Bradykinin b1 antagonists

Abstract

The invention relates to compounds of formula (I) wherein R 1 , R 1a , R 1b , R 2 , R 3 and X, X 1 , X 2 , X 3 have the meaning as cited in the description and the claims. Said compounds are useful as Bradykinin B1 antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.

1 . A compound of formula (I) 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt, prodrug or metabolite thereof, wherein 
         X is phenyl or a 5- or 6-membered aromatic heterocycle, wherein X is substituted with R 4  and is optionally substituted with one or more R 5 , which are the same or different; 
         R 4  and R 5  are independently selected from the group consisting of halogen, CN, C(O)OR 6 , OR 6 , C(O)N(R 6 R 6a ), S(O) 2 N(R 6 R 6a ), S(O)N(R 6 R 6a .), S(O) 2 R 6 , N(R 6 )S(O) 2 N(R 6a R 6b ), SR 6 , N(R 6 R 6a ), OC(O)R 6 , N(R 6 )C(O)R 6a , N(R 6 )S(O) 2 R 6a , N(R 6 )S(O)R 6a , N(R 6 )C(O)N(R 6a R 6b ), N(R 6 )C(O)OR 6a , OC(O)N(R 6 R 6a ), C(O)R 6 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and T, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 7 , which are the same or different; 
         Optionally, R 4  and R 5  or two adjacent R 5  are joined together with the atoms to which they are attached to form benzo, or a 5- or 6-membered aromatic heterocyle, wherein benzo, and the 5- or 6-membered aromatic heterocyle are optionally substituted with one or more R 8 , which are the same or different; 
         R 8  is halogen, CN, C(O)OR 6 , OR 6 , C(O)N(R 6 R 6a ), S(O) 2 N(R 6 R 6a ), S(O)N(R 6 R 6a ), S(O) 2 R 6 , N(R 6 )S(O) 2 N(R 6a R 6b ), SR 6 , N(R 6 R 6a ), NO 2 , OC(O)R 6 , N(R 6 )C(O)R 6a , N(R 6 ) S(O) 2 R 6a , N(R 6 )S(O)R 6a , N(R 6 )C(O)N(R 6a R 6b ), N(R 6 )C(O)OR 6a , OC(O)N(R 6 R 6a ), C(O)R 6 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, or T, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 7 , which are the same or different; 
         R 6 , R 6a , and R 6b  are independently selected from the group consisting of H, T, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 9 , which are the same or different; 
         R 7  and R 9  are independently selected from the group consisting of halogen, C(O)R 10 , CN, C(O)OR 10 , OR 10 , C(O)N(R 10 R 10a ), S(O) 2 N(R 10 R 10a ), S(O)N(R 10a ), S(O) 2 R 10 , N(R 10 )S(O) 2 N(R 10a R 10b ), SR 10 , N(R 10 R 10a ), NO 2 OC(O)R 10 , N(R 10 )C(O)R 10a , N(R 10 )S(O) 2 R 10a , N(R 10 )S(O)R 10a , N(R 10 )C(O)N(R 10a R 10b ), N(R 10 )C(O)R 10a , OC(O)N(R 10 R 10a ), and T 1 ; 
         R 10 , R 10a , and R 10b  are independently selected from the group consisting of H, T 1 , C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 11 , which are the same or different; 
         R 11  is halogen, C(O)R 12 , CN, C(O)OR 12 , OR 12 , C(O)N(R 12 R 12a ), S(O) 2 N(R 12 R 12a ), S(O)N(R 12 R 12a ), S(O) 2 R 12 ; N(R 12 )S(O) 2 N(R 12a R 12b ), SR 12 , N(R 12 R 12a ), NO 2 , OC(O)R 12 , N(R 12 )C(O)R 12a , N(R 12 )S(O) 2 R 12a , N(R 12 )S(O)R 12a , N(R 12 )C(O)N(R 12a R 12b ), N(R 12 )C(O)OR 12a , or OC(O)N(R 12 R 12a ); 
         R 12 , R 12a , and R 12b  are independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; 
         T and T 1  are independently selected from the group consisting of phenyl, naphthyl, indenyl, indanyl, tetralinyl, decalinyl, adamantyl, C 3-7  cycloalkyl, 4 to 7 membered heterocyclyl, and 8 to 11 membered heterobicyclyl, wherein T, T 1  are optionally substituted with one or more R 13 , which are the same or different; 
         R 13  is halogen, CN, C(O)R 14 , COOR 14 , OR 14 , C(O)N(R 14 R 14a ), S(O) 2 N(R 14 R 14a ), S(O)N(R 14 R 14a ), S(O) 2 R 14 , N(R 14 )S(O) 2 N(R 14a R 14b ), SR 14 , N(R 14 R 14a ), NO 2 , OC(O)R 14 , N(R 14 )C(O)R 14a , N(R 14 )S(O) 2 R 14a ; N(R 14 )S(O)R 14a , N(R 14 )C(O)N(R 14a R 14b ), N(R 14 )C(O)OR 14a , OC(O)N(R 14 R 14a ), oxo (═O), where the ring is at least partially saturated, C 1-6  alkyl, C 2-6  alkenyl, or C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; 
         R 14 , R 14a , and R 14b  are independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; 
         R 1  is H, T 2 , C 1-8  alkyl, C 2-8  alkenyl, and C 2-8  alkynyl, wherein C 1-8  alkyl, C 2-8  alkenyl, and C 2-8  alkynyl are optionally substituted with one or more R 15 , which are the same or different; 
         R 15  is halogen, C(O)R 16 , CN, C(O)OR 16 , OR 16 , C(O)N(R 16 R 16a ), S(O) 2 N(R 16 R 16a ), S(O)N(R 16 R 16a ), S(O) 2 R 16 , N(R 16 )S(O) 2 N(R 16a R 16b ), SR 16 , N(R 16 R 16a ), NO 2 , OC(O)R 16 , N(R 16 )C(O)R 16a , NR 16 )S(O) 2 R 16a , N(R 16 )S(O) R   16a , N(R 16 )C(O)NR 16a R 16b ), N(R 16 )C(O)OR 16a , OC(O)N(R 16 R 16a ), or cyclopropyl; 
         R 16 , R 16a , and R 16b  are independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; 
         T 2  is phenyl, C 3-7  cycloalkyl, or 4 to 7 membered heterocyclyl, wherein T 2  is optionally substituted with one or more R 17 , which are the same or different; 
         R 17  is halogen, CN, C(O)R 18 , C(O)OR 18 , OR 18 , C(O)N(R 18 R 18a ), S(O) 2 N(R 18 R 18a ), S(O)N(R 18 R 18a ), S(O) 2 R 18 , N(R 18 )S(O) 2 N(R 18a R 18b ), SR 18 , N(R 18 R 18a ), NO 2 , OC(O)R 18 , N(R 18 )C(O)R 18a , N(R 18 )S(O) 2 R 18a , N(R 18 )S(O)R 18a , N(R 18 )C(O)N(R 18a R 18b ), N(R 18 )C(O)OR 18a , OC(O)N(R 18 R 18a ), oxo (═O), where the ring is at least partially saturated, C 1-6  alkyl, C 2-6  alkenyl, or C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; 
         R 18 , R 18a , and R 18b  are independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; 
         R 1a  and R 1b  are independently selected from the group consisting of H, C 1-4  alkyl, wherein C 1-4  alkyl is optionally substituted with one or more halogen, which are the same or different; 
         X 1 , X 2 , and X 3  are independently selected from the group consisting of O, S, N, N(R 1c ), and C(R 1c ), provided that at least one of X 1 , X 2 , X 3  is other than C(R 1c ); 
         R 1c  is H, or CH 3 ; 
         R 2  is H, C 1-4  alkyl, C 2-4  alkenyl, or C 2-4  alkynyl, wherein C 1-4  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl are optionally substituted with one or more halogen, which are the same or different; 
         R 3  is T 3 , CH 2 -T 3 , CH(CH 3 )T 3 , CH 2 —CH 2 -T 3 , CH 2 —CH(T 3 ) 2 , or C 1-8  alkyl, wherein C 1-8  alkyl is substituted with one or more R 19 , which are the same or different; 
         Optionally, R 2 , R 3  are joined to form, together with the nitrogen atom to which they are attached, a ring, wherein the ring is a saturated 4 to 7 membered heterocycle, or a saturated 8 to 11 membered heterobicycle, wherein the ring contains said nitrogen atom and optionally one or more further heteroatoms, which are the same or different, and, wherein the ring is optionally substituted with one or more R 20 , which are the same or different; 
