Selective Poly-N-Substituted Glycine Antibiotics

Abstract

Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.

We claim: 
     
         1 . A poly-N-substituted glycine antibiotic compound of a formula 
       
         
           
           
               
               
           
         
         wherein A is selected from H and a terminal N-alkyl substituted glycine residue, where said alkyl substituent is selected from about C 4  to about C 20  linear, branched and cyclic alkyl moieties; n is an integer selected from 1-3; B is selected from NH 2 , one and two N-substituted glycine residues, said N-substituents independently selected from natural α-amino acid side chain moieties, isomers and carbon homologs thereof; X, Y and Z are independently selected from N-substituted glycine residues, said N-substituents independently selected from natural α-amino acid side chain moieties, isomers and carbon homologs thereof, and proline residues, at least one of said X, Y and Z residues is N Lys  and at least one said N-substituent is chiral, said compound of a formula