Cyclohexyl Amide Derivatives and Their Use as CRF-1 Receptor Antagonists

Abstract

There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF 1 ) receptor antagonists.

1 . A compound of formula I; 
       
         
           
           
               
               
           
         
         in which R 1  is —(CH 2 ) n (SO 2 ) m R x ; 
         R x  is phenyl, biphenyl, naphthyl or heteroaryl, each of which may be optionally substituted by one or more substituents selected from the group alkyl C1 to 10, alkoxy C1 to 10, hydroxyalkyl C1 to 10, halogen, haloalkyl C1 to 10, haloalkoxy C1 to 10, nitrile, —CO 2 R 25 , —(CH 2 ) p NR 29 R 30 , —SO 2 NR 31 R 32 , alkoxy(C1 to 6)alkyl(C1 to 6)-, a 5- or 6-membered heterocycle, a 5- or 6-membered heteroaryl, phenyl, phenylalkyl(C1 to 6)-aryloxy, each of the 5- or 6-membered heterocycle, 5- or 6-membered heteroaryl, phenyl and aryloxy being optionally substituted by one or more substituents selected from the group, carboxy, alkyl C1 to 6, halogen and hydroxy; 
         R 2  is hydrogen or alkyl C1 to 6 or R 1  and R 2 , together with the nitrogen to which they are attached, form a 5- or 6-membered heteroaryl containing 2, 3 or 4 heteroatoms, the heteroaryl being optionally substituted by one or more substituents selected from the group alkyl C1 to 10, alkoxy C1 to 10, halogen, haloalkyl C1 to 10, haloalkoxy C1 to 10, phenyl or a 5- or 6-membered heterocycle, said heterocycle being optionally substituted by carboxy; 
         R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , R 17 , R 22 , R 25 , R 29 , R 30 , R 31  and R 32 , which may be the same or different, are each hydrogen or alkyl C1 to 6; 
         R 30  is hydrogen, alkyl C1 to 6 or R 33 CO—; 
         R 33  is alkyl C1 to 6; 
         R 8  is phenyl or a heteroaryl, each of which may be optionally substituted by one or more substituents selected from the group alkyl C1 to 6, haloalkyl C1 to 6, halogen, alkoxy C1 to 6, nitrile or dialkyl amino C1 to 6 or two adjacent substituents may together form a saturated or unsaturated carbocyclic or heterocyclic ring; 
         m is an integer 0 or 1; 
         n is an integer, 0, 1 or 2; 
         p is an integer from 0 to 6; 
         and isomers thereof; 
         in free form or in salt form. 
       
     
     
         2 . A compound according to  claim 1  wherein the compound is of formula II; 
       
         
           
           
               
               
           
         
         in which R 23  is hydrogen, alkyl C1 to 6, haloalkyl C1 to 6, dialkylamino C1 to 6, alkoxy C1 to 6 or halogen; 
         R 24  is alkyl C1 to 6, haloalkyl C1 to 6 or halogen; 
         A is —CH— or —N—; and 
         R 1  and R 7  are each as defined in  claim 1 ; 
         and isomers thereof; 
         in free form or in salt form. 
       
     
     
         3 . A compound according to  claim 1  wherein the compound is of formula III; 
       
         
           
           
               
               
           
         
         in which R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9  and R 10  are each as defined in  claims 1 ; and 
         R 11 , R 12 , R 13 , R 14  and R 15 , which may be the same or different, are each, hydrogen, halogen, alkyl C1 to 6, haloalkyl C1 to 6, alkoxy C1 to 6, halogenated alkoxy C1 to 6, nitrile, morpholinyl, sulphamoyl or R 11  and R 12  or R 12  and R 13  taken together may form a benzo or heteroaryl fused ring; 
         and isomers thereof; 
         in free form or in salt form. 
       
     
     
         4 . A compound according to  claim 1  wherein the compound is of formula IV; 
       
         
           
           
               
               
           
         
         in which R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9  and R 10  are each as defined in  claim 1 ; and 
         R 16  is a heteroaryl ring optionally substituted by one or more of alkyl C1 to 10, alkoxy C1 to 10, hydroxyalkyl C1 to 10, halogen, haloalkyl C1 to 10, halogenated alkoxy C1 to 10, nitrile, —CO 2 R 25 , alkylamino C1 to 6, dialkylamino C1 to 6, morpholinyl, phenyl, substituted phenyl, aryloxy, substituted phenoxy, imidazolinyl or oxoimidazolinyl; 
         and isomers thereof; 
         in free form or in salt form. 
       