         R 19  is halogen, C(O)R 21 , CN, C(O)OR 21 , OR 21 , C(O)N(R 21 R 21a ), S(O) 2 N(R 21 R 21a ), S(O)N(R 21 R 21a ), S(O) 2 R 21 , N(R 21 )S(O) 2 N(R 21a R 21b ), SR 21 , N(R 21 R 21a ), NO 2 , OC(O)R 21 , N(R 21 )C(O)R 21a , N(R 21 )S(O) 2 R 21a , N(R 21 )S(O)R 21a , N(R 21 )C(O)N(R 21a R 21b ), N(R 21 )C(O)OR 21a , or OC(O)N(R 21 R 21a ); 
         R 21 , R 21a , an R 21b  are independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; 
         T 3  is phenyl, naphthyl, indenyl, indanyl, tetralinyl, decalinyl, adamantyl, C 3-7  cycloalkyl, 4 to 7 membered heterocyclyl, or 8 to 11 membered heterobicyclyl, wherein T 3  is optionally substituted with one or more R 22 , which are the same or different; 
         R 20  and R 22  are independently selected from the group consisting of halogen, CN, C(O)OR 23 , OR 23 , C(O)N(R 23 R 23a ), C(NR 23b )N(R 23 R 23a ), C(NR 23b )NR 23 )OR 23a , S(O) 2 N(R 23 R 23a ), S(O)N(R 23 R 23a ), S(O) 2 R 23 , N(R 23 )S(O) 2 N(R 23a R 23b ), SR 23 , N(R 23 R 23a ), NO 2 , OC(O)R 23 , N(R 23 )C(O) R   23a , N(R 23 )S(O) 2 R 23a , N(R 23 )S(O)R 23a , N(R 23 )C(O)N(R 23a R 23b ), N(R 23 )C(NR 23c )N(R 23a R 23b ), N(R 23 )C(O)OR 23a , OC(O)N(R 23 R 23a ), oxo (═O), where the ring is at least partially saturated, C(O)R 23 , C 1-10  alkyl, C 2-10  alkenyl, C 2-10  alkynyl, and T 4 , wherein C 1-10  alkyl, C 2-10  alkenyl, and C 2-10  alkynyl are optionally substituted with one or more R 24 , which are the same or different; 
         R 23 , R 23a , R 23b , and R 23c  are independently selected from the group consisting of H, T 4 , C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 25 , which are the same or different; 
         R 24  and R 25  are independently selected from the group consisting of halogen, CN, C(O)R 26 , C(O)OR 26 , OR 26 , C(O)R 26 , C(O)N(R 26 R 26a ), S(O) 2 N(R 26 R 26a ), R 26a ), S(O)N(R 26 R 26a ), S(O) 2 R 26 , N(R 26 )S(O) 2 N(R 26a R 26b ), SR 26 , N(R 26 R 26a ), OC(O)R 26 , N(R 26 )C(O)R 26a , N(R 26 )SO 2 R 26a , N(R 26 )S(O) R   26a , N(R 26 )C(O)N(R 26a R 26 ), NR 26 )C(O)OR 26a , OC(O)N(R 26 R 26a ), C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl and T 4 , wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 27 , which are the same or different; 
         R 26 , R 26a , and R 26b  are independently selected from the group consisting of H, T 4 , C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 28 , which are the same or different; 
         R 27 , R 28  are independently selected from the group consisting of halogen, CN, C(O)OR 29 , OR 29 , C(O)R 29 , C(O)N(R 29 R 29a ), S(O) 2 N(R 29 R 29a ), S(O)N(R 29 R 29a ), S(O) 2 R 29 , N(R 29 )S(O) 2 N(R 29a R 29b ), SR 29 , N(R 29 R 29a ), NO 2 , OC(O)R 29 , N(R 29 )C(O)R 29a , N(R 29 )SO 2 R 29a , N(R 29 )S(O)R 29a , N(R 29 )C(O)N(R 29a R 29b ), N(R 29 )C(O)OR 29a , OC(O)N(R 29 R 29a ), C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and T 4 , wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 30 , which are the same or different; 
         R 29 , R 29a , and R 29b  are independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and T 4 , wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 31 , which are the same or different; 
         T 4  is phenyl, naphthyl, indenyl, indanyl, tetralinyl, decalinyl, adamantyl, C 3-7  cycloalkyl, 4 to 7 membered heterocyclyl, or 8 to 11 membered heterobicyclyl, wherein T 4  is optionally substituted with one or more R 32 , which are the same or different; 
         R 32  is halogen, CN, C(O)OR 33 , OR 33 , C(O)N(R 33 R 33a ), C(NR 33b )N(R 33 R 33a ), C(NR 33b )N(R 33 )OR 33a , S(O) 2 N(R 33 R 33a ), S(O)N(R 33 R 33a ), S(O) 2 R 33 , N(R 33 )S(O) 2 N(R 33a R 33b ), SR 33 , N(R 33 R 33a ), NO 2 , OC(O)R 33 , N(R 33 )C(O)R 33a , N(R 33 )S(O) 2 R 33a , N(R 33 )S(O)R 33a , N(R 33 )C(O)N(R 33a R 33b ), N(R 33 )C(NR 33c )N(R 33a R 33b ), N(R 33 )C(O)OR 33a , OC(O)N(R 33 R 33a ), oxo (═O), where the ring is at least partially saturated, C(O)R 33 , T 5 , C 1-6  alkyl, C 2-6  alkenyl, or C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more R 34 , which are the same or different; 
         R 33 , R 33a , R 33b , and R 33c  are independently selected from the group consisting of H, T 5 , C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same of different; 
         R 30 , R 31 , and R 34  are independently selected from the group consisting of halogen, CN, C(O)OR 35 , OR 35 , C(O)R 35 , C(O)N(R 35 R 35a ), S(O) 2 N(R 35 R 35a ), S(O)N(R 35 R 35a ), S(O) 2 R 35 , N(R 35 )S(O) 2 N(R 35a R 35b ), SR 35 , N(R 35 R 35a ), NO 2 , OC(O)R 35 , N(R 35 )C(O)R 35a , N(R 35 )SO 2 R 35a , N(R 35 )S(O)R 35a , N(R 35 )C(O)N(R 35a R 35b ), N(R 35 )C(O)OR 35a , OC(O)N(R 35 R 35a ), T 5 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same of different; 
         R 35 , R 35a , and R 35b  are independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same of different; 
         T 5  is phenyl, C 3-7  cycloalkyl, or 4 to 7 membered heterocyclyl, wherein T 5  is optionally substituted with one or more R 36 , which are the same or different; 
         R 36  is independently selected from the group consisting of halogen, CN, C(O)OR 37 , OR 37 , C(O)N(R 37 R 37a ), C(NR 37b )N(R 37 R 37a ), C(NR 37 )N(R 37 )OR 37a , S(O) 2 N(R 37 R 37a ), S(O)N(R 37 R 37a ), S(O) 2 R 37 , N(R 37 )S(O) 2 N(R 37a R 37b ), SR 37 , N(R 37 R 37a ), NO 2 , OC(O)R 37 , N(R 37 )C(O)R 37a , N(R 37 )S(O) 2 R 37a , N(R 37 )S(O) R   37a , N(R 37 )C(O)N(R 37a R 37b ), N(R 37 )C(NR 37c )N(R 37a R 37b ), N(R 37 )C(O)OR 37a , OC(O)N(R 37 R 37a ), oxo (═O), where the ring is at least partially saturated, C(O)R 37 , C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; and 
         R 37 , R 37a , R 37b , and R 37c  are independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl, wherein C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same of different, 
         provided that compounds having all of the following substituents are excluded from formula (I): 
         X is phenyl, is substituted with R 4  and is optionally substituted with one or more R 5 , which are the same or different; 
         R 1  is H or C 1-8  alkyl, wherein C 1-8 alkyl is optionally substituted with one or more R 15 , which are the same or different; 
         X 1  is O or C(R 1c ), X 2  is O, and X 3  is C(R 1c ); and 
         R 2 , R 3  are joined to form, together with the nitrogen atom to which they are attached, a ring, wherein the ring is a saturated 4 to 7 membered heterocycle, wherein the ring contains said nitrogen atom and optionally one or more further heteroatoms, which are the same or different, and, wherein the ring is optionally substituted with one or more R 20 , which are the same or different. 
       
