US2014065216A1PendingUtilityA1

Bioactive Dose Having Containing a Material for Modulating pH of a Bodily Fluid to Help or Hinder

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Assignee: FUISZ RICHARD CPriority: Jun 28, 2010Filed: Sep 3, 2013Published: Mar 6, 2014
Est. expiryJun 28, 2030(~4 yrs left)· nominal 20-yr term from priority
Inventors:Richard C. FuiszJoseph M. Fuisz
A61K 36/3482A61K 31/465A61K 36/81A61K 9/2806
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Claims

Abstract

A bioactive dose for delivering a bioactive agent to a mammal, includes a solid bioactive dosage unit containing at least one bioactive agent and a rapid release coating provided on at least one outer surface of the solid bioactive dosage unit, the rapid release coating containing a material having a property of rapidly modulating a pH of bodily fluids in which the material comes in contact in a direction towards an ideal absorptive pH or towards an ideal pH to hinder absorption of the at least one bioactive agent given the pKa that least at one bioactive agent. A modified liquid that is administered prior to, contemporaneous with, or following the delivery of a bioactive agent is also described. The liquid includes a pH modifier selected to control the pH of the liquid to a predetermined range so that the modified liquid rapidly modulates the pH of bodily fluids to enhance or hinder absorption of the bioactive agent.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . A bioactive dose for delivering a bioactive agent to a mammal, comprising a solid bioactive dosage unit containing a bioactive agent provided in a pouch and a rapid release coating provided on substantially all of the pouch material or in substantially all of the pouch material, the rapid release coating comprising a material having a property of moving a pH of bodily fluids with which the material comes in contact in a direction towards an ideal absorptive pH of the at least one bioactive agent given the pKa of that the bioactive agent. 
     
     
         2 . The bioactive dose according to  claim 1 , wherein the bioactive agent comprises a botanical. 
     
     
         3 . The bioactive dose according to  claim 1 , wherein material in the rapid release coating is acidic. 
     
     
         4 . The bioactive dose according to  claim 1 , wherein material in the rapid release coating is basic. 
     
     
         5 . The bioactive dose according to  claim 1 , wherein the rapid release coating dissolves in 30 seconds or less. 
     
     
         6 . The bioactive dose according to  claim 1 , wherein the rapid release coating dissolves in 20 seconds or less. 
     
     
         7 . The bioactive dose according to  claim 1 , wherein the rapid release coating dissolves in 10 seconds or less. 
     
     
         8 . The bioactive dose according to  claim 1 , wherein the rapid release coating is provided on the pouch material. 
     
     
         9 . The bioactive dose according to  claim 1 , wherein the rapid release coating is provided in the pouch material. 
     
     
         10 . A bioactive dose for delivering a bioactive agent to a mammal, comprising a solid bioactive dosage unit containing at least one bioactive agent, the at least one bioactive agent not categorized as a drug by the U.S. Food and Drug Administration, and a rapid release coating provided on at least one outer surface of the solid bioactive dosage unit, the rapid release coating containing a material having a property of moving a pH of bodily fluids with which the material comes in contact in a direction towards an ideal absorptive pH of the at least one bioactive agent given the pKa of that at least one bioactive agent. 
     
     
         11 . The bioactive dose according to  claim 10 , wherein the at least one bioactive agent comprises a botanical. 
     
     
         12 . The bioactive dose according to  claim 10 , wherein the rapid release coating is provided on an outermost surface of the bioactive dose. 
     
     
         13 . The bioactive dose according to  claim 10 , further comprising an outer enteric coating provided on an outer surface of the rapid release coating. 
     
     
         14 . The bioactive dose according to  claim 10 , wherein material in the rapid release coating is acidic. 
     
     
         15 . The bioactive dose according to  claim 10 , wherein material in the rapid release coating is basic. 
     
     
         16 . The bioactive dose according to  claim 10 , wherein the rapid release coating dissolves in 30 seconds or less. 
     
     
         17 . The bioactive dose according to  claim 10 , wherein the rapid release coating dissolves in 20 seconds or less. 
     
     
         18 . The bioactive dose according to  claim 10 , wherein the rapid release coating dissolves in 10 seconds or less.

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