US2014107209A1PendingUtilityA1

Formulations of low dose diclofenac and beta-cyclodextrin

58
Assignee: WRIGHT CURTISPriority: Mar 28, 2006Filed: Oct 10, 2013Published: Apr 17, 2014
Est. expiryMar 28, 2026(expired)· nominal 20-yr term from priority
Inventors:Curtis WrightDaniel B. CarrFred H. Mermelstein
A61P 29/00A61P 25/04A61K 31/195A61K 9/0019C07H 3/06A61K 47/40A61K 31/724A61K 31/196A61K 9/08A61K 9/02C08B 37/0015A61K 2300/00A61K 9/14C07H 15/04
58
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The present invention is directed to a pharmaceutical composition containing a unit dose of a diclofenac compound effective to induce analgesia; and a beta-cyclodextrin compound; wherein the dose of the diclofenac compound is less than 10 mg. The present invention is also directed to methods of treating a subject in need of analgesia with the pharmaceutical compositions of the invention.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A pharmaceutical composition comprising:
 (a) an amount of a diclofenac compound effective to induce an analgesic effect of at 1 38% on a Visual Analog Scale, wherein the amount does not exceed about 37.5 mg; and   (b) a beta-cyclodextrin compound,   wherein the pharmaceutical composition is an intravenous formulation.   
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the diclofenac compound is diclofenac sodium. 
     
     
         3 . The pharmaceutical composition of  claim 1 , wherein the cyclodextrin compound is 2-hydroxypropyl-beta-cyclodextrin. 
     
     
         4 . The pharmaceutical composition of  claim 1 , wherein the dose diclofenac compound is about 37.5 mg. 
     
     
         5 . The pharmaceutical composition of  claim 1 , wherein the dose diclofenac compound is about 18.75 mg. 
     
     
         6 . The pharmaceutical composition of  claim 1 , wherein the dose diclofenac compound is less than about 10 mg. 
     
     
         7 . The pharmaceutical composition of  claim 6 , wherein the dose diclofenac compound is about 9.4 mg. 
     
     
         8 . The pharmaceutical composition of  claim 6 , wherein the dose diclofenac compound is about 5 mg. 
     
     
         9 . The pharmaceutical composition of  claim 6 , wherein the dose diclofenac compound is about 3.75 mg. 
     
     
         10 . The pharmaceutical composition of  claim 1 , further comprising a stabilizer.

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.