     
     
         5 . A compound according to  claim 1  wherein the compound is of formula XI; 
       
         
           
           
               
               
           
         
         in which R 7  and R 8  are each as defined in  claim 1 ; and 
         R 18 , R 19  and R 20 , which may be the same or different, are each hydrogen, alkyl C1 to 10, alkoxy C1 to 10, halogen, haloalkyl C1 to 10, halogenated alkoxy, nitrile, morpholinyl, or, optionally substituted, phenyl, phenoxy, imidazolinyl or oxoimidazolinyl, or R 18  and R 19  or R 19  and R 20  may together form a saturated or unsaturated carbocyclic or heterocyclic ring; 
         and isomers thereof; 
         in free form or in salt form. 
       
     
     
         6 . A compound according to  claim 1  wherein the compound is of formula X; 
       
         
           
           
               
               
           
         
         in which R 1  is 2-pyridyl, 2-pyrimidinyl or 4-pyrazinyl each of which may optionally be substituted by one or more of alkyl C1 to 10, alkoxy C1 to 10, halogen, haloalkyl C1 to 10, halogenated alkoxy C1 to 10, nitrile, —CO 2 R 26 , —CH 2 NR 27 R 28 , morpholinyl, or optionally substituted phenyl, phenoxy, imidazolinyl or oxoimidazolinyl; or R 1  may optionally be fused to a substituted or unsubstituted benzo or heteroaryl ring; 
         R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , R 26 , R 27  and R 28 , which may be the same or different, are each hydrogen or alkyl C1 to 6; 
         R 8  is phenyl, a 5-membered heteroaryl, a 6-membered heteroaryl or a bicyclic system, each of which may optionally be substituted, by one or more of alkyl C1 to 6, halogenated alkyl C1 to 6, halogen, alkylamino C1 to 6, dialkylamino C1 to 6, alkoxy C1 to 6 or haloalkoxy C1 to 6; 
         and isomers thereof; 
         in free form or in salt form. 
       
     
     
         7 . A compound according to  claim 1  wherein the compound is of formula X; 
       
         
           
           
               
               
           
         
         in which R 1  is a 5-membered heteroaryl which may optionally be substituted by one or more of alkyl C1 to 10, alkoxy C1 to 10, halogen, haloalkyl C1 to 10, halogenated alkoxy C1 to 10, nitrile or morpholinyl; or phenyl, phenoxy, imidazolinyl or oxoimidazolinyl each of which may be optionally substituted, or R 1  may optionally be fused to a substituted or unsubstituted benzo or heteroaryl ring the substituents being selected from the group of alkyl C1 to 6, halo, haloalkyl C1 to 6, alkoxy C1 to 6, or carboxy; or together R 1  and R 2  form a ring, which may be optionally substituted; 
         R 2  is hydrogen or alkyl C1 to 6 or together R 1  and R 2  form a ring, which may be optionally be substituted; 
         R 3 , R 4 , R 5 , R 6 , R 7 , R 9  and R 10 , which may be the same or different, are each hydrogen or alkyl C1 to 6; 
         R 8  is phenyl, a 5-membered heteroaryl, a 6-membered heteroaryl or a bicyclic system, each of which may optionally be substituted, by one or more of alkyl C1 to 6, halogenated alkyl C1 to 6, halogen, alkylamino C1 to 6, dialkylamino C1 to 6, alkoxy C1 to 6 or haloalkoxy C1 to 6; 
         and isomers thereof; 
         in free form or in salt form. 
       
