US2014135889A9PendingUtilityA9

Implantable medical devices

46
Individually held — no corporate assignee on recordPriority: Oct 11, 2002Filed: Sep 13, 2010Published: May 15, 2014
Est. expiryOct 11, 2022(expired)· nominal 20-yr term from priority
Inventors:Ronald A. SahatjianFrancisca TanPatrick T. MatherChangdeng LiuCheryl J. Campo
A61F 2220/0016C08G 2230/00A61F 2/915A61F 2250/0039A61F 2250/0068A61L 29/14C08G 18/3893A61M 25/1027C08G 18/4833A61F 2002/8483A61F 2/91A61F 2/88C08L 65/00A61F 2002/91541A61F 2002/9528C08G 61/08A61L 31/14C08G 18/4277
46
PatentIndex Score
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Claims

Abstract

A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.

Claims

exact text as granted — not AI-modified
1 - 127 . (canceled) 
     
     
         128 . A method of delivering a prosthesis formed of a polymer into a body lumen, comprising
 delivering a collapsed polymeric prosthesis comprising polycyclooctene into a lumen in a body of a mammal, and   warming the prosthesis after delivery into the lumen to revert the collapsed polymeric prosthesis to an expanded polymeric prosthesis.   
     
     
         129 . The method of  claim 128 , wherein the prosthesis is a stent. 
     
     
         130 . The method of  claim 128 , wherein the lumen is a blood vessel. 
     
     
         131 . The method of  claim 128 , wherein the lumen is selected from the group consisting of pulmonary, esophageal, biliary, enteral, ureteral, and urethral lumens. 
     
     
         132 . The method of  claim 128 , wherein the collapsed polymeric prosthesis reverts to the expanded polymeric prosthesis at a temperature below 60° C. 
     
     
         133 . The method of  claim 128 , wherein the collapsed polymeric prosthesis reverts to the expanded polymeric prosthesis at a temperature above 37° C. 
     
     
         134 . The method of  claim 128 , wherein during the expansion the wall thickness of the polymeric prosthesis is substantially maintained. 
     
     
         135 . The method of  claim 128 , wherein only a portion of the polymeric prosthesis is in a collapsed position that reverts to an expanded position during the warming. 
     
     
         136 . The method of  claim 128 , wherein the polycyclooctene has been chemically cross-linked. 
     
     
         137 . The method of  claim 128 , wherein the polymeric prosthesis has a tubular shape. 
     
     
         138 . A method of delivering a prosthesis formed of a polymer into a body lumen, comprising
 delivering a collapsed polymeric prosthesis comprising a polymer blend including a crystalline polymer and an amorphous polymer into a lumen in a body of a mammal, and   warming the prosthesis after delivery into the lumen to revert the collapsed polymeric prosthesis to an expanded polymeric prosthesis.   
     
     
         139 . The method of  claim 138 , wherein the prosthesis is a stent. 
     
     
         140 . The method of  claim 138 , wherein the lumen is a blood vessel. 
     
     
         141 . The method of  claim 138 , wherein the lumen is selected from the group consisting of pulmonary, esophageal, biliary, enteral, ureteral, and urethral lumens. 
     
     
         142 . The method of  claim 138 , wherein the collapsed polymeric prosthesis reverts to the expanded polymeric prosthesis at a temperature below 60° C. 
     
     
         143 . The method of  claim 138 , wherein the collapsed polymeric prosthesis reverts to the expanded polymeric prosthesis at a temperature above 37° C. 
     
     
         144 . The method of  claim 138 , wherein during the expansion the wall thickness of the polymeric prosthesis is substantially maintained. 
     
     
         145 . The method of  claim 138 , wherein the polymeric prosthesis is bioabsorbable. 
     
     
         146 . The method of  claim 138 , wherein only a portion of the polymeric prosthesis is in a collapsed position that reverts to an expanded position during the warming. 
     
     
         147 . The method of  claim 138 , wherein the polymeric prosthesis has a tubular shape. 
     