     
     
         2 . The compound of  claim 1 , wherein X is phenyl, or thiophene, and wherein X is substituted with R 4  and is optionally substituted with one or more R 5 , which are the same or different. 
     
     
         3 . The compound of  claim 1 , wherein two adjacent R 5  are joined together with the atoms to which they are attached to form benzo and wherein benzo is optionally substituted with one or more R 8 , which are the same or different. 
     
     
         4 . The compound of  claim 1 , wherein X is substituted in 2-position relative to the sulfonamide group in formula (I) with R 4  and is optionally substituted with one or more R 5 , which are the same or different. 
     
     
         5 . The compound of  claim 1 , wherein R 4 , R 5 , R 8  are independently selected from the group consisting of CH 3 , CF 3 , CH 2 CH 3 , CH 2 OH, OCH 3 , Cl, Br, and phenyl. 
     
     
         6 . The compound of  claim 1 , wherein R 1  is methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, phenyl, or cyclopropylmethyl. 
     
     
         7 . The compound of  claim 1 , wherein R 1a , R 1b  are independently selected from the group consisting of H, and methyl. 
     
     
         8 . The compound of  claim 1  of one of the formulae (Ia) to (Im) 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         wherein X, R 1 , R 1a , R 1b , R 2 , R 3  have the meaning as indicated in  claim 1 . 
       
     
     
         9 . The compound of  claim 1 , wherein R 2  is H; or CH 3 . 
     