     
     
         8 . A compound according to  claim 1  which is selected from the group consisting of:
 trans-3-methyl-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-3-chloro-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-N-(4-Phenylaminomethyl-cyclohexyl)-2-trifluoromethyl-benzamide; 
 trans-3-cyano-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-3-methoxy-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-3-chloro-2-fluoro-N-(4-phenylaminomethyl-cyclohexyl)-6-trifluoromethyl-benzamide; 
 trans-N-{4-[(4-chloro-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-N-[4-(p-tolylamino-methyl)-cyclohexyl]-3-trifluoromethyl-benzamide; 
 trans-N-{4-[(3-chloro-4-methoxy-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-N-{4-[(4-isopropyl-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-N-{4-[(4-fluoro-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-3-trifluoromethyl-N-{4-[(4-trifluoromethyl-phenylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-N-{4-[(4-cyano-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-N-{4-[(3-chloro-4-cyano-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-N-[4-(naphthalen-1-ylaminomethyl)-cyclohexyl]-3-trifluoromethyl-benzamide; 
 trans-N-{4-[(3-cyano-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-N-{4-[(3-methoxy-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-N-[4-(quinolin-5-ylaminomethyl)-cyclohexyl]-3-trifluoromethyl-benzamide; 
 trans-N-[4-(quinolin-6-ylaminomethyl)-cyclohexyl]-3-trifluoromethyl-benzamide; 
 trans-N-{4-[(4-cyano-3-trifluoromethyl-phenylamino)-methyl]-cyclohexyl}-3-trifluoro methyl-benzamide; 
 trans-N-{4-[(4-morpholin-4-yl-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-phenylaminomethyl-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-([1,3,4]thiadiazol-2-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-methyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4-methyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2-methyl-1H-indol-5-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-5-trifluoromethyl-N-{4-[(1,3,5-trimethyl-1H-pyrazol-4-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-N-[4-(benzothiazol-2-ylaminomethyl)-cyclohexyl]-2-chloro-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[(5-phenyl-4H-[1,2,4]triazol-3-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1,3-dihydro-isobenzofuran-5-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[(2-phenyl-2H-[1,2,3]triazol-4-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[5-(4-fluoro-phenyl)-2H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2-methyl-3H-benzoimidazol-5-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1-methyl-1H-benzoimidazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1-methyl-1H-[1,2,4]triazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-propyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-isopropyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-cyclopropyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5,6-dimethyl-1H-benzoimidazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-N-(4-{[(benzooxazol-2-ylmethyl)-amino]-methyl}-cyclohexyl)-2-chloro-5-trifluoro methyl-benzamide; 
 trans-N-{4-[(1H-benzoimidazol-2-ylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-[4-(pyridin-3-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-N-{4-[(4-tert-butyl-phenylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3,4-dimethoxy-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-N-{4-[(3-bromo-4-methyl-phenylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-(4-{[methyl-(3-phenyl-[1,2,4]oxadiazol-5-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[methyl-(4-methyl-thiazol-2-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(methyl-phenyl-amino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[methyl-(5-phenyl-1H-pyrazol-3-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[methyl-(2-methyl-thiazol-4-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[methyl-(3-phenyl-isoxazol-5-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3-methoxy-4-methyl-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(6-methyl-quinolin-5-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(2,6-dimethyl-quinolin-5-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-(4-{[(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(quinolin-8-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(quinolin-6-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2-sulfamoyl-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(isoquinolin-1-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(6-chloro-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-ethyl-[1,3,4]thiadiazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-methyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4,6-dimethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(6-methoxy-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(3-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(6-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4,6-dimethoxy-pyrimidin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(thiazol-2-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-cyclopropyl-[1,3,4]thiadiazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2-fluoro-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2,4-difluoro-