     
         148 . The method of  claim 140 , wherein the amorphous polymer is selected from the group consisting of polyvinyl acetates, polymethyl acrylates, polyethyl acrylates, atactic polymethyl methacrylates, isotactic methyl methacrylates, syndiotactic polymethyl methacrylates, and other polyalkyl methacrylates. 
     
     
         149 . The method of  claim 148 , wherein the crystalline polymer is selected from the group consisting of polyvinylidene fluorides, polyglycolides, polylactides, polyhydroxyl butyrates, polyethylene glycols, polyethylenes, polyethylene-co-vinyl acetates, polyvinyl chlorides, polyvinylidene chlorides and copolymers of polyvinylidene chloride/polyvinyl chloride. 
     
     
         150 . The method of  claim 138  wherein the crystalline polymer is selected from the group consisting of polyvinylidene fluorides, polyglycolides, polylactides, polyhydroxyl butyrates, polyethylene glycols, polyethylenes, polyethylene-co-vinyl acetates, polyvinyl chlorides, polyvinylidene chlorides and copolymers of polyvinylidene chloride/polyvinyl chloride. 
     
     
         151 . The method of  claim 149 , wherein said blend comprises polyvinyl acetate and polylactide. 
     
     
         152 . The method of  claim 149 , wherein said blend comprises polyvinyl acetate and polyvinylidene fluoride. 
     
     
         153 . The method of  claim 149 , wherein said blend comprises polyvinylidene fluoride and polymethyl methacrylate. 
     
     
         154 . The method of  claim 149 , wherein said blend comprises polyvinylidene chloride and polyvinyl acetate. 
     
     
         155 . A method of delivering a prosthesis formed of a polymer into a body lumen, comprising
 delivering a collapsed polymeric prosthesis comprising a polymeric material including a reaction product of polyol, isocyanate, and a polyhedral oligosilsesquioxane diol into a lumen in a body of a mammal, and   warming the prosthesis after delivery into the lumen to revert the collapsed polymeric prosthesis to an expanded polymeric prosthesis.   
     
     
         156 . The method of  claim 155 , wherein the prosthesis is a stent. 
     
     
         157 . The method of  claim 155 , wherein the lumen is a blood vessel. 
     
     
         158 . The method of  claim 155 , wherein the lumen is selected from the group consisting of pulmonary, esophageal, biliary, enteral, ureteral, and urethral lumens. 
     
     
         159 . The method of  claim 155 , wherein the collapsed polymeric prosthesis reverts to the expanded polymeric prosthesis at a temperature below 60° C. 
     
     
         160 . The method of  claim 155 , wherein the collapsed polymeric prosthesis reverts to the expanded polymeric prosthesis at a temperature above 37° C. 
     
     
         161 . The method of  claim 155 , wherein during the expansion the wall thickness of the polymeric prosthesis is substantially maintained. 
     
     
         162 . The method of  claim 155 , wherein the polymeric prosthesis is bioabsorbable. 
     
     
         163 . The method of  claim 155 , wherein only a portion of the collapsed polymeric prosthesis is in a collapsed position that reverts to an expanded position during the warming. 
     
     
         164 . The method of  claim 155 , wherein the polymeric prosthesis has a tubular shape. 
     
     
         165 . The method of  claim 155 , wherein the polyol is selected from the group consisting of be polyethylene glycol, polycaprolactone polyol, polycyclooctene polyol, trans-1,4 butadiene polyol, transisoprene polyol, polynorbornene polyol, polymethacrylate copolymer polyol, polycaprolactone-polylactide copolymer polyol, polycaprolactone-polyglycolide copolymer polyol, polycaprolactone-polylactide-polyglycolide copolymer polyol, polylactide polyol and mixtures thereof. 
     