     
         10 . The compound of  claim 1 , wherein R 2 , R 3  are joined to form a ring selected from the group consisting of piperidine; piperazine; morpholine; 2,8-diazaspiro[4.5]decane; pyrrolidine; and diazepane, wherein the ring is optionally substituted with one or more R 20 , which are the same or different. 
     
     
         11 . The compound of  claim 1 , wherein R 3  is CH 2 -T 3 , CH 2 —CH(CH 3 )-T 3 , or CH 2 —CH 2 -T 3 . 
     
     
         12 . The compound of  claim 1 , wherein T 3  is phenyl; or pyridine. 
     
     
         13 . The compound of  claim 1 , wherein R 20 , R 22  are independently selected from the group consisting of CN, C(O)N(R 23 R 23a ), C(NR 23b )N(R 23 R 23a ), C(NR 23b )N(R 23 )OR 23a , N(R 23 R 23a ), N(R 23 )C(O)N(R 23a R 23b ), C(O)R 23 , N(R 23 )C(NR 23c )N(R 23a R 23b ), C 1-6  alkyl, and T 4 , wherein C 1-6  alkyl is optionally substituted with one or more R 24 , which are the same or different. 
     
     
         14 . The compound of  claim 1 , wherein one of R 23 , R 23a , R 23b , R 23c  is T 4 . 
     
     
         15 . The compound of  claim 1 , wherein R 24  is T 4 . 
     
     
         16 . The compound of  claim 1 , wherein T 4  is selected from the group consisting of pyrrole, pyrrolidine, imidazole, 4,5-dihydroimidazole, oxazolidine, tetrahydrofuran, pyridine, piperidine, morpholine, pyrimidine, and 3,4,5,6-tetrahydropyrimidine, and wherein T 4  is optionally substituted with one or more R 32 , which are the same or different. 
     
     
         17 . The compound of  claim 1 , wherein R 32  is C 1-4  alkyl, oxo (═O), wherein the ring is at least partially saturated, NH 2 , F, or C(O)CF 3 . 
     
