Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease

Abstract

Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.

1 - 9 . (canceled) 
     
     
         10 . A 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salt of formula 4 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents: 
       
         
           
           
               
               
           
         
       
     
     
         11 . The 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salt of  claim 10  which is 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium (2E)-3-carboxyacrylate 
       
         
           
           
               
               
           
         
       
     
     
         12 . The 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salt of  claim 10  which is 3-Carboxy-N-ethyl-N,N-dimethylpropan-1-aminium 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate 
       
         
           
           
               
               
           
         
       
     
     
         13 . The 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salt of  claim 10  which is 3-Carboxy-N-ethyl-N,N-dimethylpropan-1-aminium dihydrogen phosphate 
       
         
           
           
               
               
           
         
       
     
     
         14 . A process for preparing the 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salt according to  claim 10 , comprising:
 a. adding N,N-dimethylethylamine to ethyl 4-bromobutanoate in appropriate solvent to obtain 4-ethoxy-N-ethyl-N,N-dimethyl-4-oxo-1-butanaminium bromide;   b. passing 4-ethoxy-N-ethyl-N,N-dimethyl-4-oxo-1-butanaminium bromide through ion exchange resin column to obtain 4-[ethyl(dimethyl)ammonio] butanoate;   c. adding acid selected from the group, consisting of fumaric acid, orotic acid and phosphoric acid in appropriate solvent to obtain the corresponding 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salt.   
     
     
         15 . The process according to  claim 14 , wherein in step a) the appropriate solvent is acetonitrile or acetone. 
     
     
         16 . A method for treating cardiovascular diseases in a subject in need thereof, comprising administration of an effective amount of the 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salt of  claim 10 . 
     
     
         17 . The method according to  claim 16 , wherein the cardiovascular disease is ischemic heart disease. 
     
     
         18 . The method according to  claim 16 , wherein wherein the ischemic heart disease is myocardial infarction.