     
         166 . The method of  claim 155 , wherein the isocyanate is selected from the group consisting of 4,4′-diphenyl methylene diisocyanate, toluene-2,4-diisocyanate, toluene-2,6-diisocyanate, hexamethylene-1,6-diisocyanate, isophorone diisocyanate, and hydrogenated 4,4′-diphenylmethylene diisocyanate, and mixtures thereof. 
     
     
         167 . The method of  claim 155 , wherein the polyhedral oligosilsesquioxane diol is a member selected from the group consisting of 2-ethyl-2-[3-[[(heptacyclopentylpentacyclo-[9.5.1.1 3,9 .1 5,15 .1 7,13 ]octasiloxanyl)oxy[dimethylsilyl]-propoxy]methyl]-1,3-propanediol, 2-ethyl-2-[3-[[(heptacyclohexylpentacyclo-]9.5.1.1 3,9 .1 5,15 .1 7,13 ]octasiloxanyl)oxy[dimethylsilyl]-propoxy]methyl]-1,3-propanediol, 2-ethyl-2-[3-[[(heptaisobutylpentacyclo-[9.5.1.1 3.9 .1 7,13 ]octasiloxanyl)oxy]dimethylsilyl]-propoxy]methyl]-1,3-prop anediol, 1-(2-trans-cyclohexanediol)ethyl-3,5,7,9,11,13,15-cyclohexanepentacyclo-[-9.5.1.1 3,9 .1 5,15 .1 7,13 ]octasiloxane, and 1-(2-trans-cyclohexanediol)ethyl-3,5,7,9,11,13,15-isobutylpentacyclo-[9.5.1.1 3,9 .1 5,15 . 7,13 ]octasiloxane. 
     
     
         168 . The method of  claim 155 , wherein
 (a) the polyol is selected from the group consisting of be polyethylene glycol, polycaprolactone polyol, polycyclooctene polyol, trans-1,4 butadiene polyol, transisoprene polyol, polynorbornene polyol, polymethacrylate copolymer polyol, polycaprolactone-polylactide copolymer polyol, polycaprolactone-polyglycolide copolymer polyol, polycaprolactone-polylactide-polyglycolide copolymer polyol, polylactide polyol and mixtures thereof,   (b) the isocyanate is selected from the group consisting of 4,4′-diphenyl methylene diisocyanate, toluene-2,4-diisocyanate, toluene-2,6-diisocyanate, hexamethylene-1,6-diisocyanate, isophorone diisocyanate, and hydrogenated 4,4′-diphenylmethylene diisocyanate, and mixtures thereof, and   (c) wherein the polyhedral oligosilsesquioxane diol is a member selected from the group consisting of 2-ethyl-2-[3-[[(heptacyclopentylpentacyclo-[9.5.1.1 3,9 .1 5,15 .1 7,13 ]octasiloxanyl)oxy[dimethylsilyl]-propoxy]methyl]-1,3-propanediol, 2-ethyl-2-[ 3 -[[(heptacyclohexylpentacyclo-]9.5.1.1 3,9 .1 5,15 .1 7,13 ]octasiloxanyl)oxy[dimethylsilyl]-propoxy]methyl]-1,3-propanediol, 2-ethyl-2-[ 3 -[[(heptaisobutylpentacyclo-[9.5.1.1 3,9 .1 7,13 ]octasiloxanyl)oxy]dimethylsilyl]-propoxy]methyl]-1,3-propanediol, 1-(2-trans-cyclohexanediol)ethyl-3,5,7,9,11,13,15-cyclohexanepentacyclo-[-9.5.1.1 3,9 .1 5,15 .1 7,13 ]octasiloxane, and 1-(2-trans-cyclohexanediol)ethyl-3,5,7,9,11,13,15-isobutylpentacyclo-[9.5.1.1 3,9 .1 5,15 .1 7,13 ]octasiloxane.   
     
     
         169 . The method of  claim 155 , wherein the reaction product is bioabsorbable and has the formula 
       
         
           
           
               
               
           
         
       
       where X and Y are 1 to 20, n is 2 to 1000, and m is 2 to 100.

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