     
         18 . The compound of  claim 1 , selected from the group consisting of:
 N-[4-(1H-imidazol-1-yl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-(1,2,2,6,6-pentamethylpiperidin-4-yl)furan-3-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{2-[4-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[3-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[4-(1,4,5,6-tetrahydropyrimidin-2-yl)benzyl]furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-[3-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   2-({4-[({[5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-yl]carbonyl}amino)methyl]phenyl}amino)-1-methylpyridinium iodide,   2-({4-[2-({[5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-yl]carbonyl}amino)ethyl]phenyl}amino)-1-methylpyridinium iodide,   N-{4-[(4-aminopyrimidin-2-yl)amino]benzyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide,   5-({[(4-bromo-2-ethylphenyl)sulfonyl](methyl)amino}methyl)-N-[3-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   5-({[(4-bromo-2,6-dichlorophenyl)sulfonyl](methyl)amino}methyl)-N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-N-methylfuran-3-carboxamide,   5-({[(4-chloro-2,5-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-N-methylfuran-3-carboxamide,   5-({[(2,4-dichlorophenyl)sulfonyl](methyl)amino}methyl)-N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-N-methylfuran-3-carboxamide,   5-({[(2,4-dichlorophenyl)sulfonyl](methyl)amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methylfuran-3-carboxamide,   5-({[(2,6-dichlorophenyl)sulfonyl](methyl)amino}methyl)-N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-N-methylfuran-3-carboxamide,   5-({[(4-bromo-2,6-dichlorophenyl)sulfonyl](methyl)amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methylfuran-3-carboxamide,   5-({[(4-bromo-2,6-dichlorophenyl)sulfonyl](methyl)amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}furan-3-carboxamide,   5-({[(2,6-dichlorophenyl)sulfonyl](methyl)amino}methyl)-N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]furan-3-carboxamide,   5-({[(4-bromo-2,6-dichlorophenyl)sulfonyl](methyl)amino}methyl)-N-[4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   5-({[(4-chloro-2,5-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methylfuran-3-carboxamide,   N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   N-(2-{4-[(3aR,7aR)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazol-2-yl]phenyl}ethyl)-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-[4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-(4-pyrimidin-5-ylbenzyl)furan-3-carboxamide,   N-[4-(5,5-dimethyl-1,4,5,6-tetrahydropyrimidin-2-yl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-[2-(4-{[(2-methylpropyl)amino]methyl}phenyl)ethyl]furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[4-(1-methyl-1H-imidazol-2-yl)benzyl]furan-3-carboxamide,   N-(2-{4-[(4-aminopyrimidin-2-yl)amino]phenyl}ethyl)-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide,   N-(2-{4-[(2-aminopyrimidin-4-yl)amino]phenyl}ethyl)-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{2-[4-(pyrrolidin-1-ylmethyl)phenyl]ethyl}furan-3-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({ethyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methylfuran-3-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](1-methylethyl)amino}methyl)-N-methylfuran-3-carboxamide,   5-({(Cyclopropylmethyl)[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}furan-3-carboxamide,   N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](phenyl)amino}methyl)-N-methylfuran-3-carboxamide,   5-({Cyclobutyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methylfuran-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}furan-3-carboxamide,   N-cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[3-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[3-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide,   N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N,2-dimethylfuran-3-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N,2-dimethylfuran-3-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-2-methylfuran-3-carboxamide,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-3-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,2,4-thiadiazole-5-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-3-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,2,4-oxadiazole-5-carboxamide,   4-Methoxy-N,2,6-trimethyl-N-[(3-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}isoxazol-5-yl)methyl]benzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-[(4-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3-oxazole-4-carboxamide,   N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3-oxazole-4-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   2({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[3-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-[3-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[3-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[3-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methyl-1,3-oxazole-4-carboxamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-thiazole-4-carboxamide,   N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-thiazole-4-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]furan-3-carboxamide trifluoroacetate,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-N-methylfuran-3-carboxamide trifluoroacetate,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methylfuran-3-carboxamide trifluoroacetate,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-(1-{[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}ethyl)furan-3-carboxamide trifluoroacetamide,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-{[{[2-(hydroxymethyl)-4-methoxy-6-methylphenyl]sulfonyl}(methyl)amino]methyl}furan-3-carboxamide trifluoroacetate,   N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-hydroxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide, trifluoroacetate,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[4-(1-pyrrolidin-1-ylethyl)benzyl]furan-3-carboxamide trifluoroacetate,   N-cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)furan-2-yl]methyl}benzenesulfonamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{1-[4-(pyrrolidin-1-ylmethyl)phenyl]ethyl}furan-3-carboxamide,   N-(1-{4-[(3-hydroxypyrrolidin-1-yl)methyl]phenyl}ethyl)-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide,   N-[2-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]methyl}phenyl)ethyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide trifluoroacetate,   N-[4-(5,5-Dimethyl-4,5-dihydro-1H-imidazol-2-yl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide trifluoroacetate,   N-{2-[4-(5,5-Dimethyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide trifluoroacetate,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-(4-{[(pyridin-4-ylmethyl)amino]methyl}benzyl)furan-3-carboxamide trifluoroacetate,   N-[4-(azetidin-1-ylmethyl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide trifluoroacetate,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-{2-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}furan-3-carboxamide trifluoroacetamide,   5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(2-methylpiperidin-1-yl)methyl]benzyl}furan-3-carboxamide trifluoroacetate,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-[4-(piperidin-1-ylmethyl)benzyl]furan-3-carboxamide trifluoroacetate,   N-[4-(Azepan-1-ylmethyl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide trifluoroacetate,   5-({Ethyl [(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide trifluoroacetate,   N-[4-(4,5-Dihydro-1H-imidazol-2-yl)benzyl]-5-({ethyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methylfuran-3-carboxamide trifluoroacetate,   N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({ethyl [(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)furan-3-carboxamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)furan-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}carbonyl)furan-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(1,2,2,6,6-pentamethylpiperidin-4-yl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-piperidin-1-ylethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-pyridin-4-ylethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(pyridin-3-ylmethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[2-(4-ethylpiperazin-1-yl)ethyl]furan-3-carboxamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-pyridin-2-ylethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(3-pyrrolidin-1-ylpropyl)-1,4-diazepan-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   2-(4-{[5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)furan-3-yl]carbonyl}piperazin-1-yl)-N-pyridin-3-ylacetamide trifluoroacetate,   N-Cyclopropyl-N-{[4-({4-[3-(dimethylamino)propyl]piperazin-1-yl}carbonyl)furan-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide trifluoroacetate,   5-({[(2,6-Dichlorophenyl)sulfonyl](ethyl)amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide trifluoroacetate,   5-({[(2,6-Dichlorophenyl)sulfonyl](ethyl)amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}furan-3-carboxamide trifluoroacetate,   5-({[(4-Bromo-2,6-dichlorophenyl)sulfonyl](cyclopropyl)amino}methyl)-N-[4-(4,5-dihydro-1H-imidazol-2-yl)benzyl]-N-methylfuran-3-carboxamide trifluoroacetate,   5-({[(4-Bromo-2,6-dichlorophenyl)sulfonyl](cyclopropyl)amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methylfuran-3-carboxamide trifluoroacetate,   4-Bromo-2,6-dichloro-N-cyclopropyl-N-{[4-({3-[4-(pyrrolidin-1-ylmethyl)phenyl]piperidin-1-yl}carbonyl)furan-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-{4-[(4-Hydroxypiperidin-1-yl)methyl]benzyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{44(4-methoxypiperidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   N-{4-[(3-Hydroxyazetidin-1-yl)methyl]benzyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(3-methoxypyrrolidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(3-methoxypiperidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   1-(4-{[{[5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-yl]carbonyl}(methyl)amino]methyl}benzyl)-N,N-dimethylpyrrolidine-3-carboxamide,   