Methods to treat nervous system conditions

Abstract

Methods to treat nervous system conditions. In at least one embodiment of a method of treating a mammalian patient having a neuronal injury or insult of the present disclosure, the method comprises the step of administering a therapeutically-effective dose of a stem cell conditioned medium to a mammalian patient, the stem cell conditioned medium comprising a cell culture supernatant containing at least one factor capable of exerting effective neuroprotection to treat a mammalian neural injury or insult.

1 . A method of treating a mammalian patient having a neuronal injury or insult, the method comprising the step of:
 administering a therapeutically-effective dose of an adipose tissue-derived stem cell conditioned medium to a mammalian patient, the stem cell conditioned medium comprising a cell culture supernatant containing at least one factor obtained from at least one adipose tissue-derived stem cell, the at least one factor capable of exerting effective neuroprotection to treat a mammalian neural injury or insult.   
     
     
         2 . The method of  claim 1 , wherein the neural injury or insult is an acute injury selected from the group consisting of an acute cerebral hypoxia, an acute spinal cord injury, an acute brain injury, and acute inflammation. 
     
     
         3 . The method of  claim 1 , wherein the neural injury or insult is a central nervous system injury selected from the group consisting of a brain injury and a spinal cord injury. 
     
     
         4 . The method of  claim 1 , wherein the neural injury or insult comprises a neurodegenerative disorder. 
     
     
         5 . The method of  claim 1 , wherein the neural injury or insult comprises a chronic injury. 
     
     
         6 . The method of  claim 5 , wherein the chronic injury is selected from the group consisting of Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, cerebral palsy, peripheral neuropathy, Huntington's disease, epilepsy, encephalomyelitis, encephalitis, a chronic spinal cord injury, a chronic brain injury, and chronic cerebral hypoxia. 
     
     
         7 . The method of  claim 1 , wherein the neural injury or insult comprises a hypoxia-ischemia of the brain selected from the group consisting of neonatal cerebral hypoxia and adult cerebral hypoxia. 
     
     
         8 . The method of  claim 1 , wherein the step of administering is performed by administering a therapeutically effective dose of a stem cell conditioned medium to a mammalian patient selected from the group consisting of a neonatal patient, a child, an adolescent, and an adult patient. 
     
     
         9 . The method of  claim 1 , wherein the step of administering is performed by systemically administering a therapeutically effective dose of a stem cell conditioned medium to a mammalian patient. 
     
     
         10 . The method of  claim 9 , wherein the systemic administration is selected from the group consisting of injection administration and intravenous administration. 
     
     
         11 . The method of  claim 1 , wherein the step of administering is performed by locally administering a therapeutically effective dose of a stem cell conditioned medium to a mammalian patient at or near a site of neural injury or insult. 
     
     
         12 . The method of  claim 11 , wherein the local administration is selected from the group consisting of interarterial administration, intravenous intraparenchymal administration, intrathecal administration, and interperitoneal administration. 
     
     
         13 . The method of  claim 1 , wherein the step of administering is performed to treat a mammalian neural injury or insult by treating neural cells in vivo that are at risk for hypoxia induced neuronal death. 
     
     
         14 . The method of  claim 1 , wherein the step of administering is performed to treat a mammalian neural injury or insult by treating cerebral tissues damaged by hypoxia. 
     
     
         15 . The method of  claim 1 , wherein the step of administering is performed to treat a mammalian neural injury or insult by stimulating neural cell regeneration. 
     
     
         16 . The method of  claim 1 , wherein the cell culture supernatant is produced by culturing at least one mammalian adipose stem cell to produce the at least one factor. 
     
     
         17 . A method of treating a mammalian patient having a neuronal injury or insult, the method comprising the step of:
 administering a therapeutically-effective dose of an adipose tissue-derived stem cell conditioned medium to a mammalian patient, the stem cell conditioned medium comprising a cell culture supernatant containing at least one factor obtained from at least one adipose tissue-derived stem cell, the at least one factor capable of exerting effective neuroprotection to treat a chronic mammalian neural injury or insult.   
     
     
         18 . A method of treating a mammalian patient having a neuronal injury or insult, the method comprising the step of administering a therapeutically-effective dose of an adipose tissue-derived medium containing at least one factor from a mammalian stem cell to a mammalian patient, the at least one factor from the mammalian stem cell capable to treat a mammalian neural injury or insult. 
     
     
         19 . The method of  claim 18 , wherein the mammalian stem cell is from a human patient, and wherein the mammalian patient comprises the human patient, and wherein the mammalian stem cell was obtained from the human patient. 
     
     
         20 . The method of  claim 18 , wherein the mammalian stem cell is from an animal patient, and wherein the mammalian patient comprises the animal patient, and wherein the mammalian stem cell was obtained from the animal patient.