US2014039022A1PendingUtilityA1

Manufacture, compositions and uses of coagulation factor viia modulator

Assignee: PHARMACYCLICS INCPriority: Oct 16, 2007Filed: Oct 8, 2013Published: Feb 6, 2014
Est. expiryOct 16, 2027(~1.2 yrs left)· nominal 20-yr term from priority
A61K 41/00A61K 31/4184C07D 235/18A61P 43/00A61P 35/00A61P 35/04A61K 45/06C07D 209/00A61P 7/02A61P 35/02C07D 235/12A61K 31/4164
66
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Claims

Abstract

Treatment of cancer and thromboembolic disorders using inhibitors of Factor VIIa are disclosed herein using a compound of Formula I:

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A solution comprising:
 a) a compound of Formula I or a salt thereof:   
       
         
           
           
               
               
           
         
       
       and
 b) a thrombin modulator; 
 
       wherein the compound of Formula I and the thrombin modulator are in solution. 
     
     
         2 . A composition comprising:
 a) a compound of Formula I or a salt thereof:   
       
         
           
           
               
               
           
         
       
       and
 b) an amino acid buffer. 
 
     
     
         3 . A combined dosage comprising:
 a) a compound of Formula I or a salt thereof:   
       
         
           
           
               
               
           
         
       
       and
 b) an additional therapeutic agent; 
 
       wherein the compound of Formula I and the additional therapeutic agent are in a combined dosage form. 
     
     
         4 . A composition comprising:
 a) a compound of Formula I or a salt thereof:   
       
         
           
           
               
               
           
         
         b) a pH adjusting agent; 
       
       wherein the pH of the composition is between 7 and 9. 
     
     
         5 . A kit comprising, a container comprising:
 a) a compound of Formula I or a salt thereof:   
       
         
           
           
               
               
           
         
       
       and
 b) an additional therapeutic agent; and 
 c) a buffer and/or diluent.

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