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2-fluoro-5-methyl-phenylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(2-chloro-5-methyl-phenylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(2-methoxy-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3-cyano-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3-fluoro-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3-chloro-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-5-trifluoromethyl-N-{4-[(3-trifluoromethyl-phenylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[(3,4-dimethyl-phenylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(3,5-dimethyl-phenylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4-methoxy-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4-ethoxy-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2-chloro-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3-isopropoxy-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1H-indol-5-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-N-[4-(benzo[1,3]dioxol-5-ylaminomethyl)-cyclohexyl]-2-chloro-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(quinolin-6-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4-trifluoromethoxy-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3-trifluoromethoxy-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-N-{4-[(2-benzenesulfonyl-ethylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoro methyl-benzamide; 
 trans-N-{4-[(5-tert-butyl-isoxazol-3-ylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[(5-phenyl-isoxazol-3-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[(3-phenyl-[1,2,4]oxadiazol-5-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[(3-phenyl-isoxazol-5-ylmethyl)-amino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3,5-dimethyl-isoxazol-4-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4-fluoro-3-trifluoromethyl-phenylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(6-phenoxy-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(8-methyl-quinolin-5-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 2-chloro-N-(2-methyl-4-phenylaminomethyl-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-N-{4-[3-(2-oxo-imidazolidin-1-yl)-pyrazol-1-ylmethyl]-cyclohexyl}-3-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[3-(2-oxo-imidazolidin-1-yl)-pyrazol-1-ylmethyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-methyl-N-(4-phenylaminomethyl-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2,5-dichloro-N-[4-(pyridin-3-ylaminomethyl)-cyclohexyl]-benzamide; 
 trans-2,5-dichloro-N-{4-[(6-trifluoromethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(6-cyano-pyridin-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-N-{4-[(6-acetylamino-pyridin-3-ylamino)-methyl]-cyclohexyl}-2,5-Dichloro-benzamide; 
 trans-2,5-dichloro-N-{4-[(6-methoxy-pyridin-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(6-chloro-pyridin-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(6-morpholin-4-yl-pyridin-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-(4-{[5-(4-fluoro-phenyl)-2H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-benzamide; 
 trans-2-chloro-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-5-methyl-benzamide; 
 trans-N-[4-(benzothiazol-2-ylaminomethyl)-cyclohexyl]-2,5-Dichloro-benzamide; 
 trans-2,5-dichloro-N-{4-[(1-methyl-1H-benzoimidazol-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[(2-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(6-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2,5-dichloro-N-{4-[(5-cyclopropyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-2,5-dichloro-N-(4-{[methyl-(5-phenyl-2H-pyrazol-3-ylmethyl)-amino]-methyl}-cyclohexyl)-benzamide; 
 trans-2-chloro-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-5-methoxy-benzamide; 
 trans-2-chloro-N-[4-(pyridin-2-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-chloro-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-5-trifluoromethyl-N-{4-[(5-trifluoromethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(5-propyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-5-trifluoromethyl-N-{4-[(6-trifluoromethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(6-trifluoromethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(6-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(5-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(4,6-dimethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[(6-methoxy-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2,5-dichloro-N-[4-(pyrazin-2-ylaminomethyl)-cyclohexyl]-benzamide; 
 trans-2-chloro-6-methyl-N-(4-phenylaminomethyl-cyclohexyl)-nicotinamide; 
 trans-5-methyl-N-(4-phenylaminomethyl-cyclohexyl)-nicotinamide; 
 trans-3H-indole-5-carboxylic acid (4-phenylaminomethyl-cyclohexyl)-amide; 
 trans-2-methyl-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-2,3-dimethyl-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-3-chloro-4-methyl-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-2,5-dichloro-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-4-fluoro-N-(4-phenylaminomethyl-cyclohexyl)-3-trifluoromethyl-benzamide; 
 trans-5-fluoro-N-(4-phenylaminomethyl-cyclohexyl)-2-trifluoromethyl-benzamide; 
 trans-2,5-dichloro-N-(4-phenylaminomethyl-cyclohexyl)-isonicotinamide; 
 trans-benzofuran-5-carboxylic acid (4-phenylaminomethyl-cyclohexyl)-amide; 
