Dried product and a process for manufacturing the product

Abstract

A dried product of an extract from inflammatory rabbit skin inoculated with vaccinia virus having an inhibitory activity for the production of a kallikrein-like substance is produced by admixing the extract with a saccharide, sugar alcohol or ascorbic acid before reaching dryness, and then drying the admixture to a solid form such as granules. The dried product may be employed to produce a solid preparation for oral administration, such as tablets, having an inhibitory activity for the production of a kallikrein-like substance.

1 - 2 . (canceled) 
     
     
         3 . A dried product as claimed in  claim 14  wherein said at least one member is added to and mixed with an extract from inflammatory rabbit skin inoculated with vaccinia virus and then the mixture is concentrated and dried. 
     
     
         4 . A dried product as claimed in  claim 14  wherein an extract from inflammatory rabbit skin inoculated with vaccinia virus is concentrated and, before the concentrated extract reaches dryness, said at least one member is added to and mixed with the concentrated liquid extract and then the mixture is dried. 
     
     
         5 . A dried product as claimed in  claim 4  wherein the concentration of the extract is carried out at a pH of 8.8 to 9.7. 
     
     
         6 . A dried product as claimed in  claim 14  wherein the drying of the extract is carried out at a pH of 8.8 to 9.5. 
     
     
         7 . A dried product as claimed in  claim 14  wherein said at least one member is selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin and dextran. 
     
     
         8 . A dried product as claimed in  claim 14  wherein said at least one member is selected from the group consisting of mannitol, maltitol, lactitol, palatinit and sorbitol. 
     
     
         9 . A dried product as claimed in  claim 14  wherein the amount of said at least one member is at least 0.1% by weight, based upon the weight of the extract and said at least one member. 
     
     
         10 . A dried product as claimed in  claim 14  wherein said drying comprises vacuum drying. 
     
     
         11 . A dried product as claimed in  claim 14  wherein said mixture is granulated and dried to obtain granules. 
     
     
         12 . A dried product as claimed in  claim 11  wherein said granules are formed into tablets. 
     
     
         13 . A dried product as claimed in  claim 12  wherein said tablets are spray coated with a coating solution. 
     
     
         14 . A dried product having an inhibitory activity for the production of a kallikrein comprising a dried extract from inflammatory rabbit skin inoculated with vaccinia virus obtained by admixing a liquid extract from inflammatory rabbit skin inoculated with vaccinia virus with at least one member selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin, dextran, mannitol, maltitol, lactitol, palatinit, sorbitol, and ascorbic acid to obtain a mixture, and then drying the mixture to obtain a dried product having an inhibitory activity for the production of a kallikrein, wherein drying of said extract is carried out at a pH of 8.8 to 9.7. 
     
     
         15 . (canceled) 
     
     
         16 . A solid preparation for oral administration comprising a dried product of  claim 14 . 
     
     
         17 . A dried product having an inhibitory activity for the production of a kallikrein comprising a co-dried admixture of a liquid extract from inflammatory rabbit skin inoculated with vaccinia virus and at least one member selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin, dextran, mannitol, maltitol, lactitol, palatinit, sorbitol, and ascorbic acid, wherein drying of said extract is carried out at a pH of 8.8 to 9.7 to obtain a dried product having an inhibitory activity for the production of a kallikrein. 
     
     
         18 . A dried product as claimed in  claim 17  wherein said at least one member is selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin and dextran. 
     
     
         19 . A dried product as claimed in  claim 17  wherein said at least one member is selected from the group consisting of mannitol, maltitol, lactitol, palatinit and sorbitol. 
     
     
         20 . A solid preparation for oral administration comprising granules of a dried product as claimed in  claim 17 . 
     
     
         21 . A solid preparation for oral administration as claimed in  claim 20 , wherein the preparation is a tablet. 
     
     
         22 . A solid preparation having an inhibitory activity for the production of a kallikrein for oral administration comprising an extract from inflammatory rabbit skin inoculated with vaccinia virus as an effective ingredient which is manufactured using dried granules prepared in such a manner that a liquid extract is concentrated and, before the concentrated liquid extract reaches dryness, an excipient comprising at least one member selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin, dextran, mannitol, maltitol, lactitol, palatinit, sorbitol, and ascorbic acid is added to the concentrated liquid extract and kneaded therewith, and then the kneaded mixture is granulated and dried to obtain a dried product having an inhibitory activity for the production of a kallikrein, wherein drying of said extract is carried out at a pH of 8.8 to 9.7. 
     
     
         23 . A solid preparation as claimed in  claim 22  wherein concentration of the extract is carried out at a pH of 8.8 to 9.7. 
     
     
         24 . A solid preparation as claimed in  claim 22  wherein the drying of said extract is carried out at a pH of 8.8 to 9.5. 
     
     
         25 . A solid preparation as claimed in  claim 22  wherein the drying of said extract is at a pH of 8.8 to 9.3. 
     
     
         26 . A solid preparation as  claim 22  wherein the granules have at least 0.1% by weight of said at least one member.