N-(4-{[3-(Acetylamino)pyrrolidin-1-yl]methyl}benzyl)-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   N-{4-[(3-Methoxyazetidin-1-yl)methyl]benzyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   N-{4-[(3-Hydroxypiperidin-1-yl)methyl]benzyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   N-{4-[(3-Hydroxypyrrolidin-1-yl)methyl]benzyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   N-(4-{[3-(Dimethylamino)pyrrolidin-1-yl]methyl}benzyl)-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-{[5-(pyrrolidin-1-ylmethyl)-1,3,4-thiadiazol-2-yl]methyl}furan-3-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-{[4-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2-yl]methyl}furan-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(4-hydroxypiperidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-(4-{[3-(dimethylamino)pyrrolidin-1-yl]methyl}benzyl)-N-methylfuran-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{44(3-hydroxypyrrolidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-hydroxypiperidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(4-methoxypiperidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-methoxypiperidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-methoxypyrrolidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   N-(4-{[3-(Acetylamino)pyrrolidin-1-yl]methyl}benzyl)-5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methylfuran-3-carboxamide,   1-(4-{[{[5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)furan-3-yl]carbonyl}(methyl)amino]methyl}benzyl)-N,N-dimethylpyrrolidine-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-hydroxyazetidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-methoxyazetidin-1-yl)methyl]benzyl}-N-methylfuran-3-carboxamide,   N-Ethyl-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-[4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide trifluoroacetate,   N-[2-Fluoro-5-(pyrrolidin-1-ylmethyl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide trifluoroacetate,   N-[3-Fluoro-4-(pyrrolidin-1-ylmethyl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide trifluoroacetate,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[2-fluoro-5-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide trifluoroacetate,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[3-fluoro-4-(pyrrolidin-1-ylmethyl)benzyl]furan-3-carboxamide trifluoroacetate,   N-[3-Fluoro-5-(pyrrolidin-1-ylmethyl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide trifluoroacetate,   N-[2-Fluoro-5-(pyrrolidin-1-ylmethyl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide trifluoroacetate,   N-[3-Fluoro-4-(pyrrolidin-1-ylmethyl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide trifluoroacetate,   N-[3-Fluoro-5-(pyrrolidin-1-ylmethyl)benzyl]-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methylfuran-3-carboxamide trifluoroacetate,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-{4-[(1-oxidopyrrolidin-1-yl)methyl]benzyl}-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-(2-piperidin-3-ylethyl)-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-{[2-(pyrrolidin-1-ylmethyl)-1,3-thiazol-4-yl]methyl}-1,3-oxazole-4-carboxamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-({4-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]-1,3-oxazol-2-yl}methyl)benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(pyridin-4-ylmethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(pyridin-3-ylmethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-[(4-{[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide,   N-{4-[(4-Hydroxypiperidin-1-yl)methyl]benzyl}-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(4-methoxypiperidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(3-methoxypiperidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(3-methoxypyrrolidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   N-(4-{[3-(Acetylamino)pyrrolidin-1-yl]methyl}benzyl)-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   N-(4-{[3-(Dimethylcarbamoyl)pyrrolidin-1-yl]methyl}benzyl)-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   N-{4-[(3-Hydroxyazetidin-1-yl)methyl]benzyl}-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   N-{4-[(3-Methoxyazetidin-1-yl)methyl]benzyl}-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   4-Methoxy-N,2,6-trimethyl-N-[(4-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-{[4-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl)methyl}benzenesulfonamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-hydroxypyrrolidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   N-(4-{[3-(Dimethylamino)pyrrolidin-1-yl]methyl}benzyl)-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   N-{4-[(3-Hydroxypyrrolidin-1-yl)methyl]benzyl}-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   N-{4-[(3-Hydroxypiperidin-1-yl)methyl]benzyl}-2-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino methyl)-N-{4-[(3-hydroxypiperidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino methyl)-N-{4-[(4-hydroxypiperidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino methyl)-N-{4-[(3-methoxypyrrolidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(4-methoxypiperidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-methoxypiperidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   N-(4-{[3-(Acetylamino)pyrrolidin-1-yl]methyl}benzyl)-2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-(4-{[3-(dimethylcarbamoyl)pyrrolidin-1-yl]methyl}benzyl)-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino methyl)-N-{4-[(3-methoxyazetidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-hydroxyazetidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3,4-dihydroxypyrrolidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-(4-{[3-(dimethylamino)pyrrolidin-1-yl]methyl}benzyl)-N-methyl-1,3-oxazole-4-carboxamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-piperidin-1-ylethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-N-{[4-({4-[3-(dimethylamino)propyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-{4-[(3-hydroxy-3-methylpyrrolidin-1-yl)methyl]benzyl}-N-methyl-1,3-oxazole-4-carboxamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-{[5-(pyrrolidin-1-ylmethyl)-1,3,4-thiadiazol-2-yl]methyl}-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-{[4-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2-yl]methyl}-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-{[5-(pyrrolidin-1-ylmethyl)-1,3,4-thiadiazol-2-yl]methyl}-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-{[4-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2-yl]methyl}-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-{[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]methyl}-1,3-oxazole-4-carboxamide,   N-Cyclopropyl-N-{[4-({4-[4-(dimethylamino)butyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-(octahydro-2H-pyrrolo[3,4-c]pyridin-2-ylcarbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[5-(1-methylpiperidin-4-yl)octahydro-2H-pyrrolo[3,4-c]pyridin-2-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-[(4-{[5-(1-Azabicyclo[2.2.2]oct-3-yl)octahydro-2H-pyrrolo[3,4-c]pyridin-2-yl]carbonyl}-1,3-oxazol-2-yl)methyl]-N-cyclopropyl-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({3-[methyl(1-methylpiperidin-4-yl)amino]pyrrolidin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-N-{[4-({5-[(6-methoxypyridin-3-yl)methyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-N-{[4-({5-[(6-methoxypyridin-3-yl)methyl]octahydro-2H-pyrrolo[3,4-c]pyridin-2-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({5-[(6-pyrrolidin-1-ylpyridin-3-yl)methyl]octahydro-2H-pyrrolo[3,4-c]pyridin-2-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-N-({4-[(3-{[(6-methoxypyridin-3-yl)methyl](methyl)amino}pyrrolidin-1-yl)carbonyl]-1,3-oxazol-2-yl}methyl)-2,6-dimethylbenzenesulfonamide trifluoroacetate,   2-({Cyclopropyl[(2,6-dichlorophenyl)sulfonyl]amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methyl-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({Cyclopropyl[(2,4-dichlorophenyl)sulfonyl]amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methyl-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({Cyclopropyl[(2,4,6-trichlorophenyl)sulfonyl]amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methyl-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({Cyclopropyl[(2,4,6-trichlorophenyl)sulfonyl]amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({[(4-Chloro-2,5-dimethylphenyl)sulfonyl](cyclopropyl)amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methyl-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({[(4-Chloro-2,5-dimethylphenyl)sulfonyl](cyclopropyl)amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({[(2-Chloro-6-methylphenyl)sulfonyl](cyclopropyl)amino}methyl)-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methyl-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({[(2-Chloro-6-methylphenyl)sulfonyl](cyclopropyl)amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide trifluoroacetate,   2-[(Cyclopropyl {[2-(trifluoromethyl)phenyl]sulfonyl}amino)methyl]-N-{2-[4-)-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-N-methyl-1,3-oxazole-4-carboxamide trifluoroacetate,   2-[(Cyclopropyl {[2-(trifluoromethyl)phenyl]sulfonyl}amino)methyl]-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3-oxazole-4-carboxamide trifluoroacetate,   N-Cyclopropyl-N-{[4-({4-hydroxy-4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-N-[(4-{[4-hydroxy-4-(morpholin-4-ylmethyl)piperidin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[(2-methyl-2,3-dihydro-1H-isoindol-5-yl)methyl]-1,3-oxazole-4-carboxamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-((4-[(4-pyridin-3-ylpiperazin-1-yl)carbonyl]-1,3-oxazol-2-yl]methyl)benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(pyridin-2-ylmethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(2-pyridin-2-ylethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(4-methylpiperazin-1-yl)carbonyl]piperidin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(piperidin-4-ylmethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-({4-[(4-pyridin-4-ylpiperidin-1-yl)carbonyl]-1,3-oxazol-2-yl}methyl)benzenesulfonamide,   