Annatto Extract Compositions Including Tocotrienols and Tocopherols and Methods of Use

Abstract

Compositions and methods of use of annatto extracts [350-450 Dalton molecular weight fraction] including tocotrienols and tocopherols with an appropriate spectrum. This spectrum includes but not limited to low alpha tocopherol, high delta- and gamma-tocols, and mixtures with other extracts [350-450 Dalton molecular weight fraction] like palm and rice and/or nutrients.

What is claimed is: 
     
         1 . A composition comprising a mixture of an annatto extract with tocotrienol and a natural extract, where the ratio of delta-tocotrienol to gamma-tocotrienol is from 1:25 to 25:1. 
     
     
         2 . The composition of  claim 1 , where the standardized tocopherols is from less than 50% to less than 1%. 
     
     
         3 . The composition of  claim 1 , where the natural extract is selected from the group consisting of soy, corn, rice bran, palm, olive, wheat germ, oat bran, sunflower seed, cottonseed, cranberry seed, and litchi seed. 
     
     
         4 . The composition of  claim 2 , where the tocopherol is alpha-T1. 
     
     
         5 . The composition of  claim 1 , where the annatto extract and the natural extract produce an appropriate spectrum. 
     
     
         6 . The composition of  claim 5 , where more than 50% of the tocotrienols are delta-T3 and gamma-T3. 
     
     
         7 . The composition of  claim 5 , where more than 50% of the tocotrienols are delta-T3. 
     
     
         8 . The composition of  claim 5 , where the composition is tocopherol-free. 
     
     
         9 . The composition of  claim 1 , where the tocotrienol is a C5 unsubstituted tocotrienol and the composition comprises more than 60% C5 unsubstituted tocotrienols, and less than 15% tocopherols. 
     
     
         10 . The composition of  claim 1 , wherein the tocotrienol activates PPARs. 
     
     
         11 . The composition of  claim 10 , where the tocotrienol further down regulates SREBP transcription factors. 
     
     
         12 . The composition of  claim 1 , where the tocotrienol decreases blood levels of triglyceride. 
     
     
         13 . The composition of  claim 12 , where the decrease in the blood level of the triglyceride has an effect selected from the group consisting of reversal of insulin resistance, metabolic syndrome, prediabetes, diabetes and diabetes-related cardiovascular disease. 
     
     
         14 . The composition of  claim 1 , where a tocotrienol treats a malady effecting the central nervous system. 
     
     
         15 . The composition of  claim 14 , where a tocotrienol treats a malady effecting the central nervous system, and the malady is selected from the group consisting of acute nerve damage, neural degenerative genetic disease, acute brain damage, brain trauma, chronic nerve damage, neural toxicity, chronic brain damage, Alzheimer's, Parkinson's, and Huntington's. 
     
     
         16 . The composition of  claim 1 , where the tocotrienol has a beneficial effect selected from the group consisting of lowers CRP, protects against inflammation, lowers cholesterol, decreases cardiovascular risk index, decreases metabolic risk index, decreases chemotactic bioactive materials, reduces osteoporosis, increases bone mineralization, enhances immune system, lowers lipids, and reverses insulin resistance