Light calibration device, biological detection calibration system and operating method thereof

Abstract

A biological detection calibration system includes a biological detection device and a light calibration device. The biological detection device is for detecting a biological sample and includes a light source and a controller electrically connected thereto to control the light source to emit a light. The light calibration device includes a carrier, disposed at a detecting position of the biological sample in the biological detection device to receive the light emitted from the light source, and a calibration sample, disposed on the carrier and including a light detector. The light detector is for detecting intensity of the light and transmitting intensity information to the controller. The controller reads the intensity information of the light and compares the intensity information with a predetermined value to modify driving energy of the light source so that the intensity of the light detected by the light detector is not less than the predetermined value.

What is claimed is: 
     
         1 . A light calibration device, adapted for a biological detection device, which comprises a light source and a controller for detecting a biological sample, the light calibration device comprising:
 a carrier disposed at a detecting position of the biological sample in the biological detection device to receive a light emitted from the light source; and   a calibration sample disposed on the carrier and comprising a light detector adapted for detecting an intensity of the light emitted from the light source to the carrier, and the calibration sample being adapted for transmitting intensity information of the light detected by the light detector to the controller.   
     
     
         2 . The light calibration device according to  claim 1 , wherein the carrier is a blank micro titer plate and comprises at least one recess, and the light detector is disposed at a position corresponding to the at least one recess. 
     
     
         3 . The light calibration device according to  claim 1 , wherein the calibration sample further comprises a circuit board electrically connected to the light detector. 
     
     
         4 . The light calibration device according to  claim 3 , wherein the circuit board further comprises a wireless transmission unit and correspondingly the controller comprises a wireless reception unit, and the intensity information of the light detected by the light detector is transmitted to the wireless reception unit of the controller via the wireless transmission unit. 
     
     
         5 . The light calibration device according to  claim 3 , wherein the circuit board is disposed on the carrier and the light detector is disposed to face the at least one recess to detect the intensity of the light emitted from the light source to the recess. 
     
     
         6 . The light calibration device according to  claim 3 , wherein the circuit board together with the light detector is disposed in the at least one recess of the carrier. 
     
     
         7 . A biological detection calibration system, comprising:
 a biological detection device detecting a biological sample and comprising:
 a light source emitting a light to the biological sample that is to be detected; 
 a controller electrically connected to the light source to drive and control the light source to emit the light; 
   a light calibration device, comprising:
 a carrier disposed at a detecting position of the biological sample in the biological detection device to receive the light emitted from the light source; and 
 a calibration sample disposed on the carrier and comprising a light detector adapted for detecting the intensity of the light emitted to the carrier and transmitting intensity information to the controller; 
   wherein the controller is adapted for reading the intensity information of the light detected by the light detector and comparing the intensity information with a predetermined value to adjust driving energy of the light source, so that the intensity of the light detected by the light detector is not less than the predetermined value.   
     
     
         8 . The biological detection calibration system according to  claim 7 , wherein the carrier is a blank micro titer plate and comprises at least one recess, and the light detector is disposed at a position corresponding to the at least one recess. 
     
     
         9 . The biological detection calibration system according to  claim 7 , wherein the calibration sample further comprises a circuit board electrically connected to the light detector. 
     
     
         10 . The biological detection calibration system according to  claim 9 , wherein the circuit board further comprises a wireless transmission unit and correspondingly the controller comprises a wireless reception unit, and the intensity information of the light detected by the light detector is transmitted to the wireless reception unit of the controller via the wireless transmission unit. 
     
     
         11 . The biological detection calibration system according to  claim 9 , wherein the circuit board is disposed on the carrier and the light detector is disposed to face the at least one recess to detect the intensity of the light emitted from the light source to the recess. 
     
     
         12 . The biological detection calibration system according to  claim 9 , wherein the circuit board together with the light detector is disposed in the at least one recess of the carrier. 
     
     
         13 . The biological detection calibration system according to  claim 7 , wherein the biological detection device further comprises an optical device guiding the light of the light source to a position to irradiate the carrier. 
     
     
         14 . The biological detection calibration system according to  claim 13 , wherein the optical device is a mirror or an optical fiber. 
     
     
         15 . The biological detection calibration system according to  claim 14 , wherein the biological detection device further comprises a microscope module and an image capturing module, wherein the microscope module is disposed at a side of the optical device opposite to the carrier for receiving a reaction of the biological sample to which the light is emitted, and the image capturing module captures an image of the reaction. 
     
     
         16 . The biological detection calibration system according to  claim 7 , wherein the biological detection device further comprises a display module electrically connected to the controller. 
     
     
         17 . The biological detection calibration system according to  claim 7 , wherein the biological detection device further comprises a control interface electrically connected to the controller for performing a function operation or parameter setting on the controller. 
     
     
         18 . An operating method of a biological detection calibration system, adapted for a biological detection device which comprises a light source for emitting a light to detect a biological sample, the operating method comprising:
 detecting whether a light calibration device exists on the biological detection device, wherein the light calibration device comprises a carrier and a calibration sample disposed on the carrier, and the calibration sample comprises a light detector;   reading an intensity of the light detected by the light detector if the light calibration device exists;   determining whether the intensity of the light detected by the light detector is less than a predetermined value; and   enhancing a driving voltage of the light source, such that the intensity of the light detected by the light detector reaches the predetermined value if the intensity of the light detected by the light detector is less than the predetermined value.   
     
     
         19 . The operating method according to  claim 18 , further comprising:
 determining whether the intensity of the light detected by the light detector reaches the predetermined value; and   sending a warning signal if the intensity of the light detected by the light detector does not reach the predetermined value after the driving voltage of the light source is enhanced.   
     
     
         20 . The operating method according to  claim 18 , wherein whether the light calibration device exists is determined by whether the light detector detects the light emitted from the light source. 
     
     
         21 . The operating method according to  claim 18 , wherein a normal detection mode is performed if the light calibration device does not exist. 
     
     
         22 . The operating method according to  claim 18 , wherein the calibration is completed if the intensity of the light detected by the light detector is not less than the predetermined value. 
     
     
         23 . The operating method according to  claim 18 , wherein the biological detection device further comprises a controller adapted for driving and controlling the light source to emit the light and comparing the intensity of the light detected by the light detector with the predetermined value. 
     
     
         24 . The operating method according to  claim 23 , wherein the calibration sample further comprises a circuit board electrically connected to the light detector. 
     
     
         25 . The operating method according to  claim 24 , wherein the circuit board further comprises a wireless transmission unit and the controller comprises a wireless reception unit, and the intensity information of the light detected by the light detector is transmitted to the wireless reception unit of the controller via the wireless transmission unit. 
     
     
         26 . The operating method according to  claim 23 , wherein the biological detection device further comprises a display module electrically connected to the controller.