 trans-3-fluoro-N-(4-phenylaminomethyl-cyclohexyl)-benzamide; 
 trans-N-{4-[(4-Methoxy-phenylamino)-methyl]-cyclohexyl}-3-trifluoromethyl-benzamide; 
 trans-N-(4-phenylaminomethyl-cyclohexyl)-3-trifluoromethyl-benzamide; 
 trans-2,5-dichloro-N-{4-[3-(2-oxo-imidazolidin-1-yl)-pyrazol-1-ylmethyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[(5-ethyl-2H-pyrazol-3-ylamino)-methyl]cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-5-chloro-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-2-methoxy-nicotinamide; 
 trans-5-chloro-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-2-chloro-N-[4-(pyrimidin-2-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2,5-dichloro-N-{4-[(5-trifluoromethyl-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-5-chloro-2-dimethylamino-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 cis-2-chloro-N-(4-{[5-(4-fluoro-phenyl)-2H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-6-chloro-benzofuran-5-carboxylic acid {4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-amide; 
 trans-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-nicotinamide; 
 trans-2,5-dichloro-N-{4-[5-methyl-3-(2-oxo-imidazolidin-1-yl)-pyrazol-1-ylmethyl]-cyclohexyl}-benzamide; 
 cis-2-chloro-N-{4-[(4-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-2-fluoro-5-trifluoro methyl-benzamide; 
 trans-5-chloro-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-2-fluoro-benzamide; 
 trans-2-chloro-N-[4-(1-phenylamino-ethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-fluoro-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-fluoro-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3,5-difluoro-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-5-trifluoromethyl-N-{4-[(4-trifluoromethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-5-trifluoromethyl-N-{4-[(5-trifluoromethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[(2-methoxy-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-chloro-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4-methyl-pyrimidin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4,6-dimethyl-pyrimidin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2,5-dichloro-N-{4-[(5-fluoro-pyridin-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(5-fluoro-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(3,5-difluoro-pyridin-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[(6-dimethylamino-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-dimethylamino-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-6-{[4-(2-chloro-5-trifluoromethyl-benzoylamino)-cyclohexylmethyl]-amino}-nicotinic acid methyl ester; 
 trans-2-chloro-N-(4-{[5-(4-fluoro-phenyl)-1H-pyrazol-3-ylamino]-methyl}-3-methyl-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-((S)-1-phenylamino-ethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-((R)-1-phenylamino-ethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3,5-dimethyl-pyrazin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-5-chloro-2-dimethylamino-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[(5-hydroxymethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-dimethylamino-N-{4-[(4,5-dimethyl-thiazol-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-nicotinamide; 
 trans-6-{[4-(2-chloro-5-trifluoromethyl-benzoylamino)-cyclohexylmethyl]-amino}-nicotinic acid; 
 trans-5-chloro-N-{4-[(5-cyclopropyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-2-chloro-N-{4-[(5-dimethylaminomethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2,5-dichloro-N-{4-[(3,5-dimethyl-1H-pyrazol-4-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(5-cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2,5-dichloro-N-{4-[(1-propyl-1H-pyrazol-4-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-N-{4-[(6-bromo-pyridin-2-ylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-fluoro-4-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-2-methyl-N-{4-[(5-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-5-chloro-N-{4-[(4,6-dimethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-5-chloro-N-{4-[(5-fluoro-pyridin-3-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-5-chloro-2-methyl-N-{4-[(3-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-5-chloro-2-methyl-N-{4-[(1-methyl-1H-benzoimidazol-2-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-5-chloro-2-methyl-N-[4-(pyrimidin-2-ylaminomethyl)-cyclohexyl]-nicotinamide; 
 trans-5-chloro-2-dimethylamino-N-{4-[(5-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-2-methyl-N-{4-[(5-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-nicotinamide; 
 trans-2,5-dimethyl-N-{4-[(5-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-5-chloro-2-dimethylamino-N-{4-[(4,6-dimethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-N-{4-[(4,6-dimethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-2-methyl-5-trifluoro methyl-nicotinamide; 
 trans-5-chloro-2-dimethylamino-N-{4-[(5-fluoro-pyridin-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-N-{4-[(5-fluoro-pyridin-3-ylamino)-methyl]-cyclohexyl}-2-methyl-5-trifluoro methyl-nicotinamide; 
 trans-N-{4-[(5-fluoro-pyridin-3-ylamino)-methyl]-cyclohexyl}-2,5-dimethyl-nicotinamide; 
