US2014107505A1PendingUtilityA1
Determination of ventricular pressure and related values
Est. expiryOct 11, 2032(~6.2 yrs left)· nominal 20-yr term from priority
A61B 5/6876A61B 5/0225A61B 5/02028A61B 5/72A61B 2562/0247A61B 5/026A61B 5/7246A61B 7/045A61B 2562/0204A61B 5/02007A61B 5/7225A61B 5/4839A61B 5/022A61B 5/0215A61B 5/7278A61M 5/1723A61B 5/02125A61B 7/00
33
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Claims
Abstract
A method and a device for determining a cardiac function parameter, the device including a sonic sensor for determining timing data of a closure of a mitral valve and an aortic valve, a pressure cuff and a sensing unit coupled to the pressure cuff for sensing. The sensing unit is configured to sense, for each cardiac cycle, blood breakthrough pressure data and corresponding time data from a closing of the mitral valve and data relating to a velocity of propagation of a pressure wave as it travels along at least a portion of the pressure cuff. The device also includes a processing unit for determining a value of at least one cardiac function parameter based on the data.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A device for determining a cardiac function parameter, the device comprising:
a sonic sensor for determining timing data of a closure of a mitral valve and an aortic valve;
a pressure cuff;
a sensing unit coupled to the pressure cuff for sensing:
for each cardiac cycle, blood breakthrough pressure data and corresponding time data from a closing of the mitral valve;
data relating to a velocity of propagation of a pressure wave as it travels along at least a portion of the pressure cuff; and,
a processing unit for determining a value of at least one cardiac function parameter based on the data.
2 . The of claim 1 , wherein said at least one cardiac function parameter is selected from the group of cardiac function parameters consisting of end diastolic pressure, max dP/dT, isovolumetric contraction time, systemic vascular resistance, and central aortic pressure.
3 . The device of claim 1 , wherein the sonic sensor is a microphone.
4 . The device of claim 1 , wherein the sensing unit comprises at least two sensors.
5 . The device of claim 4 , wherein said at least two sensors are selected from the group of sensors consisting of pressure sensors and Doppler sensors.
6 . The device of claim 1 , wherein said at least one cardiac function parameter is max dP/dT, and wherein the processing unit is configured to iteratively calculate cardiac pressure and related values by calculating a slope of a tangent to a pressure waveform at a time point where the aortic valve opens.
7 . The device of claim 1 , wherein said at least one cardiac function parameter is max dP/dT, and wherein the processing unit is configured to calculate an integral of a second derivative of a polynomial function.
8 . The device of claim 1 , wherein said at least one cardiac function parameter is an end diastolic pressure, and wherein the processing unit is configured to calculate the end diastolic pressure using an equation, the equation being:
pov
=
(
1
2
×
max
P
/
T
ω
)
×
(
1
-
cos
(
ω
t
)
)
+
EDP
where:
pmax is the pressure that a isovolumetrically contracting left ventricle would produce from the end diastolic volume if ejection of blood from the ventricle would be prevented; max dP/dT is the maximum isovolumetric pressure rate in the left ventricle; ω is the angular frequency; EDP is an end diastolic pressure value; pov is the pressure at opening of an aortic valve; and, and t is the time to opening of aortic valve.
9 . The device of claim 1 , wherein said at least one cardiac function parameter is systemic vascular resistance, and wherein the processing unit is configured to determine the systemic vascular resistance by comparing a theoretical portion of an isovolumetric pressure function with an empirical central aortic pressure function.
10 . The device of claim 1 , configured to export data to a monitoring unit.
11 . A device for determining a cardiac function parameter, the device comprising:
a sonic sensor for determining timing data of a closure of a mitral valve and an aortic valve;
a pressure sensor configured to be positioned within a central aorta of a patient for sensing pressure data during a pressure build-up within the central aorta; and,
a processing unit for determining a value of at least one cardiac function parameter based on the data.
12 . The device of claim 11 , wherein the sonic sensor is a microphone.
13 . The device of claim 11 , configured to export data to a monitoring unit.
14 . The of claim 11 , wherein said at least one cardiac function parameter is selected from the group of cardiac function parameters consisting of end diastolic pressure, max dP/dT, isovolumetric contraction time, systemic vascular resistance, and central aortic pressure.
15 . The device of claim 11 , wherein said at least one cardiac function parameter is systemic vascular resistance, and wherein the processing unit is configured to determine the systemic vascular resistance by comparing a theoretical portion of an isovolumetric pressure function with an empirical central aortic pressure function.
16 . A method for determining a cardiac function parameter, the method comprising: collecting timing data of a closure of a mitral valve and an aortic valve using a sonic sensor;
using a sensing unit coupled to a pressure cuff, sensing:
for each cardiac cycle, blood breakthrough pressure data and corresponding time data from a closing of the mitral valve;
data relating to a velocity of propagation of a pressure wave as it travels along at least a portion of the pressure cuff; and,
determining a value of at least one cardiac function parameter based on the data, using a processing unit.
17 . The method of claim 16 , wherein said at least one cardiac function parameter is selected from the group of cardiac function parameters consisting of end diastolic pressure, max dP/dT, isovolumetric contraction time, systemic vascular resistance, and central aortic pressure.
18 . The method of claim 16 , wherein said at least one cardiac function parameter is max dP/dT, and wherein the processing unit is configured to iteratively calculate cardiac pressure and related values by calculating a slope of a tangent to a pressure waveform at a time point where the aortic valve opens.
19 . The method of claim 16 , wherein said at least one cardiac function parameter is an end diastolic pressure, and wherein the processing unit is configured to calculate the end diastolic pressure using an equation, the equation being:
pov
=
(
1
2
×
max
P
/
T
ω
)
×
(
1
-
cos
(
ω
t
)
)
+
EDP
where:
pmax is the pressure that a isovolumetrically contracting left ventricle would produce from the end diastolic volume if ejection of blood from the ventricle would be prevented; max dP/dT is the maximum isovolumetric pressure rate in the left ventricle; ω is the angular frequency; EDP is an end diastolic pressure value; pov is the pressure at opening of an aortic valve; and, and t is the time to opening of aortic valve.
20 . The method of claim 16 , wherein said at least one cardiac function parameter is systemic vascular resistance, and wherein the processing unit is configured to determine the systemic vascular resistance by comparing a theoretical portion of an isovolumetric pressure function with an empirical central aortic pressure function.Join the waitlist — get patent alerts
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