Use of an ang-(1-7) receptor agonist in acute lung injury

Abstract

The present invention refers to a peptidic or non-peptidic angiotensin(1-7) (Ang-(1-7)) receptor agonist, preferably a Mas receptor agonist, for the prevention and/or treatment of acute lung injury, preferably acute respiratory distress syndrome.

1 . An Ang-(1-7) receptor agonist for use in the prevention and/or treatment of an acute lung injury in a subject. 
     
     
         2 . The receptor agonist according to  claim 1 , wherein the receptor agonist is a Mas receptor agonist. 
     
     
         3 . The receptor agonist according to  claim 1  or  2 , wherein the receptor agonist is a peptidic or non-peptidic agonist. 
     
     
         4 . The receptor agonist according to  claim 3 , wherein the peptidic agonist is an exogenous or endogenous Ang-(1-7) peptide comprising an amino acid sequence according to SEQ ID NO: 1 or is a derivative or analogue thereof. 
     
     
         5 . The receptor agonist according to  claim 3 , wherein the peptidic agonist is a peptide comprising an amino acid sequence according to SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4. 
     
     
         6 . The receptor agonist according to  claim 3 , wherein the peptidic agonist is an exogenous or endogenous NorAng-(1-7) peptide comprising an amino acid sequence according to SEQ ID NO: 5 or is a derivative or analogue thereof. 
     
     
         7 . The receptor agonist according to  claim 3 , wherein the peptidic agonist is an exogenous or endogenous Ang IV peptide comprising an amino acid sequence according to SEQ ID NO: 6 or is a derivative or analogue thereof. 
     
     
         8 . The receptor agonist according to  claim 3 , wherein the peptidic agonist is an exogenous or endogenous Ang III peptide comprising an amino acid sequence according to SEQ ID NO: 7 or is a derivative or analogue thereof. 
     
     
         9 . The receptor agonist according to  claim 3 , wherein the non-peptidic agonist is selected from the group of 1-(p-thienylbenzyl)imidazole compounds, preferably is Ave 0991. 
     
     
         10 . The receptor agonist according to any of  claims 1  to  9 , wherein the acute lung injury is an acute respiratory distress syndrome. 
     
     
         11 . The receptor agonist according to  claims 1  to  10 , wherein the acute lung injury is related to a pulmonary or an extrapulmonary lung injury.