Treatment of Cognitive Disorders with (R)-7-Chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-Carboxamide and Pharmaceutically Acceptable Salts Thereof

Abstract

(R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide has been found to have procognitive effects in humans at unexpectedly low doses. Thus, (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof can be used at unexpectedly low doses to improve cognition.

1 . A method for improving cognition comprising administering to a subject (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide or a pharmaceutically acceptable salt thereof at a daily dose of less than 3 mg. 
     
     
         2 . The method of  claim 1  wherein the daily dose is 1 mg or less. 
     
     
         3 . The method of  claim 2  wherein the daily dose is 0.3 mg or less. 
     
     
         4 . (canceled) 
     
     
         5 . The method of  claim 1  wherein the daily dose is 1 mg or less. 
     
     
         6 . The method of  claim 5  wherein the daily dose is 0.3 mg or less. 
     
     
         7 . (canceled) 
     
     
         8 . The method of  claim 1  wherein the daily dose is 1 mg or less. 
     
     
         9 . The method of  claim 8  wherein the daily dose is 0.3 mg or less 
     
     
         10 . (canceled) 
     
     
         11 . The method of  claim 1  wherein the daily dose is 1 mg or less. 
     
     
         12 . The method of  claim 11  wherein the daily dose is 0.3 mg or less. 
     
     
         13 . (canceled) 
     
     
         14 . The method of  claim 1  wherein the daily dose is 1 mg or less. 
     
     
         15 . The method of  claim 14  wherein the daily dose is 0.3 mg or less. 
     
     
         16 . (canceled) 
     
     
         17 . The method of  claim 1  wherein the daily dose is 1 mg or less. 
     
     
         18 . The method of  claim 17  wherein the daily dose is 0.3 mg or less. 
     
     
         19 . (canceled) 
     
     
         20 . The method of  claim 1  wherein the daily dose is 1 mg or less. 
     
     
         21 . The method of  claim 20  wherein the daily dose is 0.3 mg or less. 
     
     
         22 . (canceled) 
     
     
         23 . The method of  claim 1  wherein the daily dose is 1 mg or less. 
     
     
         24 . The method of  claim 11  wherein the daily dose is 0.3 mg or less. 
     
     
         25 . The method of  claim 1 , wherein the subject is suffering from anxiety or agitation. 
     
     
         26 - 28 . (canceled)