 trans-2,5-dichloro-N-{4-[(5-propyl-2H-[1,2,4]triazol-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[5-methyl-3-(2-oxo-imidazolidin-1-yl)-pyrazol-1-ylmethyl)-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[2-(4,6-dimethyl-pyridin-2-ylamino)-ethyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-fluoro-6-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2,6-dimethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 2-dimethylamino-N-{4-[(4,6-dimethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-nicotinamide; 
 trans-2-chloro-N-{4-[(5-hydroxymethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(2,4-dimethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4,6-dimethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-(4-{[5-(4-fluoro-phenyl)-1H-pyrazol-3-ylamino]-methyl}-3-methyl-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-fluoromethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4,5,6,7-tetrahydro-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-ethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1H-pyrazol-4-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-ethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-N-{4-[(5-fluoro-4-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-5-chloro-2-methyl-N-{4-[(4,5,6,7-tetrahydro-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-2-chloro-N-{4-[(2-methoxy-5-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1H-pyrazolo[3,4-b]pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-5-trifluoromethyl-N-{4-[(5-trifluoromethyl-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-benzamide; 
 trans-2-chloro-N-{4-[(5-methyl-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5,5-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(6-methyl-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-fluoro-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4-fluoro-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4,6-dimethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-isopropyl-nicotinamide; 
 trans-2-chloro-N-{4-[(4-methyl-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-chloro-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5,6-dimethoxy-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(6-methoxy-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-chloro-4-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1-methyl-1H-indazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(5-methyl-4-phenyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-N-{4-[(5-benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-ylamino)-methyl]-cyclohexyl}2-chloro-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-indazol-1-ylmethyl-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-indazol-2-ylmethyl-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-chloro-2-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(6-methyl-1H-pyrazolo[3,4-b]pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-chloro-6-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 N-{4-[(4-bromo-5-propyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoromethyl-benzamide; 
 N-[4-(3-amino-4-chloro-indazol-1-ylmethyl)-cyclohexyl]-2-chloro-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(imidazo[1,2-b]pyridazin-3-ylaminomethyl)-cyclohexyl]-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4,6-dihydro-1H-thieno[3,4-c]pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4-methyl-5-phenyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[4-(4-chloro-phenyl)-1H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 N-{4-[(7-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1-methyl-1H-pyrazolo[3,4-b]pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-N-{4-[(5-chloro-4-methyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-2-chloro-N-[4-(pyrazolo[1,5-a]pyridin-3-ylaminomethyl)-cyclohexyl]-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-(4-{[4-(2,4-dichloro-phenyl)-1H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-5-chloro-2-methyl-N-{4-[(4-trifluoromethyl-pyridin-2-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-5-chloro-2-methyl-N-{4-[(5-trifluoromethyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-2-chloro-N-{4-[(5-phenyl-4-propyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(3,5-dimethyl-[1,2,4]triazol-1-ylmethyl)-cyclohexyl]-5-trifluoro methyl-benzamide; 
 N-{4-[(6-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-methyl]-cyclohexyl}-2-chloro-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-N-{4-[(1H-indazol-3-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-2-chloro-N-[4-(3,5-dimethyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-5-chloro-2-methyl-N-{4-[(1H-pyrazolo[3,4-b]pyridin-3-ylamino)-methyl)-cyclohexyl}-nicotinamide; 
