MODIFICATIONS OF SOLID 3-sn-PHOSPHOGLYCERIDES

Abstract

Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A 2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.

1 . A drug delivery composition comprising
 a lipid matrix, wherein the lipid matrix includes less than 1% moisture, wherein the lipid matrix comprises lysophosphoglyceride, monoglyceride and fatty acid, and wherein the molar ratio of lysophosphoglyceride:the sum of monoglyceride and fatty acid in the lipid matrix is between 1:3 and 1:12, and   carbohydrate and/or starch,   wherein the drug delivery composition is in a powdered form.   
     
     
         2 . The drug delivery composition of  claim 1 , wherein the composition includes carbohydrate and starch. 
     
     
         3 . The drug delivery composition of  claim 1 , wherein the carbohydrate includes one or more sugars. 
     
     
         4 . The drug delivery composition of  claim 1 , wherein the composition further includes one or more proteins. 
     
     
         5 . The drug delivery composition of  claim 1 , wherein the composition further includes one or more flavors. 
     
     
         6 . The drug delivery composition of  claim 1 , wherein the lipid matrix comprises from about 0 to about 1 moles of water per mole of lipid. 
     
     
         7 . The drug delivery composition of  claim 6 , wherein the lipid matrix comprises about 1 moles of water per mole of lipid. 
     
     
         8 . The drug delivery composition of  claim 6 , wherein the lipid matrix comprises about 0.5 moles of water per mole of lipid. 
     
     
         9 . The drug delivery composition of  claim 1  wherein the molar ratio of lysophosphoglyceride:the sum of monoglyceride and fatty acid in the lipid matrix is between 1:5 and 1:6. 
     
     
         10 . The drug delivery composition of  claim 9  wherein the lipid matrix has a lysophosphoglyceride:monoglyceride:fatty acid molar ratio between 1:4:2 and 1:2:4. 
     
     
         11 . The drug delivery composition of  claim 10  wherein the lipid matrix has a lysophosphoglyceride:monoglyceride:fatty acid molar ratio selected from the group consisting of 1:4:2, 1:3:3 and 1:3:2. 
     
     
         12 . The drug delivery composition of  claim 1 , wherein the lysophosphoglyceride is lysophosphatidylcholine. 
     
     
         13 . The drug delivery composition of any one of  claims 1 - 12 , further comprising one or more water soluble or water insoluble pharmaceutical compounds. 
     
     
         14 . A method for administering a drug to a subject comprising
 administering the drug delivery composition of  claim 13  to the subject.   
     
     
         15 . A method for making a product comprising
 providing a lipid matrix comprising lysophosphoglyceride, monoglyceride and fatty acid, wherein the molar ratio of lysophosphoglyceride:the sum of monoglyceride and fatty acid in the lipid matrix is between 1:3 and 1:12, and   mixing the lipid matrix with one or more comestible components selected from carbohydrate and starch to form a powder.   
     
     
         16 . The method of  claim 15 , further comprising mixing the lipid matrix with one or more water soluble or water insoluble pharmaceutical compounds. 
     
     
         17 . The method of  claim 15 , wherein the lipid matrix has a lysophosphoglyceride:monoglyceride:fatty acid molar ratio between 1:4:2 and 1:2:4. 
     
     
         18 . A powdered composition formed by the method of  claim 15 . 
     
     
         19 . A powdered composition formed by the method of  claim 16 . 
     
     
         20 . A powdered composition formed by the method of  claim 17 .