N-Cyclopropyl-N-{[4-({4-[(3-fluoropyridin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-N-{[4-({4-[(3,5-dichloropyridin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-N-{[4-({4-[(6-fluoropyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-N-{[4-({4-[(6-methoxypyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-({4-[(4-{[6-(trifluoromethyl)pyridin-3-yl]methyl}piperazin-1-yl)carbonyl]-1,3-oxazol-2-yl}methyl)benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(6-pyrrolidin-1-ylpyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-(2-piperidin-3-ylethyl)-1,3-oxazole-4-carboxamide trifluoroacetate,   N-{[4-(4,4′-Bipiperidin-1-ylcarbonyl)-1,3-oxazol-2-yl]methyl}-N-cyclopropyl-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-N-{[4-({4-hydroxy-4-[(E)-2-pyridin-3-ylethenyl]piperidin-1-yl}carbonyl)-1,3-oxazol-2-yl)methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-N-{[4-({4-hydroxy-4-[(E)-2-pyridin-4-ylethenyl]piperidin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-[3-(4-ethylpiperazin-1-yl)propyl]-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[4-(4-methylpiperazin-1-yl)cyclohexyl]-1,3-oxazole-4-carboxamide trifluoroacetate,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[3-(4-methylpiperazin-1-yl)cyclohexyl]-1,3-oxazole-4-carboxamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[2-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-5-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-N-({4-[(4-{[2-(dimethylamino)ethoxy]methyl}-4-hydroxypiperidin-1-yl)carbonyl]-1,3-oxazol-2-yl}methyl)-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(1-methylpyrrolidin-3-yl)oxy]piperidin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(1-methylpiperidin-3-yl)oxy]piperidin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   N-Cyclopropyl-N-[(4-{[4-(1H-imidazol-4-ylmethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]-4-methoxy-2,6-dimethylbenzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(2-methyl-1H-imidazol-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(1-methyl-1H-imidazol-5-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(2-methylpyridin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide,   N-{[4-({4-[(2-Aminopyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}-N-cyclopropyl-4-methoxy-2,6-dimethylbenzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(4-{[4-(quinolin-3-ylmethyl)piperazin-1-yl]carbonyl}-1,3-oxazol-2-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(3-methyl-1H-pyrazol-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[4-({4-[(2-pyrrolidin-1-ylpyridin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3-oxazol-2-yl]methyl}benzenesulfonamide,   2-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[2-(pyridin-4-yloxy)ethyl]-1,3-oxazole-4-carboxamide,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-{[(5-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl}benzenesulfonamide,   4-Methoxy-N-{[5-({4-[(6-methoxypyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-N,2,6-trimethylbenzenesulfonamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(6-pyrrolidin-1-ylpyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-({5-[(4-{[6-(trifluoromethyl)pyridin-3-yl]methyl}piperazin-1-yl)carbonyl]-1,3,4-oxadiazol-2-yl}methyl)benzenesulfonamide trifluoroacetate,   tert-Butyl 4-[(4-{[5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazol-2-yl]carbonyl}piperazin-1-yl)methyl]piperidine-1-carboxylate,   4-Methoxy-N,2,6-trimethyl-N-({5-[(4-{[1-(1-methylethyl)piperidin-4-yl]methyl}piperazin-1-yl)carbonyl]-1,3,4-oxadiazol-2-yl}methyl)benzenesulfonamide trifluoroacetate,   N-{[5-({4-[(1-Cyclobutylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide trifluoroacetate,   N-({5-[(4-{[1-(2-Hydroxy-2-methylpropyl)piperidin-4-yl]methyl}piperazin-1-yl)carbonyl]-1,3,4-oxadiazol-2-yl}methyl)-4-methoxy-N,2,6-trimethylbenzenesulfonamide,   N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3,4-oxadiazole-2-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3,4-oxadiazole-2-carboxamide trifluoroacetate,   N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl]benzenesulfonamide trifluoroacetamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[5-({4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-N-{[5-({4-[3-(dimethylamino)propyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl]benzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide,   N-{[5-({4-[3-(Dimethylamino)propyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl)methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-{[(5-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl]benzenesulfonamide,   5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3,4-oxadiazole-2-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(3-methoxypyrrolidin-1-yl)methyl]benzyl}-N-methyl-1,3,4-oxadiazole-2-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(4-methoxypiperidin-1-yl)methyl]benzyl}-N-methyl-1,3,4-oxadiazole-2-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-{4-[(3-methoxypiperidin-1-yl)methyl]benzyl}-N-methyl-1,3,4-oxadiazole-2-carboxamide,   N-(4-{[3-(Dimethylamino)pyrrolidin-1-yl]methyl}benzyl)-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3,4-oxadiazole-2-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-{[4-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2-yl]methyl}-1,3,4-oxadiazole-2-carboxamide,   N-{4-[(3-Methoxyazetidin-1-yl)methyl]benzyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3,4-oxadiazole-2-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[(2-methyl-2,3-dihydro-1H-isoindol-5-yl)methyl]-1,3,4-oxadiazole-2-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[3-(pyrrolidin-1-ylmethyl)benzyl]-1,3,4-oxadiazole-2-carboxamide,   4-Methoxy-2,6-dimethyl-N-{5-[4-(1-methyl-piperidin-4-ylmethyl)-piperazine-1-carbonyl]-1,3,4-oxadiazol-2-ylmethyl}-benzenesulfonamide,   4-Methoxy-2,6-dimethyl-N-( 2 H 3 )methyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(2-methyl-1H-imidazol-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methyl-1H-imidazol-5-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(2-methylpyridin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide,   N-{[5-({4-[(2-Aminopyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(quinolin-3-ylmethyl)piperazin-1-yl]carbonyl}-1,3,4-oxadiazol-2-yl)methyl]benzenesulfonamide,   N-{[5-({4-[(6-Chloropyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-({5-[(4-{[1-(trifluoroacetyl)piperidin-4-yl)methyl}piperazin-1-yl)carbonyl]-1,3,4-oxadiazol-2-yl}methyl)benzenesulfonamide trifluoroacetate,   N-{[5-({4-[4-(Dimethylamino)butyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide trifluoroacetate,   3-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,2,4-oxadiazole-5-carboxamide trifluoroacetamide,   N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-3-([(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,2,4-oxadiazole-5-carboxamide trifluoroacetamide,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-3-yl)methyl]benzenesulfonamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}benzenesulfonamide trifluoroacetamide,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-3-yl)methyl]benzenesulfonamide trifluoroacetamide,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}benzenesulfonamide trifluoroacetate,   3-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,2,4-oxadiazole-5-carboxamide trifluoroacetate,   3-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-{[4-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2-yl]methyl}-1,2,4-oxadiazole-5-carboxamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-3-yl)methyl]benzenesulfonamide,   N-{[5-({4-[3-(Dimethylamino)propyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl}-1,2,4-oxadiazol-3-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-3-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl}-1,2,4-oxadiazol-3-yl)methyl]benzenesulfonamide,   3-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-N-methyl-N-{[5-(pyrrolidin-1-ylmethyl)-1,3,4-thiadiazol-2-yl]methyl}-1,2,4-oxadiazole-5-carboxamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[5-({4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-N-{[5-({4-[3-(dimethylamino)propyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-3-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-3-yl)methyl]benzenesulfonamide,   N-[5-({4-[4-(Dimethylamino)butyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide trifluoroacetate,   N-Cyclopropyl-N-{[5-({4-[4-(dimethylamino)butyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}-4-methoxy-2,6-dimethylbenzenesulfonamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-{[3-({4-[(1-methyl)piperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-5-yl]methyl}benzenesulfonamide,   N-{[3-({4-[4-(Dimethylamino)butyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-5-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-[(3-{[4-(pyridin-3-ylmethyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-5-yl)methyl]benzene sulfonamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[3-(pyrrolidin-1-ylmethyl)benzyl]-1,2,4-oxadiazole-3-carboxamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-[(3-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide,   N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3,4-thiadiazole-2-carboxamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[4-(pyrrolidin-1-ylmethyl)benzyl]-1,3,4-thiadiazole-2-carboxamide,   N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxamide trifluoroacetamide,   5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-N-[3-(pyrrolidin-1-ylmethyl)benzyl]-1,3,4-thiadiazole-2-carboxamide trifluoroacetate,   4-Methoxy-N,2,6-trimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide trifluoroacetamide,   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-thiadiazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-thiadiazol-2-yl]methyl}benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide,   N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide, and   4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-4H-1,2,4-triazol-3-yl]methyl}benzenesulfonamide,   
     
