US2014024807A1PendingUtilityA1
Lenalidomide and Thalidomide Immunoassays
Est. expiryMar 12, 2030(~3.7 yrs left)· nominal 20-yr term from priority
C07D 401/14C07D 401/04C07K 16/44G01N 33/5308Y10S436/815G01N 33/9453
64
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Claims
Abstract
Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids.
Claims
exact text as granted — not AI-modified1 - 35 . (canceled)
36 . A compound of the formula:
wherein B is —C(═O)—CH 2 —, —C(═O)—NH—CH 2 —, —C(═O)—O—CH 2 — or —CH 2 — Y is an organic spacing group;
p is an integer from 0 to 1;
X is a terminal functional group capable of binding to said polyamine polymer;
37 . The compound of claim 36 wherein p is 0.
38 . The compound of claim 37 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
39 . The compound of claim 38 wherein X is
40 . The compound of claim 38 , wherein X is
and R 3 is hydrogen.
41 . The compound of claim 38 , wherein X is
and R 3 forms a reactive ester.
42 . The compound of claim 41 , wherein the ester formed is a lower alkyl ester, imidoester or amidoester.
43 . The compound of claim 36 , wherein p is 1.
44 . The compound of claim 43 wherein B is —C(═O)—CH 2 —.
45 . The compound of claim 43 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
46 . The compound of claim 45 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
47 . The compound of claim 46 , wherein Y is lower alkylene containing from 1 to 6 carbon atoms.
48 . The compound of claim 44 , wherein X is
and R 3 is as above.
49 . The compound of claim 48 wherein OR 3 forms a hydroxy succinimide ester.
50 . The compound of claim 46 , wherein Y is
wherein m and o are as above.
51 . The compound of claim 50 , wherein X is
and R 3 is as above.
52 . The compound of claim 51 wherein OR 3 forms a sulfo-N-hydroxy succinimide ester.
53 . A conjugate comprising a carrier conjugated with a ligand of the formula:
Wherein B is —C(═O)—CH 2 —, —C(═O)—NH—CH 2 —, —C(═O)—O—CH 2 — or —CH 2 — Y is an organic spacing group;
p is an integer from 0 to 1;
X is a terminal functional group capable of binding to a carrier;
54 . The conjugate of claim 53 , wherein the carrier is an immunogenic carrier which contains a polyamine polymer and X is a terminal functional group capable of binding to said polyamine polymer.
55 . The conjugate of claim 53 , wherein p is 0.
56 . The conjugate of claim 55 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
57 . The conjugate of claim 53 , wherein p is 1.
58 . The conjugate of claim 57 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
59 . The conjugate of claim 58 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
60 . The conjugate of claim 57 , wherein the carrier is an immunogenic carrier which contains a polyamine polymer and X is a terminal functional group capable of binding to said polyamine polymer
61 . The conjugate of claim 60 wherein Y is an alkylene containing from 1 to 6 carbon atoms.
62 . The conjugate of claim 61 , wherein X is
and R 3 is as above.
63 . The conjugate of claim 60 , wherein Y is
wherein m and o are as above.
64 . The conjugate of claim 63 , wherein X is
and R 3 is as above.
65 - 80 . (canceled)Join the waitlist — get patent alerts
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