"Medical Articles Coated With Organopolysiloxane Containing a Protein Solution"

Abstract

This invention relates to methods for evaluating or inhibiting the aggregation of a protein in an aqueous suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution including sugar and non-ionic surfactant.

What is claimed is: 
     
         1 . A medical article, comprising:
 (a) a container comprising a chamber for receiving a solution, wherein the inner surface of the chamber has a coating thereon prepared from a composition comprising an organopolysiloxane; and   (b) a solution comprising:
 (i) at least one proteinaceous material; 
 (ii) at least one non-ionic surfactant; and 
 (iii) at least one sugar. 
   
     
     
         2 . The medical article according to  claim 1 , wherein the chamber is selected from the group consisting of a syringe barrel, drug cartridge container, needleless injector container, liquid dispensing device container, and liquid metering device container. 
     
     
         3 . The medical article according to  claim 2 , wherein the chamber is a syringe barrel. 
     
     
         4 . The medical article according to  claim 1 , wherein the chamber is formed from glass, metal, ceramic, plastic, rubber, or combinations thereof. 
     
     
         5 . The medical article according to  claim 1 , wherein the chamber is prepared from an olefinic polymer selected from the group consisting of polyethylene, polypropylene, poly(1-butene), poly(2-methyl-1-pentene), and cyclic polyolefins. 
     
     
         6 . The medical article according to  claim 1 , wherein the organopolysiloxane is polydimethylsiloxane. 
     
     
         7 . The medical article according to  claim 1 , further comprising a sealing member having an exterior surface in sliding engagement with at least a portion of the interior surface of the chamber. 
     
     
         8 . The medical article according to  claim 1 , wherein the sugar is selected from the group consisting of monosaccharides, disaccharides, trisaccharides, oligosaccharides and mixtures thereof. 
     
     
         9 . A medical article, comprising:
 (a) a container comprising a chamber for receiving a solution, wherein the inner surface of the chamber has a coating thereon prepared from a composition comprising an organopolysiloxane; and   (b) a solution comprising:
 (i) at least one proteinaceous material; and 
 (ii) at least one non-ionic surfactant.