Anti-il-17f antibodies and methods of use thereof

Abstract

This invention provides fully human monoclonal antibodies that recognize IL-17F and/or the heterodimeric IL-17A/IL-17F complex, but do not recognize IL-17A. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.

What is claimed is: 
     
         1 . A method of alleviating a symptom of a clinical indication associated rheumatoid arthritis, Crohn's disease, psoriasis, multiple sclerosis chronic obstructive pulmonary disease, or asthma in a subject, the method comprising administering an antagonist of IL-17F to a subject in need thereof in an amount sufficient to alleviate the symptom of the clinical indication associated with rheumatoid arthritis, Crohn's disease, psoriasis, multiple sclerosis chronic obstructive pulmonary disease, or asthma. 
     
     
         2 . The method of  claim 1 , wherein said subject is a human. 
     
     
         3 . The method of  claim 1 , wherein said antagonist is a monoclonal antibody or fragment thereof. 
     
     
         4 . The method of  claim 3 , wherein said monoclonal antibody is an antibody according  claim 1  or fragment thereof. 
     
     
         5 . A method of alleviating a symptom of an autoimmune disease or inflammatory disorder, the method comprising administering an antibody according to  claim 1  to a subject in need thereof in an amount sufficient to alleviate the symptom of the autoimmune disease or inflammatory disorder in the subject. 
     
     
         6 . The method of  claim 5 , wherein said subject is a human. 
     
     
         7 . A method of alleviating a symptom of an arthritic condition, the method comprising administering an antibody according to  claim 1  to a subject in need thereof in an amount sufficient to alleviate the symptom of the arthritic condition in the subject. 
     
     
         8 . The method of  claim 7 , wherein said subject is a human. 
     
     
         9 . The method of  claim 7 , wherein the arthritic condition is an autoimmune arthritic condition. 
     
     
         10 . The method of  claim 7 , wherein the arthritic condition is rheumatoid arthritis.