Topical wash composition for use in acne patients

Abstract

Wash compositions for topical application are described. The compositions can be stable and well tolerated. Also described, are methods of using such compositions as cosmetic or pharmaceutical products. For example, the compositions can be used for cleansing the skin, preferably of acne patients, without compromising the skin barrier or resulting in over-compensation of sebum production. A topical wash composition is also described that can include: a) at least one surfactant; b) a zinc salt of gluconic acid; and c) a salt or derivative of glycyrrhizic acid or of glycyrrhetinic acid.

1 . A topical wash composition comprising:
 a) at least one surfactant;   b) a zinc salt of gluconic acid; and   c) a glycyrrhizic acid, a glycyrrhetinic acid or salt thereof.   
     
     
         2 . The topical wash composition according to  claim 1 , wherein:
 a) the surfactant is at least one anionic surfactant;   b) the zinc salt of gluconic acid is zinc gluconate; and   c) the glycyrrhizic acid, glycyrrhetinic acid, or salt thereof is dipotassium glycyrrhizate.   
     
     
         3 . The topical wash composition according to  claim 2 , wherein the at least one anionic surfactant is selected from the group consisting of sulfates, isethionates, olefinesulfonates, taurates and amino acids. 
     
     
         4 . The topical wash composition according to  claim 3 , wherein the at least one anionic surfactant is selected from the group consisting of zinc coceth sulfate, sodium cocoyl isethionate, sodium methyl lauroyl isethionate, sodium methyl cocoyl taurate and, C 14 -C 16  α-olefinsulfonates. 
     
     
         5 . The topical wash composition according to  claims 2 , wherein the at least one anionic surfactant is present in a concentration between 0.25% and 20% of active material (AM) relative to the total weight of the composition. 
     
     
         6 . The topical wash composition according to  claim 1 , wherein, the concentration of the zinc salt of gluconic acid, expressed by weight relative to the total weight of the composition, is between 0.1% and 1%. 
     
     
         7 . The topical wash composition according to  claim 1 , wherein, the concentration of the glycyrrhizic acid, glycyrrhetinic acid, or salt thereof, expressed by weight relative to the total weight of the composition, is between 0.1% and 1%. 
     
     
         8 . The topical wash composition according to  claim 2  comprising:
 a) between 1% and 10% of zinc coceth sulfate of active material (AM) relative to the total weight of the composition; 
 b) between 0.15% and 0.3% of zinc gluconate expressed by weight relative to the total weight of the composition; and 
 c) between 0.15% and 0.3% of dipotassium glycyrrhizate expressed by weight relative to the total weight of the composition. 
 
     
     
         9 . A composition according to  claim 1  wherein the composition is a foaming composition. 
     
     
         10 . A method of cleansing or washing the skin of an acne patient, the method comprising cleansing or washing the skin of the patient in need thereof with the topical wash composition according to  claim 1 , wherein the patient is under active treatment or in long-term maintenance. 
     
     
         11 . A method of washing acne skin, the method comprising washing the acne skin of a patient in need thereof with the topical wash composition according to  claim 1 , wherein a barrier function of the skin is kept intact. 
     
     
         12 . A method of regulating sebum production in skin of an acne patient, the method comprising regulating sebum production in the skin of the acne patient in need thereof with the topical wash composition according to  claim 1 . 
     
     
         13 . A method for improving acne skin, the method comprising administering to the acne skin of an individual subject in need thereof an effective amount of the topical wash composition according to  claim 1 . 
     
     
         14 . The topical wash composition according to  claim 4 , wherein the C 14 -C 16  α-olefinsulfonate is a sodium salt thereof. 
     
     
         15 . The topical wash composition according to  claim 5 , wherein the at least one anionic surfactant is present in a concentration of between 1% to 10% of AM. 
     
     
         16 . The topical composition according to  claim 6 , wherein the concentration of the zinc salt of glyconic acid is between 0.15% and 0.3%. 
     
     
         17 . The topical wash composition according to  claim 7 , wherein the concentration of the glycyrrhizic acid, glycyrrhetinic acid, or salt thereof is between 0.15% and 0.3%.