L-sugar colon cleansing agent and uses thereof

Abstract

Disclosed is L-glucose monohydrate and compositions thereof. Also disclosed are methods for making L-glucose monohydrate and compositions thereof. Further disclosed are methods for colonic cleansing using L-sugars, such as L-glucose monohydrate, and compositions and kits useful for colonic cleansing.

1 - 28 . (canceled) 
     
     
         29 . A method for colonic cleansing comprising administering to a subject in one or more doses a composition comprising an amount of an L-sugar that is greater than about 48 g within about a 24 hour period. 
     
     
         30 . The method of  claim 29 , wherein the amount of an L-sugar is from about 48 g to about 200 g. 
     
     
         31 . The method of  claim 29 , wherein the amount of an L-sugar is from about 50 g to about 150 g. 
     
     
         32 . The method of  claim 29 , wherein the amount of an L-sugar is from about 60 g to about 140 g. 
     
     
         33 . The method of  claim 29 , wherein the amount of an L-sugar is from about 70 g to about 130 g. 
     
     
         34 . The method of  claim 29 , wherein the amount of an L-sugar is from about 80 g to about 120 g. 
     
     
         35 . The method of  claim 29 , wherein the amount of an L-sugar is from about 90 g to about 110 g. 
     
     
         36 . The method of  claim 29 , wherein the L-sugar comprises L-glucose. 
     
     
         37 . The method of  claim 29 , wherein the L-sugar comprises L-glucose monohydrate. 
     
     
         38 . The method of  claim 29 , wherein the administering comprises administering a first dose of the composition comprising the L-sugar and a second dose of the composition comprising the L-sugar within about a 24 hour period. 
     
     
         39 . The method of  claim 38 , wherein the first dose comprises at least about 36 g of the L-sugar, and the second dose comprises at least about 30 g of the L-sugar. 
     
     
         40 . The method of  claim 38 , wherein the first dose comprises from about 36 g to about 80 g of the L-sugar, and the second dose comprises from about 30 g to about g to 60 g of the L-sugar, and the second dose comprises from 40 g to 60 g of the L-sugar. 
     
     
         41 . The method of  claim 38 , wherein the first dose comprises from about 40 g to about 50 g of the L-sugar, and the second dose comprises from about 30 g to about 40 g of the L-sugar. 
     
     
         42 . The method of  claim 38 , wherein the first dose comprises from about 45 g to about 55 g of the L-sugar, and the second dose comprises from about 45 g to about 55 g of the L-sugar. 
     
     
         43 . The method of  claim 38 , wherein the first dose comprises at least about 48 g of the L-sugar, and the second dose comprises at least 48 g of the L-sugar. 
     
     
         44 . The method of  claim 38 , wherein the first dose comprises about 52.8 g L-glucose monohydrate, and the second dose comprises about 52.8 g L-glucose monohydrate. 
     
     
         45 . The method of  claim 44 , wherein the first dose is administered the night before the subject undergoes a colonoscopy, and the second dose is administered the morning of, but prior to, the colonoscopy. 
     
     
         46 . The method of  claim 44 , wherein each dose of L-glucose monohydrate is dissolved in about 8 ounces of water. 
     
     
         47 . The method of  claim 29 , wherein the administration to the subject is prior to the subject undergoing a colonoscopy. 
     
     
         48 . (canceled) 
     
     
         49 . (canceled) 
     
     
         50 . A method for colon cleansing in a subject comprising:
 (a) dissolving L-glucose monohydrate in water to form a first aqueous solution, wherein the amount of L-glucose ranges from about 36 to about 72 g (based on the weight of the base L-glucose),   (b) administering to the subject the first aqueous solution at night,   (c) dissolving L-glucose monohydrate in water to form a second aqueous solution, wherein the amount of L-glucose ranges from about 36 to about 72 g (based on the weight of the base L-glucose), and   (d) administering to the subject the second aqueous solution the following morning, wherein steps (b) and (d) are performed within about a 24 hour period.   
     
     
         51 . (canceled) 
     
     
         52 . A method for colon cleansing in a subject undergoing a colonoscopy comprising:
 (a) dissolving 52.8 g L-glucose monohydrate in about 8 fluid ounces of water to form a first aqueous solution,   (b) administering to the subject the first aqueous solution the night before the colonoscopy,   (c) dissolving 52.8 g L-glucose monohydrate in about 8 fluid ounces of water to form a second aqueous solution, and   (d) administering to the subject the second aqueous solution the morning of, but prior to, the colonoscopy,   wherein steps (b) and (d) are performed within about a 24 hour period.   
     
     
         53 . A colonic cleansing kit comprising a package and an amount of an L-sugar effective for colonic cleansing in the package, wherein the amount of L-sugar comprises a first pre-measured dose and a second pre-measured dose. 
     
     
         54 . The kit of  claim 53 , wherein the total amount of the L-sugar is greater than about 48 g. 
     
     
         55 . The kit of  claim 53 , wherein the total amount of the L-sugar is from greater than about 48 g to about 200 g. 
     
     
         56 . The kit of  claim 53 , wherein the first dose comprises at least about 36 g of the L-sugar, and the second dose comprises at least about 30 g of the L-sugar. 
     
     
         57 . The kit of  claim 53 , wherein the first dose comprises from about 36 g to about 80 g of the L-sugar, and the second dose comprises from 30 g to 80 g of the L-sugar. 
     
     
         58 . The kit of  claim 53 , wherein the L-sugar comprises L-glucose. 
     
     
         59 . The kit of  claim 53 , wherein the L-sugar comprises L-glucose monohydrate. 
     
     
         60 . The kit of  claim 59 , further comprising anhydrous L-glucose. 
     
     
         61 . The kit of  claim 48 , further comprising instructions for colonoscopy preparation.