Therapeutic delivery system

Abstract

Therapeutic delivery systems are provided which, in a first embodiment, contain a plurality of multiphase capsules in which first and second therapeutic agents are contained in separate phases within said multiphase capsules, and are disposed to deliver said first and therapeutic agents by at least two different delivery mechanisms.

1 . A nasal dilator comprising:
 an elongated, flexible substrate;   a resilient layer including at least three coplanar resilient members bonded to said elongated, flexible substrate to provide an expanding force to a nasal wall tissue when said dilator is adhesively attached to a wearer's nose, said resilient members disposed longitudinally along said elongated, flexible substrate in substantially parallel alignment with one another; and   a pressure sensitive adhesive layer disposed on a bottom surface of said dilator.   
     
     
         2 . The nasal dilator of  claim 1  wherein said at least three resilient members are connected together by a plurality of transverse resilient members to form a scrim. 
     
     
         3 . The nasal dilator of  claim 1  wherein each of said at least three resilient members comprise a pair of longitudinal edges which are substantially parallel with one another and also parallel with a pair of longitudinal edge portions of said elongated, flexible substrate. 
     
     
         4 . The nasal dilator of  claim 1  wherein said at least three resilient members each comprise the same width and length. 
     
     
         5 . A nasal dilator comprising:
 an elongated, flexible substrate having a central longitudinal axis, a longitudinal length and transverse ends, said elongated, flexible substrate being substantially breathable;   a resilient layer comprising at least three resilient members bonded to said elongated, flexible substrate to provide a gentle expanding force to a nasal wall tissue when said dilator is adhesively attached to a wearer's nose, said at least three resilient members including a first, second and third resilient member disposed in a direction which is substantially parallel to said central longitudinal axis; and   a pressure sensitive adhesive layer disposed on the bottom surface of said dilator.   
     
     
         6 . A nasal dilator for substantially preventing a nasal wall tissue of a nose from drawing in during breathing, comprising
 an elongated, flexible substrate having a peripheral edge, a pair of longitudinal sides, a pair of transverse ends, and top and bottom surfaces thereon;   a pressure sensitive adhesive layer disposed on said bottom surface of said elongated, flexible substrate;   a resilient layer comprising at least three resilient members disposed in the same plane and bonded to said elongated, flexible substrate to provide a gentle expanding force to said nasal wall tissue when said dilator is adhesively attached to said nose, said resilient members disposed longitudinally along said elongated, flexible substrate in substantially parallel alignment with one another, said at least three resilient members having a middle resilient member having a central longitudinal axis which is aligned with the central longitudinal axis of said elongated, flexible substrate; and   a pressure sensitive adhesive layer disposed on a bottom of said dilator.   
     
     
         7 . The nasal dilator of  claim 6  wherein said at least three resilient members comprise a pair of resilient members on either side of a middle resilient member, said pair of resilient members having a central longitudinal axis which is disposed in parallel with a central longitudinal axis of said middle resilient member. 
     
     
         8 . The nasal dilator of  claim 6  wherein said at least three resilient members are connected together by a plurality of transverse resilient members to form a scrim. 
     
     
         9 . A nasal dilator for substantially preventing a nasal wall tissue of a nose from drawing in during breathing, comprising
 an elongated, flexible substrate having a peripheral edge, a pair of longitudinal sides, a pair of transverse ends, and top and bottom surfaces thereon;   a pressure sensitive adhesive layer disposed on said bottom surface of said elongated, flexible substrate;   a resilient layer comprising three resilient portions, said resilient layer bonded to said elongated, flexible substrate to provide a gentle expanding force to said nasal wall tissue when said dilator is adhesively attached to said nose; a first of said three resilient portions disposed longitudinally along said elongated, flexible substrate from a first of said pair of transverse ends to a second of said pair of transverse ends, a second of said three resilient portions disposed laterally on said elongated, flexible substrate from said first resilient portion and also disposed longitudinally along said elongated, flexible substrate from a first of said pair of transverse ends to a second of said pair of transverse ends, and a third of said three resilient portions disposed between said first and second resilient portions.   
     
     
         10 . The nasal dilator of  claim 9 , wherein said first, second and third second resilient portions are about the same size and shape. 
     
     
         11 . The nasal dilator of  claim 9 , wherein said first, second and third second resilient portions are made of a resin. 
     
     
         12 . The nasal dilator of  claim 9 , wherein said first, second and third second resilient portions are spaced from one another across the width of said elongated, flexible substrate. 
     
     
         13 . The nasal dilator of  claim 9 , wherein said first, second and third second resilient portions comprise one or more spring strips. 
     
     
         14 . A nasal dilator for substantially preventing a nasal wall tissue of a nose from drawing in during breathing, comprising
 an elongated, flexible substrate having a peripheral edge, a pair of longitudinal sides, a pair of transverse ends, and top and bottom surfaces thereon;   a pressure sensitive adhesive layer disposed on said bottom surface of said elongated, flexible substrate;   a resilient layer comprising three co-planar resilient members, said resilient layer bonded to said elongated, flexible substrate to provide a gentle expanding force to said nasal wall tissue when said dilator is adhesively attached to said nose; a first of said three resilient members disposed longitudinally along said elongated, flexible substrate from a first of said pair of transverse ends to a second of said pair of transverse ends, a second of said three resilient members disposed laterally on said elongated, flexible substrate from said first resilient member and also disposed longitudinally along said elongated, flexible substrate from a first of said pair of transverse ends to a second of said pair of transverse ends, and a third of said three resilient members disposed between said first and second resilient members and laterally spaced therefrom.   
     
     
         15 . The nasal dilator of  claim 14 , wherein said third resilient member is laterally spaced about the same distance from said first and second resilient portions. 
     
     
         16 . The nasal dilator of  claim 14 , wherein said third resilient member is also disposed longitudinally along said elongated, flexible substrate from a first of said pair of transverse ends to a second of said pair of transverse ends. 
     
     
         17 . The nasal dilator of  claim 14 , further comprising a transdermal medicinal component. 
     
     
         18 . The nasal dilator of  claim 14 , further comprising a fourth resilient portion. 
     
     
         19 . The nasal dilator of  claim 15 , further comprising a fifth resilient portion.