethylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethyl-5-isopropylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(6-methyl-5-methylamino-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Dimethylamino-6-methyl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(ethyl-methyl-amino)-6-methyl-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-ethoxymethyl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-ethoxymethyl-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-ethoxymethyl-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-ethoxymethyl-pyridin-3-yl)-1-(3-chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-ethoxymethyl-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethoxymethyl-6-ethylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-methoxymethyl-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-methoxymethyl-pyridin-3-yl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-methoxymethyl-pyridin-3-yl)-1-(3-chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-hydroxymethyl-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-hydroxymethyl-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Amino-5-hydroxymethyl-pyridin-3-yl)-1-(3-chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-(1-methyl-2-oxo-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-6-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Hydroxymethyl-6-methylamino-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Cyclobutylamino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(isopropyl-methyl-amino)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-[5-(Cyclobutyl-methyl-amino)-pyridin-3-yl]-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(5-morpholin-4-yl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,5-Dimethyl-2H-pyrazol-3-yl)-3-methyl-8-(5-morpholin-4-yl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-[1-(2-Hydroxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-3-methyl-8-(5-morpholin-4-yl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(ethyl-methyl-amino)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-isopropylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Isopropylamino-pyridin-3-yl)-1-[1-(2-methoxy-ethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Dimethylamino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Azetidin-1-yl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-(5-methylamino-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-(5-methylamino-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(2-fluoro-ethoxy)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(2-fluoro-1-fluoromethyl-ethoxy)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Difluoromethoxy-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-methoxy-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-hydroxy-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(2,5-Dimethyl-2H-pyrazol-3-yl)-8-(5-hydroxy-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethyl-5-isopropoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethoxy-6-ethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethyl-5-hydroxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(2-fluoro-1-fluoromethyl-ethoxy)-6-methyl-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-5-isopropoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-isopropoxy-6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(5-isopropoxy-6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(2-fluoro-1-fluoromethyl-ethoxy)-6-hydroxymethyl-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-5-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Hydroxymethyl-5-methoxy-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-hydroxymethyl-5-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-methoxy-6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-8-(5-methoxy-6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(5-methoxy-6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-methoxy-6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-ethoxymethyl-5-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethoxymethyl-5-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethoxy-6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethoxy-6-methoxymethyl-pyridin-3-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethoxy-6-trideuteromethoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-methoxy-6-trideuteromethoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-hydroxymethyl-6-methoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-methoxy-5-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-methoxy-5-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(6-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5,6-Dimethoxy-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-[1-(2-Azetidin-1-yl-2-oxo-ethyl)-3-methyl-1H-pyrazol-4-yl]-8-(5-isopropoxy-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethylamino-5-methoxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(6-Ethylamino-5-methoxymethyl-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2-Dimethylamino-pyrimidin-5-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-6-ethyl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(6-ethyl-5-nitro-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethylamino-6-methyl-pyridin-3-yl)-1-[1-(2-hydroxy-ethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-[1-(2-Hydroxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-8-(5-methoxy-6-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Ethoxy-6-methyl-pyridin-3-yl)-1-[1-(2-hydroxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-((R)-3-hydroxy-pyrrolidin-1-yl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-((S)-3-hydroxy-pyrrolidin-1-yl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-((R)-3-methoxy-pyrrolidin-1-yl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-((S)-3-methoxy-pyrrolidin-1-yl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-[6-(tetrahydro-pyran-4-ylamino)-pyridin-3-yl]-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-[5-(1-Hydroxy-1-methyl-ethyl)-pyridin-3-yl]-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(1-hydroxy-1-methyl-ethyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-[5-(1-hydroxy-1-methyl-ethyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-[5-(1-hydroxy-1-methyl-ethyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(1-ethyl-1-hydroxy-propyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   (rac)-1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(1-hydroxy-ethyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(1-hydroxy-cyclopentyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-[5-(2-Fluoro-1-fluoromethyl-1-hydroxy-ethyl)-pyridin-3-yl]-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-2-methyl-propionitrile;   2-{5-[1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-2-methyl-propionitrile;   2-{5-[1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-2-methyl-propionitrile;   1-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-cyclobutanecarbonitrile; 1-{5-[1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-cyclobutanecarbonitrile;   N-{2-Chloro-5-[1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-acetamide;   N-{2-Chloro-5-[1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-methanesulfonamide;   2-Amino-5-[1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N-methyl-nicotinamide;   2-Amino-5-[1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N-methyl-nicotinamide;   2-Amino-5-[1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N-isopropyl-nicotinamide;   2-Amino-5-[1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N-(2-methoxy-ethyl)-nicotinamide;   2-Amino-N-ethyl-5-[1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-nicotinamide;   2-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-N-methyl-acetamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(2-hydroxy-1,1-dimethyl-ethyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   2-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-yl}-2-methyl-propionic acid methyl ester;   8-(5-Aminomethyl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N-{5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-pyridin-3-ylmethyl}-acetamide;   8-(5-Aminomethyl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2,4-Dimethoxy-pyrimidin-5-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2,4-Dimethoxy-pyrimidin-5-yl)-1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(2,4-Dimethoxy-pyrimidin-5-yl)-1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(2-ethylamino-4-methoxy-pyrimidin-5-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(4-methoxy-2-methylamino-pyrimidin-5-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(1-ethyl-2-oxo-1,4-dihydro-2H-pyrido[3,2-d][1,3]oxazin-7-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Chloro-6-hydroxymethyl-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(1-methoxy-1-methyl-ethyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[5-(1-ethoxy-1-methyl-ethyl)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-8-(6-(methylamino)pyridin-3-yl)-1H-imidazo[4,5-c]quinoline-2(3H)-thione;   5-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N-ethyl-2-methylamino-nicotinamide;   N-Ethyl-2-methylamino-5-[3-methyl-2-oxo-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-nicotinamide;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-ethoxy-6-hydroxymethyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[6-hydroxymethyl-5-(2-methoxy-ethoxy)-pyridin-3-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Amino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-ethyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Allyl-8-(5-amino-pyridin-3-yl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   N,N-Diethyl-2-{3-methyl-4-[3-methyl-2-oxo-8-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-acetamide;   {3-Methyl-4-[3-methyl-2-oxo-8-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-pyrazol-1-yl}-acetic acid;   1-[1-(2-Azetidin-1-yl-2-oxo-ethyl)-3-methyl-1H-pyrazol-4-yl]-3-methyl-8-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-1-[3-methyl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-pyrazol-4-yl]-8-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-1-[3-methyl-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1H-pyrazol-4-yl]-8-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   3-Methyl-1-{3-methyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-pyrazol-4-yl}-8-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Isopropyl-3-methyl-1H-pyrazol-4-yl)-8-(5-methoxymethyl-6-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-8-(5-methoxymethyl-6-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-(5-methoxymethyl-6-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   1-(3-Chloro-1-methyl-1H-pyrazol-4-yl)-8-(5-methoxymethyl-6-methylamino-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(5-Methoxymethyl-6-methylamino-pyridin-3-yl)-3-methyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one;   8-(3,4-dimethoxy-phenyl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-1,3-dihydro-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-ethyl-1,3-dihydro-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(2,5-dimethyl-2H-pyrazol-3-yl)-1,3-dihydro-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-methyl-1,3-dihydro-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-one;   8-(3,4-Dimethoxy-phenyl)-1-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-one;   
       or a pharmaceutically acceptable salt thereof. 
     
