Peptide yy and peptide yy agonists for treatment of metabolic disorders

Abstract

Methods and compositions are disclosed to treat metabolic disorders such as obesity, diabetes, and increased cardiovascular risk comprising administering a therapeutically effective amount of a PYY or a PYY agonist.

We claim: 
     
         1 . A method of treating obesity comprising administering to an obese subject a therapeutically effective amount of a PYY or a PYY agonist. 
     
     
         2 . The method of  claim 1  wherein the subject is at least one of insulin resistant or glucose intolerant. 
     
     
         3 . The method of  claim 1  wherein the subject has diabetes mellitus. 
     
     
         4 . The method of  claim 1  wherein the PYY agonist is PYY[3-36]. 
     
     
         5 . The method of  claim 1  wherein the PYY or PYY agonist is administered peripherally. 
     
     
         6 . The method of  claim 1  wherein about 1 μg to about 5 mg of the PYY or PYY agonist is administered per day in single or divided doses. 
     
     
         7 . The method of  claim 1  wherein about 0.01 μg/kg to about 500 μg/kg of the PYY or PYY agonist is administered per dose. 
     
     
         8 . A method of reducing food intake comprising administering to a subject a therapeutically effective amount of a PYY or a PYY agonist. 
     
     
         9 . The method of  claim 8  wherein the PYY agonist is PYY[3-36]. 
     
     
         10 . The method of  claim 8  wherein the PYY or PYY agonist is administered peripherally. 
     
     
         11 . The method of  claim 8  wherein about 1 μg to about 5 mg of the PYY or PYY agonist is administered per day in single or divided doses. 
     
     
         12 . The method of  claim 8  wherein about 0.01 μg/kg to about 500 μg/kg of the PYY or PYY agonist is administered per dose. 
     
     
         13 . A method of treating diabetes mellitus in a subject comprising administering an effective amount of a PYY or a PYY agonist. 
     
     
         14 . The method of  claim 13  wherein the PYY or PYY agonist is administered peripherally. 
     
     
         15 . The method of  claim 13  wherein the subject has Type II diabetes. 
     
     
         16 . The method of  claim 13  wherein the subject is overweight. 
     
     
         17 . The method of  claim 13  wherein the PYY agonist is PYY[3-36]. 
     
     
         18 . The method of  claim 13  wherein about 1 μg to about 5 mg of the PYY or PYY agonist is administered per day in single or divided doses. 
     
     
         19 . The method of  claim 13  wherein about 0.01 μg/kg to about 500 μg/kg of the PYY or PYY agonist is administered per dose. 
     
     
         20 . A method of improving lipid profile in a subject comprising administering to the subject an effective amount of a PYY or a PYY agonist. 
     
     
         21 . The method of  claim 20  wherein the improvement in lipid profile comprises at least one of reducing LDL cholesterol levels, reducing triglyceride levels and increasing HDL cholesterol levels. 
     
     
         22 . The method of  claim 20  wherein the PYY or PYY agonist is administered peripherally. 
     
     
         23 . A method for treating conditions or disorders which can be alleviated by reducing nutrient availability in a subject comprising administering to said subject a therapeutically effective amount of a PYY or a PYY agonist. 
     
     
         24 . The method of  claim 23  wherein the condition or disorder is hypertension. 
     
     
         25 . The method of  claim 23  wherein the condition or disorder is dyslipidemia. 
     
     
         26 . The method of  claim 23  wherein the condition is cardiovascular risk. 
     
     
         27 . The method of  claim 23  wherein the disorder is an eating disorder. 
     
     
         28 . The method of  claim 23  wherein the condition or disorder is insulin-resistance. 
     
     
         29 . The method of  claim 23  wherein the condition is obesity. 
     
     
         30 . The method of  claim 23  wherein the condition is diabetes mellitus. 
     
     
         31 . The method of  claim 23  wherein about 1 μg to about 5 mg of the PYY or PYY agonist is administered per day in single or divided doses. 
     
     
         32 . The method of  claim 23  wherein about 0.01 μg/kg to about 500 μg/kg of the PYY or PYY agonist is administered per dose. 
     
     
         33 . The method of any of  claims 1 ,  8 ,  13 ,  20 , and  23  wherein the PYY agonist has a potency in at least one of a food intake or gastric emptying assay greater than NPY.