 trans-2-chloro-N-(4-{[4-(4-chloro-phenyl)-5-methyl-1H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[5-chloro-3-(4-hydroxy-cyclohexyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1H-pyrazolo[4,3-b]pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4-phenyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(6-fluoro-1H-pyrazolo[4,3-b]pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-2-methyl-N-{4-[(5-methyl-4-phenyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-2-chloro-N-{4-[(5-pyridin-3-yl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3-chloro-6-methoxy-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-chloro-6-methoxy-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1-phenyl-1H-tetrazol-5-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(1-methyl-4-phenyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(5-methyl-tetrazol-2-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(5-cyclopropyl-tetrazol-2-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(3,4-dimethyl-isoxazol-5-ylamino)-methyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[(4-pyridin-3-yl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-chloro-6-d3-methyl-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(3-phenyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-5-chloro-N-[4-(3,5-dimethyl-pyrazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide; 
 trans-2-chloro-N-(4-{[4-(4-fluoro-phenyl)-5-methyl-1H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(4-phenyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1H-pyrazolo[3,4-b]pyrazin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-2-methyl-N-{4-[(5-trifluoromethyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-2-chloro-N-[4-(4-chloro-3,5-dimethyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-[4-(3-ethoxy-5-methyl-[1,2,4]triazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(5-ethoxy-3-methyl-[1,2,4]triazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-5-trifluoromethyl-N-[4-(3,4,5-trimethyl-pyrazol-1-ylmethyl)-cyclohexyl]-benzamide; 
 trans-5-chloro-N-{4-[(5-fluoro-pyridin-2-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-2-chloro-N-{4-[(5-chloro-6-methoxy-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-2-methyl-N-{4-[(5-propyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-nicotinamide; 
 trans-2-chloro-5-trifluoromethyl-N-[4-(3-trifluoromethyl-pyrazol-1-ylmethyl)-cyclohexyl]-benzamide; 
 trans-2-chloro-N-(4-{[4-(4-chloro-phenyl)-3-methyl-isoxazol-5-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-methoxymethyl-4H-[1,2,4]triazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(trans-5-chloro-2-methoxy-pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4-chloro-5-methyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4-cyano-5-methyl-2H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[2-(4-chloro-phenyl)-5-methyl-2H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(3-methyl-5-trifluoromethyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(5-methyl-3-trifluoromethyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5-ethyl-4-methyl-1H-pyrazol-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-imidazol-1-ylmethyl-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(2-methyl-4-trifluoromethyl-imidazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(1-methyl-1H-pyrazolo[4,3-b]pyridin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-([1,2,4]triazolo[4,3-a]pyridin-3-ylaminomethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[4-(4-chloro-phenyl)-isoxazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-N-[4-(4-chloro-3,5-dimethyl-pyrazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide; 
 trans-2-chloro-N-[4-(2-methyl-imidazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-5-chloro-N-{4-[(5-chloro-2-methoxy-pyridin-3-ylamino)-methyl]-cyclohexyl}-2-methyl-nicotinamide; 
 trans-5-chloro-2-methyl-N-[4-(3,4,5-trimethyl-pyrazol-1-ylmethyl)-cyclohexyl]-nicotinamide; 
 trans-2-chloro-N-(4-{[4-(3,4-dimethoxy-phenyl)-2,5-dimethyl-2H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-(4-{[4-(2-chloro-phenyl)-1H-pyrazol-3-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(3,5-di-(d3)-methyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-[4-(5-methyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-[4-(3-methyl-pyrazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[5-(4-methoxy-phenyl)-pyrazol-1-ylmethyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-{4-[3-(4-methoxy-phenyl)-pyrazol-1-ylmethyl]-cyclohexyl}-5-trifluoro methyl-benzamide; 
 trans-2-chloro-N-(4-{[1-(4-chloro-benzyl)-1H-tetrazol-5-ylamino]-methyl}-cyclohexyl)-5-trifluoromethyl-benzamide; 
 trans-2-chloro-N-{4-[(4-chloro-5-methoxy-pyridin-2-ylamino)-methyl]-cyclohexyl}-5-trifluoromethyl-benzamide; 
 trans-5-chloro-2-methyl-N-[4-(3-methyl-5-trifluoromethyl-pyrazol-1-ylmethyl)-cyclohexyl]-nicotinamide; and 
 trans-5-chloro-2-methyl-N-[4-(5-methyl-3-trifluoromethyl-pyrazol-1-ylmethyl)-cyclohexyl]-nicotinamide; 
 and isomers thereof; 
 in free or in salt form. 
 
     
     
         9 . A method of treatment or alleviation of any state with increased endogenous level of CRF or in which the HPA (hypothalamic pituitary axis) is disregulated, or of various diseases induced or facilitated by CRF which comprises administering to a mammal a therapeutically effective amount of a compound of formula I according to  claim 1 . 
     
     
         10 . A pharmaceutical composition comprising a compound of formula I according to  claim 1  in free form or in pharmaceutically acceptable salt form, in association with a pharmaceutically acceptable adjuvant, diluent or carrier. 
     
     
         11 . A pharmaceutical composition comprising a compound of formula I according to  claim 1  in free form or in pharmaceutically acceptable salt form, in combination with another therapeutically active ingredient, optionally in association with a pharmaceutically acceptable adjuvant, diluent or carrier.