     
         5 . A compound, or a pharmaceutically acceptable salt thereof, selected from: 
       
         
           
           
               
               
           
         
       
     
     
         6 . A pharmaceutical composition comprising a compound of  claim 1 , or a pharmaceutically acceptable salt thereof, and optionally a further therapeutic agent, together with a pharmaceutically acceptable carrier. 
     
     
         7 . A method of treatment of a disease comprising administration of a prophylactically or therapeutically effective amount of a compound of  claim 1 , or a pharmaceutically acceptable salt thereof, to a warm-blooded animal in need of such treatment, wherein the disease is selected from a proliferative disease, a benign or malignant tumor, a carcinoma of the brain, kidney, liver, adrenal gland, bladder, breast, stomach, gastric tumors, ovaries, colon, rectum, prostate, pancreas, lung, vagina or thyroid, sarcoma, glioblastomas, multiple myeloma or gastrointestinal cancer, colon carcinoma or colorectal adenoma or a tumor of the neck or head, an epidermal hyperproliferation, psoriasis, prostate hyperplasia, a neoplasia, a neoplasia of epithelial character, lymphomas, a mammary carcinoma or a leukemia, Cowden syndrome, Lhermitte-Dudos disease or Bannayan-Zonana syndrome, basal cell carcinoma, squamous cell carcinoma, actinic keratosis, psoriasis, skin fibrosis, scleroderma and keloids. 
     
     
         8 . The method of  claim 7  wherein the administration is by topical application.