     
         19 . A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof according to  claim 1  together with a pharmaceutically acceptable carrier, optionally in combination with one or more other pharmaceutical compositions. 
     
     
         20 . A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof according to  claim 1  together with a pharmaceutically acceptable carrier and comprising one or more additional compounds or pharmaceutically acceptable salts thereof selected from the group consisting of compounds according to  claim 1  and not being the first compound; or other Bradykinin B1 antagonists. 
     
     
         21 . A method of treating, controlling, delaying or preventing in a mammalian patient in need of treatment of one or more conditions selected from the group consisting of pain and inflammation including visceral pain (like pancreatitis, interstitial cystitis, renal colic, prostatitis, chronic pelvic pain), neuropathic pain (including postherpetic neuralgia, acute zoster pain, nerve injury, the “dynias”, including vulvodynia, phantom limb pain, root avulsions, radiculopathy, painful traumatic mononeuropathy, painful entrapment neuropathy, carpal tunnel syndrome, ulnar neuropathy, tarsal tunnel syndrome, painful diabetic neuropathy, painful polyneuropathy, trigeminal neuralgia), central pain syndromes (potentially caused by virtually any lesion at any level of the nervous system including but not limited to stroke, multiple sclerosis, spinal cord injury), and postsurgical pain syndromes (including postmastectomy syndrome, postthoracotomy syndrome, stump pain)), bone and joint pain (osteoarthritis), spine pain (including acute and chronic low back pain, neck pain, spinal stenosis), shoulder pain, repetitive motion pain, dental pain, sore throat, cancer pain, burn pain, myofascial pain (muscular injury, fibromyalgia), postoperative, perioperative pain and preemptive analgesia (including but not limited to general surgery, orthopedic, and gynecological), chronic pain, dysmenorrhea (primary and secodnary), as well as pain associated with angina, and inflammatory pain of varied origins (including osteoarthritis, rheumatoid arthritis, rheumatic disease, teno-synovitis and gout, ankylosing spondylitis, bursitis); hyperreactive airways and to treat inflammatory events associated with airways disease like asthma including allergic asthma (atopic or non-atopic) as well as exercise-induced bronchoconstriction, occupational asthma, viral- or bacterial exacerbation of asthma, other non-allergic asthmas and “wheezy-infant syndrome”; chronic obstructive pulmonary disease including emphysema, adult respiratory distress syndrome, bronchitis, pneumonia, allergic rhinitis (seasonal and perennial), and vasomotor rhinitis; pneumoconiosis, including aluminosis, anthracosis, asbestosis, chalicosis, ptilosis, siderosis, silicosis, tabacosis and byssinosis; inflammatory bowel disease including Crohn's disease and ulcerative colitis, irritable bowel syndrome, pancreatitis, nephritis, cystitis (interstitial cystitis), uveitis, inflammatory skin disorders including psoriasis and eczema, rheumatoid arthritis and edema resulting from trauma associated with burns, sprains or fracture, cerebral edema and angioedema (including hereditary angioedema and drug-induced angioedema including that caused by angiotensin converting enzyme (ACE) or ACE/neutral endopeptidase inhibitors like omepatrilat); diabetic vasculopathy, diabetic neuropathy, diabetic retinopathy, post capillary resistance or diabetic symptoms associated with insulitis (e.g. hyperglycemia, diuresis, proteinuria and increased nitrite and kallikrein urinary excretion); spasm of the gastrointestinal tract or uterus; liver disease, multiple sclerosis, cardiovascular disease, including atherosclerosis, congestive heart failure, myocardial infarct; neurodegenerative diseases, including Parkinson's and Alzheimers disease, epilepsy, septic shock, headache including cluster headache, migraine including prophylactic and acute use, stroke, closed head trauma, cancer, sepsis, gingivitis, osteoporosis, benign prostatic hyperplasia, hyperactive bladder, and obesity, which comprises administering to a patient in need thereof a compound according to  claim 1 . 
     
     
         22 . A method for the preparation of a compound according to  claim 1 , comprising the step of reacting a compound of formula (II) 
       
         
           
           
               
               
           
         
       
       with a compound of formula HN(R 2 )R 3  to yield a compound of formula (I).