Inhibitors of histone deacetylase and prodrugs thereof

Abstract

The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

1 .- 34 . (canceled) 
     
     
         35 . A compound selected from the group consisting of
 N-hydroxy-2-(4-(4-(2,4,5-trifluorophenyl)butyl)phenyl)acetamide;   2-(4-(4-(benzo[c][1,2,5]oxadiazol-5-yl)but-3-ynyl)phenyl)-N-hydroxyacetamide;   N-Hydroxy-2-(3-(4-phenylbutyl)phenyl)acetamide;   N-hydroxy-2-(4-(4-(4-(trifluoromethyl)phenyl)butyl)phenyl)acetamide;   2-(4-(4-(1H-indol-5-yl)butyl)phenyl)-N-hydroxyacetamide;   N-hydroxy-2-(4-(4-(3-(trifluoromethyl)phenyl)butyl)phenyl)acetamide;   N-hydroxy-2-(4-(4-(2-(trifluoromethyl)phenyl)butyl)phenyl)acetamide;   N-hydroxy-2-(4-(4-(imidazo[1,2-a]pyridin-6-yl)butyl)phenyl)acetamide;   2-(4-(4-(benzo[d][1,3]dioxol-5-yl)butyl)phenyl)-N-hydroxyacetamide;   N-hydroxy-2-(4-(5-phenylpentyl)phenyl)acetamide;   N-hydroxy-2-(4-(4-(pyridin-4-yl)butyl)phenyl)acetamide;   N-hydroxy-2-(4-(4-(pyridin-3-yl)butyl)phenyl)acetamide;   N-hydroxy-2-(4-(4-(pyridin-2-yl)butyl)phenyl)acetamide;   N-hydroxy-2-(4-(3-phenylpropyl)phenyl)acetamide; and   N-hydroxy-4-(5-phenylpentyl)benzamide;   
       and pharmaceutically acceptable salts thereof. 
     
     
         36 . A compound selected from the group consisting of 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       and pharmaceutically acceptable salts thereof. 
     
     
         37 . A composition comprising a compound of  claim 35  or a pharmaceutically acceptable salt thereof. 
     
     
         38 . A composition comprising a compound of  claim 36  or a pharmaceutically acceptable salt thereof.