Formulas comprising highly soluble elements and vitamin for the prevention and amelioration of osteoporosis

Abstract

The present invention provides methods of producing dosage forms for formulas of elemental compositions encompassing acetate salts of calcium, magnesium and zinc along with vitamin D 3 . The acetate salts could be extracted from natural sources such as pearls, coral, and oyster or compounded using synthetic materials. The dosage and ratio of calcium to magnesium was estimated using in vitro and in vivo estimations. The dosage for promoting bone health and alleviation of osteoporosis is about a quarter to a third of the conventional dose.

What is claimed is: 
     
         1 . A method of preparing tablets comprising calcium acetate, magnesium acetate, zinc acetate and vitamin D 3 , the method comprises the steps of:
 (i) blending a first calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate with a composition comprising vitamin D 3 ; and   (ii) blending the composition obtained from (i) with a second calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate;   (iii) performing one or more rounds of blending wherein in each blending a composition obtained from a previous step is blended with yet another calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate, thereby obtaining composition comprising calcium acetate, magnesium acetate, zinc acetate and vitamin D 3  for preparing tablets.   
     
     
         2 . A tablet produced by the method of  claim 1 . 
     
     
         3 . A method of preparing soft gel capsules comprising calcium acetate, magnesium acetate, zinc acetate, oil and vitamin D 3 , the method comprises the steps of:
 (i) dissolving vitamin D 3  in oil comprising omega 3 or omega 3-6-9; and   (ii) blending the composition obtained from (i) with a calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate, thereby obtaining composition comprising calcium acetate, magnesium acetate, zinc acetate, oil and vitamin D 3  for preparing soft gel capsules.   
     
     
         4 . The method of  claim 1  or  3 , wherein the calcium composition comprises at least 10 percent by weight of calcium acetate, at least 5 percent by weight of magnesium acetate, and at least 0.2 percent by weight of zinc acetate. 
     
     
         5 . The method of  claim 3 , wherein the oil is fish oil or flaxseed oil. 
     
     
         6 . The method of  claim 3 , wherein the oil to calcium acetate blend ratio is selected from the group consisting of 1:1, 1.5:1 and 2:1. 
     
     
         7 . The method of  claim 3 , wherein the oil to calcium ratio is selected from the group consisting of 1:0.14, 1.5:1 and 2:1. 
     
     
         8 . The method of  claim 3 , wherein the oil to magnesium ratio is selected from the group consisting of 1:0.07, 1.5:0.07 and 2:0.07. 
     
     
         9 . The method of  claim 3 , wherein the oil to zinc ratio is selected from the group consisting of 1:0.007, 1.5:0.007 and 2:0.007. 
     
     
         10 . A soft gel capsule produced using the method of  claim 3 .