Compositions with metal chelator stabilized cationic ammonium compounds and a skin benefit agent

Abstract

Stabilized cationic ammonium compounds are described. The compounds are stabilized with metal chelators that impede the generation of nitrogen comprising groups from the cationic ammonium compounds.

1 . A composition comprising a cationic ammonium compound and a metal chelator, the metal chelator being one which impedes the generation of a nitrogen comprising group from the cationic ammonium compound within the composition, the composition comprising niacinamide, sunscreen, resorcinol, 12-hydroxystearic acid or a mixture thereof. 
     
     
         2 . A composition comprising a cationic ammonium compounds having the formula: 
       
         
           
           
               
               
           
         
       
       wherein q, t and v are each independently 0 or 1 with the proviso that the sum of q, t and v is equal to 1, each R is independently hydrogen, C 1-12  alkyl, C 1-12  hydroxy alkyl or 
       
         
           
           
               
               
           
         
       
       where q′, t′ and v′ are each independently 0 or 1 with the proviso that the sum of q′, t′ and v′ is equal to 1, each R 1  is independently a hydrogen, C 1-12  alkyl, or a C 1-12  hydroxy alkyl, each R 2  is independently hydrogen, C 1-3  alkyl, monosaccharyl, oligosaccharyl or polysaccharyl, each n is independently an integer from 1 to about 12, r is an integer from 0 to about 5, X −  is an anionic counterion, the cationic ammonium compound being stabilized with a metal chelator comprising amino groups and at least about 5 carboxylate groups, a metal chelator comprising amino groups and at least about 4 phosphonate groups or both. 
     
     
         3 . The composition according to  claim 2  wherein the anionic counterion is organic or inorganic. 
     
     
         4 . The composition according to  claim 2  wherein the metal chelator comprises at least about three amino groups and at least about five carboxylate groups, or at least about two amino groups and at least about four phosphonate groups or a mixture thereof. 
     
     
         5 . The composition according to  claim 2  wherein the cationic ammonium compound is a salt of hydroxypropyltri (C 1 -C 3  alkyl) ammonium mono-substituted-saccharide, salts of hydroxypropyltri (C 1 -C 3  alkyl) ammonium mono-substituted polyols, dihydroxypropyltri (C 1 -C 3  alkyl) ammonium salts, dihydroxypropyldi (C 1 -C 3  alkyl) mono(hydroxyethyl) ammonium salts, guar hydroxypropyl trimonium salts, 2,3-dihydroxypropyl tri(C 1 -C 3  alkyl or hydroxalkyl) ammonium salts or mixtures thereof. 
     
     
         6 . The composition according to  claim 2  wherein the cationic ammonium compound is 1,2-dihydroxypropyltrimonium chloride. 
     
     
         7 . A composition comprising: 
       
         
           
           
               
               
           
         
         (b) a cosmetically acceptable carrier; 
       
       wherein q, t and v are each independently 0 or 1 with the proviso that the sum of q, t and v is equal to 1, each R is independently hydrogen, C 1-12  alkyl, C 1-12  hydroxy alkyl or 
       
         
           
           
               
               
           
         
       
       where q′, t′ and v′ are each independently 0 or 1 with the proviso that the sum of q′, t′ and v′ is equal to 1, each R 1  is independently a hydrogen, C 1-12  alkyl, or a C 1-12  hydroxy alkyl, each R 2  is independently hydrogen, C 1-3  alkyl, monosaccharyl, oligosaccharyl or polysaccharyl, each n is independently an integer from 1 to about 12, r is an integer from 0 to about 5, X −  is an anionic counterion, the cationic ammonium compound being stabilized with a metal chelator comprising amino groups and at least about 5 carboxylate groups, a metal chelator comprising amino groups and at least about 4 phosphonate groups or both, the composition further comprising niacinamide, sunscreen, resorcinol, 12-hydroxystearic acid or a mixture thereof. 
     
     
         8 . The composition according to  claim 7  wherein the composition is topically applied to the body. 
     
     
         9 . The composition according to  claim 8  wherein the composition is a leave-on or rinse off composition. 
     
     
         10 . The composition according to  claim 9  wherein the composition is a moisturizing composition. 
     
     
         11 . The composition according to  claim 9  wherein the cationic ammonium compound is a salt of a hydroxypropyltri (C 1 -C 3  alkyl) ammonium mono-substituted saccharide, salts of hydroxypropyltri (C 1 -C 3  alkyl) ammonium mono-substituted polyols, dihydroxypropyltri (C 1 -C 3  alkyl) ammonium salts, dihydroxypropyldi (C 1 -C 3  alkyl) mono(hydroxyethyl) ammonium salts, guar hydroxypropyl trimonium salts, 2,3-dihydroxypropyl tri(C 1 -C 3  alkyl or hydroxalkyl) ammonium salts or mixtures thereof. 
     
     
         12 . The composition according to  claim 8  wherein the cationic ammonium compound is 1,2-dihydroxypropyltrimonium chloride. 
     
     
         13 . The composition according to  claim 9  wherein the composition comprises from about 0.02 to about 30% by weight cationic ammonium compound and from about 0.01 to about 5% by weight chelator. 
     
     
         14 . The composition according to  claim 9  wherein the metal chelator is diethylenetriaminepentacetic acid, triethylenetetraaminehexacetic acid, hexamethylenediaminetetramethylene phosphonic acid, a salt thereof or a mixture thereof. 
     
     
         15 . The composition according to  claim 9  wherein the metal chelator is diethylenetriaminepentacetic acid. 
     
     
         16 . The composition according to  claim 9  wherein the composition further comprises a humectant. 
     
     
         17 . The composition according to  claim 9  wherein the composition further comprises a substituted urea. 
     
     
         18 . The composition according to  claim 16  wherein the humectant is glycerine and the resorcinol is a 4-substituted resorcinol. 
     
     
         19 . The composition according to  claim 12  wherein the nitrogen comprising group is a trimonium group. 
     
     
         20 . A method for stabilizing a cationic ammonium compound comprising the steps of:
 a) contacting the cationic ammonium compound with a metal chelator; and   b) impeding the formation of a nitrogen comprising group, the cationic ammonium compound suitable for use with a sunscreen, niacinamide, 12-hydroxystearic acid, resorcinol or a mixture thereof.