Left atrial appendage closure implant

Abstract

A left atrial appendage closure implant may include a support frame including a first bend extending from a proximal collar to a second bend, a first segment extending from the second bend to a third bend, a second segment extending from the third bend to a fourth bend, and a third segment extending from the fourth bend to a distal collar, wherein the support frame is actuatable from a first constrained position to a second flowering position to a third mid-deployment position to a fourth unconstrained position. An implant may include a self-expanding support frame having a circumference and a central longitudinal axis, a membrane disposed over at least a portion of the support frame, and a plurality of anchors arranged into a first row and a second row such that the first row and the second row form a staggered pattern about the circumference of the support frame.

We claim: 
     
         1 . A medical device for left atrial appendage closure, comprising:
 a delivery catheter having a lumen extending therethrough; and   a left atrial appendage closure implant comprising:
 a proximal collar, a distal collar, and a monolithic support frame extending therebetween, the support frame including:
 a first bend extending from the proximal collar to a second bend; 
 a first segment extending from the second bend to a third bend; 
 a second segment extending from the third bend to a fourth bend; and 
 a third segment extending from the fourth bend to the distal collar; 
 
 wherein the support frame is actuatable from a first constrained position to a second flowering position to a third mid-deployment position to a fourth unconstrained position. 
   
     
     
         2 . The medical device of  claim 1 , wherein in the first constrained position, the left atrial appendage closure implant is disposed within the lumen of the delivery catheter with the first bend, the second bend, and the third bend substantially straightened into an elongated shape, and the fourth bend bent such that the second segment and the third segment are generally parallel to each other. 
     
     
         3 . The medical device of  claim 2 , wherein in the second flowering position, the left atrial appendage closure implant is partially disposed within the lumen of the delivery catheter such that the fourth bend is opened compared to the first constrained position, and the second segment is translated radially outward compared to the first constrained position. 
     
     
         4 . The medical device of  claim 3 , wherein in the third mid-deployment position, a proximal end of the second segment is translated radially outward and distally compared to the second flowering position. 
     
     
         5 . The medical device of  claim 4 , wherein in the third mid-deployment position, the first segment extends from the delivery catheter radially outward and distally toward the third bend, the second segment extends from the third bend radially inward and distally toward the fourth bend, and the third segment extends from the fourth bend proximally and radially inward toward the distal collar. 
     
     
         6 . The medical device of  claim 4 , wherein in the fourth unconstrained position, the left atrial appendage closure implant is disposed outside of the delivery catheter, the second bend defines a widest lateral extent of the left atrial appendage closure implant, the first segment extends from the second bend distally and radially inward toward the third bend, the second segment extends from the third bend radially inward and distally toward the fourth bend, and the third segment extends from the fourth bend proximally and radially inward toward the distal collar. 
     
     
         7 . The medical device of  claim 1 , wherein the support frame includes a plurality of anchors arranged in a first row of anchors and a second row of anchors such that the plurality of anchors forms a staggered pattern about a circumference of the left atrial appendage closure implant. 
     
     
         8 . The medical device of  claim 1 , further including a delivery shaft slidably disposed within the lumen of the delivery catheter, the delivery shaft having a distal end removably attached to the left atrial appendage closure implant at the proximal collar. 
     
     
         9 . The medical device of  claim 1 , wherein the left atrial appendage closure implant includes a membrane disposed over at least a portion of the support frame. 
     
     
         10 . A left atrial appendage closure implant, comprising:
 a self-expanding support frame having a circumference and a central longitudinal axis;   a membrane disposed over at least a portion of the support frame; and   a plurality of anchors arranged into a first row and a second row such that the first row and the second row form a staggered pattern about the circumference of the support frame.   
     
     
         11 . The left atrial appendage closure implant of  claim 10 , wherein at least some of the plurality of anchors project through the membrane. 
     
     
         12 . The left atrial appendage closure implant of  claim 10 , wherein the support frame includes a first bend adjacent a proximal collar, a second bend, a third bend, and a fourth bend adjacent a distal collar. 
     
     
         13 . The left atrial appendage closure implant of  claim 12 , wherein the support frame is actuatable between a first position, a second position, a third position, and a fourth position. 
     
     
         14 . The left atrial appendage closure implant of  claim 13 , wherein the support frame includes a plurality of struts forming a lattice of generally diamond-shaped wire portions. 
     
     
         15 . The left atrial appendage closure implant of  claim 14 , wherein the support frame includes at least a first row of generally diamond-shaped wire portions, a second row of generally diamond-shaped wire portions adjacent the first row, a third row of generally diamond-shaped wire portions adjacent the second row, and a fourth row of generally diamond-shaped wire portions adjacent the third row. 
     
     
         16 . The left atrial appendage closure implant of  claim 14 , wherein in the fourth position, at least a portion of the support frame extends distally of a distal end of the plurality of struts. 
     
     
         17 . A method of manufacturing a left atrial appendage closure implant, comprising:
 obtaining an elongate tubular member having a lumen extending therethrough and an annular ring member;   laser cutting the tubular member to form a proximal collar, a plurality of struts, a plurality of anchors interspersed among the plurality of struts, and a plurality of free distal ends;   forming the plurality of struts into a lattice of generally diamond-shaped wire portions;   fixedly attaching the plurality of free distal ends to the annular ring member;   positioning the plurality of struts such that a cross-sectional profile of the left atrial appendage closure implant in an unconstrained position includes a first bend extending radially outward from the proximal collar to a second bend, a first segment extending distally and radially inward from the second bend to a third bend, a second segment extending distally and radially inward from the third bend to a fourth bend, and a third segment extending proximally and radially inward from the fourth bend to the annular ring member; and   attaching a membrane over at least a portion of the plurality of struts such that the plurality of anchors extends through the membrane.   
     
     
         18 . The method of  claim 17 , wherein the annular ring member has an outer diameter that is smaller than an outer diameter of the elongate tubular member prior to laser cutting. 
     
     
         19 . The method of  claim 17 , wherein fixedly attaching the plurality of free ends to the annular ring member includes inserting the plurality of free distal ends into a distal end of the annular ring member.