Methods of decreasing sebum production in the skin

Abstract

Provided herein are methods of using gaseous nitric oxide and/or at least one nitric oxide source to or decrease sebum production in the skin of a subject. In some embodiments, the nitric oxide source includes small molecule and/or macromolecular NO-releasing compounds,

That which we claim is: 
     
         1 . A method of decreasing sebum production in skin of a subject comprising applying nitric oxide and/or at least one nitric oxide source to the skin in an amount sufficient to decrease sebum production. 
     
     
         2 . The method of  claim 1 , wherein the sebum production in the skin is decreased by applying gaseous nitric oxide to the skin of the subject. 
     
     
         3 . The method of  claim 1 , wherein the sebum production in the skin is decreased by applying at least one nitric oxide source to the skin of the subject. 
     
     
         4 . The method of  claim 3 , wherein the at least one nitric oxide source comprises a nitric oxide (NO)-releasing compound. 
     
     
         5 . The method of  claim 4 , wherein the NO-releasing compound comprises a small molecule NO-releasing compound. 
     
     
         6 . The method of  claim 4 , wherein the NO-releasing compound comprises a macromolecular NO-releasing compound. 
     
     
         7 . The method of  claim 6 , wherein the macromolecular NO-releasing compound comprises N-diazeniumdiolate-functionalized macromolecules. 
     
     
         8 . The method of  claim 7 , wherein the N-diazeniumdiolate-functionalized macromolecules comprise N-diazeniumdiolate co-condensed polysiloxane macromolecules. 
     
     
         9 . The method of  claim 6 , wherein the macromolecular NO-releasing compound comprises nitrosothiol-functionalized macromolecules. 
     
     
         10 . The method of  claim 4 , wherein the NO-releasing compound is present in a pharmaceutically acceptable composition. 
     
     
         11 . The method of  claim 10 , wherein the pharmaceutically acceptable composition comprises at least one other therapeutic agent. 
     
     
         12 . The method of  claim 1 , wherein the nitric oxide is applied at a concentration that is toxic production sites, 
     
     
         13 . The method of  claim 1 , wherein the nitric oxide is applied at a concentration that is not toxic to sebum production sites. 
     
     
         14 . The method of  claim 1 , wherein the nitric oxide is applied at a concentration that is preferentially toxic to sebum production sites over keratinocytes. 
     
     
         15 . A method of decreasing sebum production in skin of a subject comprising systemically applying nitric oxide and/or at least one nitric oxide source to the subject in an amount sufficient to decrease sebum production in the skin.