Tablet Of Paracetamol Containing An Encapsulated Flavorant

Abstract

A medicament tablet containing paracetamol (acetaminophen) as the (or an) active ingredient, and an encapsulated flavorant. The tablet may be swallowed in tablet form or may be dissolved or dispersed in water to form a palatable drink.

What is claimed is: 
     
         1 . A medicament tablet comprising:
 paracetamol; and   an encapsulated flavorant.   
     
     
         2 . The tablet of  claim 1  comprising from 200-800 mg of paracetamol. 
     
     
         3 . The medicament tablet of  claim 1  further comprising a disintegration aid;
 wherein the tablet is suitable to be swallowed in tablet form, but also disperses or dissolves in water to produce a palatable drink. 
 
     
     
         4 . The medicament tablet of  claim 1  further comprising a URT aid selected from the group consisting of dextromethorphan, noscapine, ethyl morphine, theobromine, pholcodine, codeine, oxymetazoline, phenylephrine, pseudoephedrine, diphenhydramine, guaifenesin and ambroxol. 
     
     
         5 . The medicament tablet of  claim 1  further comprising another analgesic medicament selected from the group consisting of ibuprofen, flurbiprofen, buprenorphine, aspirin, codeine, celecoxib, diclofenac, ketoprofen, meloxicam, naproxen and rofecoxib. 
     
     
         6 . The tablet of  claim 3 , wherein the disintegration aid comprises a water-swellable polymer. 
     
     
         7 . The tablet of  claim 3  comprising from 20-200 mg of the disintegration aid. 
     
     
         8 . The tablet of  claim 6 , wherein the water-swellable polymer comprises crospovidone. 
     
     
         9 . A medicament tablet comprising:
 from 200-800 mg of paracetamol;   an encapsulated flavorant;   from 20-200 mg of a disintegration aid;   a URT aid selected from the group consisting of dextromethorphan, noscapine, ethyl morphine, theobromine, pholcodine, codeine, oxymetazoline, phenylephrine, pseudoephedrine, diphenhydramine, guaifenesin and ambroxol; and   another analgesic medicament selected from the group consisting of ibuprofen, flurbiprofen, buprenorphine, aspirin, codeine, celecoxib, diclofenac, ketoprofen, meloxicam, naproxen and rofecoxib;   wherein the tablet is suitable to be swallowed in tablet form, but also disperses or dissolves in water to produce a palatable drink.   
     
     
         10 . The tablet of  claim 9 , wherein the disintegration aid comprises a water-swellable polymer. 
     
     
         11 . The tablet of  claim 10 , wherein the water-swellable polymer comprises crospovidone. 
     
     
         12 . A medicament tablet comprising:
 paracetamol;   encapsulated flavorant;   disintegration aid;   binder;   pressing aid;   organic acid/salt flavorant; and   sweetening agent.   
     
     
         13 . The tablet of  claim 12 , wherein the tablet weight is within a weight range of from 700 to 1400 mg, and wherein the tablet has the following characteristics:
 its friability does not exceed 2% as determined by Ph Eur monograph method 2.9.7;   its hardness is in the range 8-26 kp as determined by Ph Eur monograph method 2.9.8;   it is palatable when taken as a tablet; and   it dissolves quickly in water to produce a palatable drink.   
     
     
         14 . The tablet of  claim 12 , wherein the components comprise the following weight ranges: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   Component 
                   Weight Range (mg) 
                 
                     
                     
                 
                     
                   paracetamol 
                   200-800  
                 
                     
                   encapsulated flavorant 
                   40-240 
                 
                     
                   disintegration aid 
                   20-200 
                 
                     
                   binder 
                   20-200 
                 
                     
                   pressing aid 
                   2-50 
                 
                     
                   organic acid/salt flavorant 
                   10-100 
                 
                     
                   sweetening agent 
                   10-80  
                 
                     
                     
                 
             
                
                
                
               
               
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         15 . The tablet of  claim 14 , wherein the tablet weight is within a weight range of from 700 to 1400 mg, and wherein the tablet has the following characteristics:
 its friability does not exceed 2% as determined by Ph Eur monograph method 2.9.7;   its hardness is in the range 8-26 kp as determined by Ph Eur monograph method 2.9.8;   it is palatable when taken as a tablet; and   it dissolves quickly in water to produce a palatable drink.   
     
     
         16 . A method of making the tablet of  claim 1  comprising compressing paracetamol and an encapsulated flavorant. 
     
     
         17 . The method according to  claim 16 , wherein the form of paracetamol and encapsulated flavorant is each individually selected from the group consisting of powder and granules. 
     
     
         18 . The method according to  claim 17  comprising a direct tabletting method. 
     
     
         19 . The method according to  claim 17 , wherein the method does not include a heating or warming step. 
     
     
         20 . The method according to  claim 17 , wherein the method does not include wet granulation. 
     
     
         21 . The method according to  claim 17 , wherein the method includes the addition of the encapsulated flavorant substantially at the stage when paracetamol is mixed with any other ingredients that may be present.