Tricalcium Phosphate Coarse Particle Compositions and Methods for Making the Same

Abstract

Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.

1 . A method of making a tricalcium phosphate coarse particle composition, said method comprising:
 (a) converting an initial tricalcium phosphate particulate composition to hydroxyapatite;   (b) sintering said hydroxyapatite to produce a second tricalcium phosphate composition; and   (c) mechanically manipulating said second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition.   
     
     
         2 - 12 . (canceled) 
     
     
         13 . A tricalcium phosphate coarse particle composition produced according to the method comprising:
 (a) converting an initial tricalcium phosphate particulate composition to hydroxyapatite;   (b) sintering said hydroxyapatite to produce a second tricalcium phosphate composition; and   (c) mechanically manipulating said second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition.   
     
     
         14 . (canceled) 
     
     
         15 . A method of producing a flowable composition that sets into a calcium phosphate containing product, said method comprising:
 combining:   (a) a setting fluid; and   (b) a dry reactant component comprising a tricalcium phosphate coarse particle composition comprising tricalcium phosphate particles ranging in size from 38 to 212 μm;   in a ratio sufficient to produce said flowable material.   
     
     
         16 . The method according to  claim 15 , wherein said dry reactant component comprises a fine calcium phosphate particulate composition having a mean particle size of less than 8 μm and narrow particle size distribution. 
     
     
         17 . The method according to  claim 16 , wherein the ratio of said fine to coarse compositions in said dry reactant component ranges from 1 to 10. 
     
     
         18 . The method according to  claim 15 , wherein at least one of said setting fluid and dry reactants comprises a cyclodextrin. 
     
     
         19 . A flowable composition that sets into a calcium phosphate containing product, wherein said composition is produced by the method according to  claim 15 . 
     
     
         20 . The composition according to  claim 19 , wherein said composition comprises a cyclodextrin. 
     
     
         21 . A method of repairing a hard tissue defect, said method comprising:
 applying to the site of said defect a flowable composition that sets into a calcium phosphate containing product, wherein said composition is produced by the method according to  claim 15 .   
     
     
         22 - 24 . (canceled)