Cancer treatment using viruses and camptothecins

Abstract

Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. The treatment can also include administration of a monoclonal antibody against epidermal growth factor receptor, for example cetuximab.

What is claimed is: 
     
         1 . A method of treating a mammalian subject having a neoplasm, comprising administering to the subject a Newcastle disease_virus and a camptothecin compound in a combined amount effective to treat the subject. 
     
     
         2 . The method of  claim 1 , further comprising administering to the subject a monoclonal antibody against epidermal growth factor receptor in an amount effective, in combination with the virus and the camptothecin compound, to treat the subject. 
     
     
         3 . The method of  claim 2 , wherein the monoclonal antibody is cetuximab. 
     
     
         4 . The method of  claim 1 , wherein the virus is replication-competent. 
     
     
         5 . The method of  claim 1 , wherein the virus is a mesogenic strain of Newcastle disease virus 
     
     
         6 . The method of  claim 1 , wherein the virus is administered intravenously. 
     
     
         7 . The method of  claim 1  wherein the camptothecin compound is selected from the group consisting of topotecan, 9-aminocamptothecin, exatecan, karenitecin, rubitecan, lurtotecan, and a homocamptothecin. 
     
     
         8 . The method of  claim 1 , wherein the camptothecin compound is irinotecan. 
     
     
         9 . The method of  claim 1 , wherein the camptothecin compound and the virus are administered to the subject within a single twenty-four hour period. 
     
     
         10 . The method of  claim 1 , wherein the camptothecin compound is administered from twenty-four hours to one month before administration of the virus. 
     
     
         11 . The method of  claim 10 , wherein the camptothecin compound is administered from twenty-four hours to one week before administration of the virus. 
     
     
         12 . The method of  claim 1 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one month after administration of the virus. 
     
     
         13 . The method of  claim 12 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one week after administration of the virus.