Pharmacological preparation for topical use containing npalmitoyl-vanillamide

Abstract

The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.

1 . A method for treating or ameliorating hyperalgesia caused by inflammatory or neuropathic conditions in a mammal comprising administering to the mammal a composition comprising from about 0.05% to about 5% w/w of N-palmitoyl-vanillamide. 
     
     
         2 . The method of  claim 1 , wherein the mammal is human. 
     
     
         3 . The method of  claim 1 , wherein the mammal is a cat or a dog. 
     
     
         4 . The method of  claim 1 , wherein said inflammatory or neuropathic conditions are selected from the group consisting of post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glossopharyngeal neuralgia, headache, uremic neuralgia, diabetic neuralgia, neuropathic itch, neurogenic itch, uremic itch, vulvodynia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders, psoriasis-associated pruritus and pain, atopic dermatitis, itching skin diseases, muscular pain, pain of a tendon, osteoarthritis-associated pain, painful eye diseases, and inflammatory pathologies of the oral cavity. 
     
     
         5 . The method of  claim 4 , wherein the inflammatory pathologies of the oral cavity are selected from the group consisting of gingivitis, periodontitis, stomatitis, post implantation pain, and burning mouth syndrome. 
     
     
         6 . The method of  claim 4 , wherein the inflammatory pathologies of the oral cavity are selected from the group consisting of: canine and feline gingivitis, periodontitis, gingivostomatitis, and feline resorptive lesions (FORL). 
     
     
         7 . The method of  claim 1 , wherein said composition is in the form of a topical composition. 
     
     
         8 . The method of  claim 7 , wherein said topical composition is a cream, gel, lotion, drops for otological application, patch, eyewash, mouthwash, or suppository. 
     
     
         9 . The method of  claim 7 , wherein the composition comprises one or more additional active principles selected from the group consisting of: adelmidrol, trans-traumatic acid, menthol, hyaluronic acid or its salts, Vitamin A, and any combination thereof. 
     
     
         10 . A method for treating or ameliorating hyperalgesia caused by inflammatory or neuropathic conditions in a mammal comprising administering to the mammal a composition comprising N-palmitoyl-vanillamide and one or more additional active principles selected from the group consisting of adelmidrol, trans-traumatic acid, menthol, hyaluronic acid or its salts, Vitamin A, and any combination thereof. 
     
     
         11 . The method of  claim 10 , wherein the mammal is human. 
     
     
         12 . The method of  claim 10 , wherein the mammal is a cat or a dog. 
     
     
         13 . The method of  claim 10 , wherein said inflammatory or neuropathic conditions are selected from the group consisting of post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glossopharyngeal neuralgia, headache, uremic neuralgia, diabetic neuralgia, neuropathic itch, neurogenic itch, uremic itch, vulvodynia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders, psoriasis-associated pruritus and pain, atopic dermatitis, itching skin diseases, muscular pain, pain of a tendon, osteoarthritis-associated pain, painful eye diseases, and inflammatory pathologies of the oral cavity. 
     
     
         14 . The method of  claim 13 , wherein the inflammatory pathologies of the oral cavity are selected from the group consisting of gingivitis, periodontitis, stomatitis, post implantation pain, and burning mouth syndrome. 
     
     
         15 . The method of  claim 13 , wherein wherein the inflammatory pathologies of the oral cavity are selected from the group consisting of: canine and feline gingivitis, periodontitis, gingivostomatitis, and feline resorptive lesions (FORL). 
     
     
         16 . The method of  claim 10 , wherein said composition is in the form of a topical composition. 
     
     
         17 . The method of  claim 16 , wherein the composition comprises from about 0.05% to about 5% w/w of N-palmitoyl-vanillamide. 
     
     
         18 . The method of  claim 16 , wherein said topical composition is a cream, gel, lotion, drops for otological application, patch, eyewash, mouthwash, or suppository.