Nutritional composition

Abstract

A nutritional composition is provided which has an effective prophylactic and/or improving effect for various symptoms of muscle mass decrease, decreased basal metabolism, low body temperature, suppression of obesity, suppression of visceral fat accumulation, hyperglycemia, hyperlipidemia and the like in elderly people. The nutritional composition can include n-3 fatty acid and one or more of free lysine, dipeptides containing lysine, and lysine salts, wherein the content of free lysine, dipeptides containing lysine, and/or lysine salts is 0.1 g-10.0 g per 100 kcal of the composition, and the content of the total amount of n-3 fatty acid is 0.17 g-5.00 g per 100 kcal of the composition.

1 . A nutritional composition comprising:
 i) n-3 fatty acid, and   ii) an ingredient selected from the group consisting of free lysine, dipeptides containing lysine and lysine salts, and combinations thereof;   wherein the ingredient is present in the composition in an amount of 0.1 g-10.0 g per 100 kcal of the composition, and   wherein the n-3 fatty acid is present in the composition in an amount of 0.17 g-5.00 g per 100 kcal of the composition.   
     
     
         2 . The nutritional composition according to  claim 1 , further comprising a branched chain amino acid selected from the group consisting of valine, leucine, isoleucine, and combinations thereof. 
     
     
         3 . The nutritional composition according to  claim 2 , wherein the branched chain amino acid is present in the composition in an amount of 1.0 g-20 g per 100 kcal of the composition. 
     
     
         4 . The nutritional composition according to  claim 2 , wherein the branched chain amino acid in a free form is present in the composition in an amount of 0.1 g-15 g per 100 kcal of the composition. 
     
     
         5 . The nutritional composition according to  claim 1 , wherein the n-3 fatty acid is selected from the group consisting of eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, and combinations thereof. 
     
     
         6 . The nutritional composition according to  claim 5 , comprising 10 mg-3000 mg of eicosapentaenoic acid per 100 kcal of the composition. 
     
     
         7 . The nutritional composition according to  claim 1 , further comprising a vitamin selected from the group consisting of:
 0.2 mg-20.0 mg of vitamin B1 per 100 kcal of the composition,   0.25 mg-20.0 mg of vitamin B2 per 100 kcal of the composition,   0.3 mg-20.0 mg of vitamin B6 per 100 kcal of the composition,   0.3 μg-20.0 μg of vitamin B12 per 100 kcal of the composition, and   combinations thereof.   
     
     
         8 . The nutritional composition according to  claim 1 , further comprising a vitamin selected from the group consisting of:
 50 μg retinol equivalents-2500 μg retinol equivalents of vitamin A per 100 kcal of the composition,   10 mg-700 mg of vitamin C per 100 kcal of the composition,   1 mg-50 mg of vitamin E based on α-tocopherol per 100 kcal of the composition, and   combinations thereof.   
     
     
         9 . The nutritional composition according to  claim 1 , further comprising 1 mg-50 mg of zinc per 100 kcal of the composition and/or 1.0 μg-50.0 μg of selenium per 100 kcal of the composition. 
     
     
         10 . The nutritional composition according to  claim 1 , comprising medium chain fatty acid oil in an amount of 10 wt %-65 wt % relative to the total amount of lipid. 
     
     
         11 . The nutritional composition according to  claim 1 , which is capable of increasing muscle mass and/or suppressing a decrease in the muscle mass. 
     
     
         12 . The nutritional composition according to  claim 1 , which is capable of decreasing visceral fat or increasing energy consumption. 
     
     
         13 . The nutritional composition according to  claim 1 , which is capable of an effect selected from the group consisting of
 i) prophylaxis and/or improvement of muscle weakness symptom,   ii) promotion of rehabilitation effect for muscle recovery,   iii) prophylaxis and/or improvement of dyslipidemia associated with visceral fat increase,   iv) prophylaxis and/or improvement of hyperglycemia associated with visceral fat increase,   v) prophylaxis and/or improvement of fatty liver associated with visceral fat increase,   vi) prophylaxis and/or improvement of deteriorated liver function associated with visceral fat increase,   vii) prophylaxis and/or improvement of decrease in basal energy consumption,   viii) prophylaxis and/or improvement of decrease in basal body temperature,   ix) prophylaxis and/or improvement of muscle mass decrease unaccompanied by an increase in inflammatory cytokine,   x) improvement of low nutrient condition,   xi) improvement of deterioration in locomotorium, xii) prophylaxis and/or improvement of locomotive syndrome,   xiii) prevention of falling,   ixv) increase of muscle mass in sports, and   xv) combinations thereof.   
     
     
         14 . A method for increasing muscle mass and/or suppressing a decrease in muscle mass, comprising administering an effective amount of the composition according to  claim 1 . 
     
     
         15 . A method for decreasing visceral fat or increasing energy consumption, comprising administering an effective amount of the composition according to  claim 1 . 
     
     
         16 . A method for treating a condition comprising administering an effective amount of the composition according to  claim 1 , wherein said condition is selected from the group consisting of
 i) the prophylaxis and/or improvement of muscle weakness symptom,   ii) the promotion of rehabilitation effect for muscle recovery,   iii) the prophylaxis and/or improvement of dyslipidemia associated with visceral fat increase,   iv) the prophylaxis and/or improvement of hyperglycemia associated with visceral fat increase,   v) the prophylaxis and/or improvement of fatty liver associated with visceral fat increase,   vi) the prophylaxis and/or improvement of deteriorated liver function associated with visceral fat increase,   vii) the prophylaxis and/or improvement of decrease of basal energy consumption,   viii) the prophylaxis and/or improvement of decrease of basal body temperature,   ix) the prophylaxis and/or improvement of muscle mass decrease unaccompanied by an increase in inflammatory cytokine,   x) the improvement of low nutrient condition, xi) the improvement of deterioration in locomotorium,   xii) the prophylaxis and/or improvement of locomotive syndrome,   xiii) prevention of falling,   ixv) a method for increasing muscle mass in sports, and   xv) combinations thereof.   
     
     
         17 . A method for producing an agent for increasing muscle mass and/or suppressing a decrease in muscle mass comprising formulating a composition according to  claim 1 . 
     
     
         18 . A method for producing an agent for decreasing visceral fat or increasing energy consumption comprising formulating a composition according to  claim 1 . 
     
     
         19 . A method for producing an agent for treating a condition comprising formulating a composition according to  claim 1 , wherein the condition is selected from the group consisting of:
 i) the prophylaxis and/or improvement of muscle weakness symptom,   ii) promoting a rehabilitation effect for muscle recovery,   iii) the prophylaxis and/or improvement of dyslipidemia associated with visceral fat increase,   iv) the prophylaxis and/or improvement of hyperglycemia associated with visceral fat increase,   v) the prophylaxis and/or improvement of fatty liver associated with visceral fat increase,   vi) the prophylaxis and/or improvement of deteriorated liver function associated with visceral fat increase,   vii) the prophylaxis and/or improvement of decrease of basal energy consumption,   viii) the prophylaxis and/or improvement of decrease of basal body temperature,   ix) the prophylaxis and/or improvement of muscle mass decrease unaccompanied by an increase in inflammatory cytokine,   x) improvement of low nutrient condition,   xi) improving deterioration in locomotorium, xii) the prophylaxis and/or improvement of locomotive syndrome,   ixv) prevention of falling,   xv) increasing muscle mass in sports, and   xvi) combinations thereof.