US2014128616A1PendingUtilityA1
Oxygen-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
Est. expiryJan 26, 2030(~3.5 yrs left)· nominal 20-yr term from priority
Inventors:Sven RufJosef PernerstorferThorsten SadowskiGeorg HorstickHerman SchreuderChristian BuningThomas OlppBodo ScheiperKlaus Wirth
A61P 37/02A61P 37/00A61P 7/10A61P 9/12A61P 9/10A61P 9/00A61P 7/02A61P 3/10A61P 9/04A61P 7/12A61P 29/00A61P 25/04A61P 25/28A61P 25/00A61P 13/00A61P 13/12A61P 19/02A61P 11/00A61P 11/06C07D 405/12A61K 31/415C07D 231/22C07D 231/20C07D 413/12C07D 417/12C07D 401/12C07C 229/36C07D 403/12C07D 401/04
48
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Abstract
The present invention relates to compounds of the formula I, wherein A, D, E, G, R 10 , R 30 , R 40 , R 50 and R 60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Claims
exact text as granted — not AI-modified1 - 14 . (canceled)
15 . A compound 1-(2-Fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid
16 . A compound 5-Methoxy-1-phenyl-1H-pyrazole-3-carboxylic acid
17 . A compound Methyl 1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylate
18 . A compound 1-(2-Fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid
19 . A compound Ethyl (S)-3-amino-3-(2-methyl-phenyl)-propionateCited by (0)
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