Vaccine to protect a ruminant against pneumonia caused by pasteurella multocida

Abstract

The present invention pertains to a vaccine comprising live attenuated Pasteurella multocida bacteria for protection of a ruminant against pneumonia caused by Pasteurella multocida by administration of the vaccine to the upper respiratory tract of the ruminant via atomisation of the vaccine. The invention also pertains to a method to use the vaccine to protect a ruminant against pneumonia caused by Pasteurella multocida bacteria.

1 . A vaccine comprising live attenuated  Pasteurella multocida  bacteria for protection of a ruminant against pneumonia caused by  Pasteurella multocida  by administration of the vaccine to the upper respiratory tract of the ruminant via atomisation of the vaccine. 
     
     
         2 . The vaccine of  claim 1 , wherein the administration takes place via intranasal atomisation. 
     
     
         3 . The vaccine of  claim 1 , wherein the atomisation provides a mist of vaccine particles having an average size below 50 μm in diameter. 
     
     
         4 . The vaccine of  claim 3 , wherein the average particle size is between 20 and 40 μm in diameter. 
     
     
         5 . The vaccine of  claim 1 , wherein the vaccine additionally comprises live attenuated parainfluenza-3 virus and live attenuated bovine respiratory syncytial virus for protection against respiratory disease caused by parainfluenza virus and bovine respiratory syncytial virus. 
     
     
         6 . The vaccine of  claim 5 , wherein it comprises live attenuated infectious bovine rhinotracheitis virus for protection against respiratory disease caused by infectious bovine rhinotracheitis virus. 
     
     
         7 . A method to protect a ruminant against pneumonia caused by  Pasteurella multocida  bacteria, the method comprising administration of a vaccine comprising live attenuated  Pasteurella multocida  bacteria, to the upper respiratory tract of the ruminant by atomisation of the vaccine.