Benzoxazole kinase inhibitors and methods of use

Abstract

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.

1 - 55 . (canceled) 
     
     
         56 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         57 . A composition comprising the compound or pharmaceutically acceptable salt of  claim 56  and a pharmaceutically acceptable carrier. 
     
     
         58 . A method of ameliorating a disorder comprising administering to a subject in need thereof an effective amount of the compound, pharmaceutically acceptable salt or composition of  claims 56  or  57 . 
     
     
         59 . The method according to  claim 58 , wherein said disorder is selected from the group consisting of hyperproliferative disorder, bone disorder, inflammatory disease, immune disease, nervous system disease, metabolic disease, angiogenic disease, ophthalmic disease, respiratory disease, and cardiac disease. 
     
     
         60 . The method according to  claim 59 , wherein said disorder is cancer. 
     
     
         61 . The method according to  claim 60 , wherein said cancer is selected from the group consisting of fibrosarcoma, pancreatic cancer, kidney cancer, liver cancer, osteosarcoma melanoma, nasopharyngeal cancer, gastric cancer, ovarian cancer, leukemia, myeloma, breast cancer, prostate cancer, colorectal cancer, lung cancer, glioblastoma, endometrial cancer, neuroendocrine cancer, bladder cancer, mesothelioma, head and neck cancer, and cervical cancer.